In Vitro Release Kinetics and Transferrin Saturation Study of Intravenous Iron Sucrose Entrapped in Poly(ethylene glycol)-Assisted Silica Xerogel

2015 ◽  
Vol 178 (7) ◽  
pp. 1351-1362 ◽  
Author(s):  
Jahnavi Jha ◽  
Suparna Chakraborty ◽  
Mahua Ghosh Chaudhuri ◽  
Rajib Dey
Keyword(s):  
Ethylene Glycol ◽  
Release Kinetics ◽  
Transferrin Saturation ◽  
In Vitro Release ◽  
Intravenous Iron ◽  
Silica Xerogel ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Vitro Release

In vitro release of plasmid DNA from oligo(poly(ethylene glycol) fumarate) hydrogels

2005 ◽  
Vol 104 (3) ◽  
pp. 521-539 ◽  
Author(s):  
F. Kurtis Kasper ◽  
Stephanie K. Seidlits ◽  
Andrew Tang ◽  
Roger S. Crowther ◽  
Darrell H. Carney ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Plasmid Dna ◽  
In Vitro Release ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Vitro Release

Methoxy-Poly(ethylene glycol)-block-Poly(ε-caprolactone) Bearing Pendant Aldehyde Groups as pH-Responsive Drug Delivery Carrier

2013 ◽  
Vol 66 (12) ◽  
pp. 1576 ◽  
Author(s):  
Gejun Ma ◽  
Deshan Li ◽  
Ji Wang ◽  
Xuefei Zhang ◽  
Haoyu Tang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
In Vitro Release ◽  
Amphiphilic Block Copolymer ◽  
Poly Ethylene Glycol ◽  
Ph Change ◽  
Poly Ethylene ◽  
Aldehyde Groups

A biodegradable amphiphilic block copolymer of methoxy poly(ethylene glycol)-block-poly(ϵ-caprolactone) bearing pendant aldehyde groups was synthesised by a combination of ring-opening polymerisation and thio-bromo ‘click’ chemistry. The free aldehyde groups on the copolymer were reacted with hydrophobic payloads (p-methoxylaniline as a model drug) by a benzoic–imine linker, which was responsive to pH change. NMR, FTIR, and gel permeation chromatography analysis confirmed the copolymer structures. In vitro release studies revealed that under acid stimulus, hydrolysis of the benzoic–imine bond resulted in a rapid drug release. This new amphiphilic block copolymer is expected to have promising applications in biodegradable controlled drug delivery systems.

scholarly journals Microfluidic encapsulation of SN-38 in block copolymer nanoparticles: effect of hydrophobic block composition on loading and release properties

2019 ◽  
Vol 97 (5) ◽  
pp. 337-343
Author(s):  
Danica Jensen ◽  
Yimeng Cao ◽  
Changhai Lu ◽  
Jeremy E. Wulff ◽  
Matthew G. Moffitt
Keyword(s):  
Release Kinetics ◽  
In Vitro Release ◽  
Polymer Nanoparticles ◽  
Amphiphilic Block Copolymers ◽  
Poly Ethylene Oxide ◽  
Rigid Rod ◽  
Poly Ethylene ◽  
20 Nm ◽  
Vitro Release

A gas–liquid microfluidic reactor was used to prepare polymer nanoparticles (PNPs) containing the drug 7-ethyl-10-hydroxy camptothecin (SN-38) from a series of poly(methyl caprolactone-co-caprolactone)-b-poly(ethylene oxide) (P(MCL-co-CL)-b-PEO) amphiphilic block copolymers with variable MCL content in the hydrophobic block. All three copolymers formed spheres with ∼20 nm core diameters by TEM, although some rigid rod-like aggregates were also formed by the PMCL-50 and PMCL-75 copolymers. SN-38 encapsulation efficiencies (EE = 2.7%–3.0%) and loading levels (DL = 2.0%–2.9%) were similar for the three copolymers. In vitro release kinetics became significantly slower as the MCL content increased, with release half times increasing monotonically from 3.4 to 6.2 h as the MCL content of the hydrophobic block increased from 50% to 100%. The ability to systematically tune release half times via controlled variation in the hydrophobic block composition, while maintaining constant PNP size and loading levels, represents an intriguing chemical handle for the optimization of SN-38 nanomedicines.

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