Differential Expression of Hippocampal Circular RNAs in the BTBR Mouse Model for Autism Spectrum Disorder

2020 ◽  
Vol 57 (5) ◽  
pp. 2301-2313 ◽  
Author(s):  
Silvia Gasparini ◽  
Giorgia Del Vecchio ◽  
Silvia Gioiosa ◽  
Tiziano Flati ◽  
Tiziana Castrignano ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Differential Expression ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Circular Rnas ◽  
Btbr Mouse

scholarly journals Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Lorena Coretti ◽  
Claudia Cristiano ◽  
Ermanno Florio ◽  
Giovanni Scala ◽  
Adriano Lama ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Microbiota Composition ◽  
Btbr Mouse ◽  
Gut Microbiota Composition

scholarly journals The effects of aging on the BTBR mouse model of autism spectrum disorder

2014 ◽  
Vol 6 ◽  
Author(s):  
Joan M. Jasien ◽  
Caitlin M. Daimon ◽  
Rui Wang ◽  
Bruce K. Shapiro ◽  
Bronwen Martin ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Btbr Mouse ◽  
Effects Of Aging

scholarly journals Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder

2015 ◽  
Vol 6 ◽  
Author(s):  
Caitlin M. Daimon ◽  
Joan M. Jasien ◽  
William H. Wood ◽  
Yongqing Zhang ◽  
Kevin G. Becker ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Btbr Mouse

scholarly journals Serotonin 6 receptor blockade reduces repetitive behavior in the BTBR mouse model of autism spectrum disorder

2021 ◽  
Vol 200 ◽  
pp. 173076
Author(s):  
Dionisio A. Amodeo ◽  
Brandon Oliver ◽  
Alma Pahua ◽  
Kristianna Hitchcock ◽  
Alexa Bykowski ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Receptor Blockade ◽  
Btbr Mouse

Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder

2016 ◽  
Vol 41 (11) ◽  
pp. 3129-3137 ◽  
Author(s):  
Hongen Wei ◽  
Yuehong Ma ◽  
Caiyun Ding ◽  
Guorong Jin ◽  
Jianrong Liu ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Glutamate Release ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Btbr Mouse

Epothilone D Modulates Autism-Like Behaviors in the BTBR Mouse Model of Autism Spectrum Disorder

2021 ◽  
Author(s):  
Min Zhao ◽  
Qiaoqiao Chang ◽  
Hua Yang ◽  
Min Wang ◽  
Yongfeng Liu ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Btbr Mouse ◽  
Epothilone D

scholarly journals Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Kohei Kitagawa ◽  
Kensuke Matsumura ◽  
Masayuki Baba ◽  
Momoka Kondo ◽  
Tomoya Takemoto ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Social Behavior ◽  
Mouse Model ◽  
Mouse Models ◽  
De Novo ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
De Novo Mutation ◽  
Behavioral Deficits

AbstractAutism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by core symptoms of impaired social behavior and communication. Recent studies have suggested that the oxytocin system, which regulates social behavior in mammals, is potentially involved in ASD. Mouse models of ASD provide a useful system for understanding the associations between an impaired oxytocin system and social behavior deficits. However, limited studies have shown the involvement of the oxytocin system in the behavioral phenotypes in mouse models of ASD. We have previously demonstrated that a mouse model that carries the ASD patient-derived de novo mutation in the pogo transposable element derived with zinc finger domain (POGZWT/Q1038R mice), showed ASD-like social behavioral deficits. Here, we have explored whether oxytocin (OXT) administration improves impaired social behavior in POGZWT/Q1038R mice and found that intranasal oxytocin administration effectively restored the impaired social behavior in POGZWT/Q1038R mice. We also found that the expression level of the oxytocin receptor gene (OXTR) was low in POGZWT/Q1038R mice. However, we did not detect significant changes in the number of OXT-expressing neurons between the paraventricular nucleus of POGZWT/Q1038R mice and that of WT mice. A chromatin immunoprecipitation assay revealed that POGZ binds to the promoter region of OXTR and is involved in the transcriptional regulation of OXTR. In summary, our study demonstrate that the pathogenic mutation in the POGZ, a high-confidence ASD gene, impairs the oxytocin system and social behavior in mice, providing insights into the development of oxytocin-based therapeutics for ASD.

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