Dietary Selenium Deficiency Facilitated Reduced Stomatin and Phosphatidylserine Externalization, Increasing Erythrocyte Osmotic Fragility in Mice

2020 ◽  
Vol 199 (2) ◽  
pp. 594-603 ◽  
Author(s):  
Shi-yu Duan ◽  
Si-jie Chen ◽  
Wan Liang ◽  
Miao-yu Chen ◽  
Yu Chen ◽  
...  
Keyword(s):  
Osmotic Fragility ◽  
Selenium Deficiency ◽  
Dietary Selenium ◽  
Phosphatidylserine Externalization ◽  
Erythrocyte Osmotic Fragility

scholarly journals Minor Changes in Erythrocyte Osmotic Fragility in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice

2021 ◽  
Vol 22 (14) ◽  
pp. 7307
Author(s):  
Ilya S. Zhukov ◽  
Larisa G. Kubarskaya ◽  
Inessa V. Karpova ◽  
Anastasia N. Vaganova ◽  
Marina N. Karpenko ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Emotional Regulation ◽  
Complete Blood Count ◽  
Gene Knockout ◽  
Hematological Parameters ◽  
Osmotic Fragility ◽  
Erythrocyte Osmotic Fragility ◽  
Trace Amine ◽  
Socially Relevant ◽  
The Impact

Trace amine-associated receptors (TAARs) are a group of G protein-coupled receptors that are expressed in the olfactory epithelium, central nervous system, and periphery. TAAR family generally consists of nine types of receptors (TAAR1-9), which can detect biogenic amines. During the last 5 years, the TAAR5 receptor became one of the most intriguing receptors in this subfamily. Recent studies revealed that TAAR5 is involved not only in sensing socially relevant odors but also in the regulation of dopamine and serotonin transmission, emotional regulation, and adult neurogenesis by providing significant input from the olfactory system to the limbic brain areas. Such results indicate that future antagonistic TAAR5-based therapies may have high pharmacological potential in the field of neuropsychiatric disorders. TAAR5 is known to be expressed in leucocytes as well. To evaluate potential hematological side effects of such future treatments we analyzed several hematological parameters in mice lacking TAAR5. In these mutants, we observed minor but significant changes in the osmotic fragility test of erythrocytes and hematocrit levels. At the same time, analysis of other parameters including complete blood count and reticulocyte levels showed no significant alterations in TAAR5 knockout mice. Thus, TAAR5 gene knockout leads to minor negative changes in the erythropoiesis or eryptosis processes, and further research in that field is needed. The impact of TAAR5 deficiency on other hematological parameters seems minimal. Such negative, albeit minor, effects of TAAR5 deficiency should be taken into account during future TAAR5-based therapy development.

scholarly journals Dietary Selenium Deficiency Exacerbates DSS-Induced Epithelial Injury and AOM/DSS-Induced Tumorigenesis

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67845 ◽  
Author(s):  
Caitlyn W. Barrett ◽  
Kshipra Singh ◽  
Amy K. Motley ◽  
Mary K. Lintel ◽  
Elena Matafonova ◽  
...  
Keyword(s):  
Selenium Deficiency ◽  
Epithelial Injury ◽  
Dietary Selenium

Effects of melatonin on cloacal temperature and erythrocyte osmotic fragility in layer hens during the hot-dry season

2014 ◽  
Vol 43 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Victor Olusegun Sinkalu ◽  
Joseph Olusegun Ayo ◽  
Ariyo Adelaja Abimbola ◽  
Josiah Egbamushe Ibrahim
Keyword(s):  
Osmotic Fragility ◽  
Dry Season ◽  
Erythrocyte Osmotic Fragility ◽  
Hot Dry Season ◽  
Layer Hens

Erythrocyte osmotic fragility in response to a short road transport in cattle, horses, and goats

2016 ◽  
Vol 12 ◽  
pp. 82-84 ◽  
Author(s):  
Francesco Fazio ◽  
Stefania Casella ◽  
Claudia Giannetto ◽  
Elisabetta Giudice ◽  
Giuseppe Piccione
Keyword(s):  
Osmotic Fragility ◽  
Road Transport ◽  
Erythrocyte Osmotic Fragility

scholarly journals Seasonal Variation in the Haematological Parameters of the Adult Mallard Duck in a Tropical Environment

2020 ◽  
pp. 30-37
Author(s):  
O. S. Olawuwo ◽  
O. I. Azeez ◽  
J. O. Oyewale
Keyword(s):  
Seasonal Variation ◽  
Osmotic Fragility ◽  
Dry Season ◽  
Tropical Environment ◽  
Haematological Parameters ◽  
Mallard Duck ◽  
Corpuscular Haemoglobin ◽  
Erythrocyte Osmotic Fragility ◽  
Mean Corpuscular Haemoglobin ◽  
Erythrocyte Fragility

Duck production is a growing poultry enterprise in Nigeria and they are mostly reared in extensive management system. However, the haematological profiles as influenced by the tropical environment have not been well documented. The objective of the present study was to examine the seasonal variation in the haematological parameters of the adult Mallard duck in the tropical environment of Nigeria; as they effects duck production adversely. The Erythrocyte, leucocyte and platelet counts, as well as the erythrocyte osmotic fragility of the domestic duck of the mallard breed during the wet and dry seasons in the hot humid tropical environment of the Experimental Animal Unit of the Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria was investigated. The study showed that the values of the packed cell volume (PCV), mean corpuscular haemoglobin (MCH) and platelet were significantly higher in the dry season than in the wet season, but the red blood cell (RBC), haemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), total and differential leucocyte values were similar in the two seasons. The erythrocyte fragility was also higher in the dry season. In conclusion the higher PCV, MCH and platelet values in the dry season might have resulted from haemoconcentration occasioned by higher evaporative heat loss, which is a common occurrence in the dry season. The higher erythrocyte fragility could have been the result of stress induced by the high ambient temperature during the dry season, or higher metabolic rate associated with lactic acid accumulation, which has been shown to increase erythrocyte osmotic fragility.

Erythrocyte osmotic fragility and lipid peroxidation in experimental hyperthyroidism

Endocrine ◽  
2009 ◽  
Vol 36 (3) ◽  
pp. 498-502 ◽  
Author(s):  
Rıfat Yücel ◽  
Semra Özdemir ◽  
Nuran Darıyerli ◽  
Selmin Toplan ◽  
M. Can Akyolcu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Osmotic Fragility ◽  
Experimental Hyperthyroidism ◽  
Erythrocyte Osmotic Fragility
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