Role of Liver Growth Factor (LGF) in Parkinson’s Disease: Molecular Insights and Therapeutic Opportunities

2021 ◽  
Author(s):  
Efthalia Angelopoulou ◽  
Yam Nath Paudel ◽  
Christina Piperi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Liver Growth

scholarly journals Intrastriatal Infusion of Liver Growth Factor Stimulates Dopamine Terminal Sprouting and Partially Restores Motor Function in 6-Hydroxydopamine-lesioned Rats

2006 ◽  
Vol 54 (4) ◽  
pp. 457-465 ◽  
Author(s):  
Diana Reimers ◽  
Antonio S. Herranz ◽  
Juan José Diaz-Gil ◽  
Ma Val T. Lobo ◽  
Carlos L. Paíno ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Biological Activity ◽  
Growth Factor ◽  
Tyrosine Hydroxylase ◽  
Liver Growth ◽  
Microglial Proliferation ◽  
The Times ◽  
6 Hydroxydopamine ◽  
Experimental Group

Liver growth factor (LGF) is a mitogen for liver cells that shows biological activity in extrahepatic sites and may be useful for neuroregenerative therapies. The aim of this work was to investigate the effects of the intrastriatal (IS) infusion of LGF in the 6-hydroxydopamine rat model of Parkinson's disease. Tyrosine hydroxylase-positive innervation was significantly increased in the dopamine-denervated striatum of rats receiving intrastriatal LGF infusions (160 ng/day/rat × 15 days) as compared with a vehicle-infused group. There was no evidence of dopaminergic neurogenesis in the striatum or substantia nigra in any experimental group at the times studied. However, in those animals undergoing IS-LGF infusion for 48 hr, we found a significant increase in both microglial proliferation and in the number of microglial cells that acquired the ameboid morphology. This is characteristic of activated microglia/macrophages that has been reported to play an important role in dopamine terminal sprouting. In summary, our study shows that IS infusion of LGF stimulates the outgrowth of tyrosine hydroxylase-positive terminals in the striatum of 6-hydroxydopamine-treated rats. As apomorphine-induced rotational behavior was also reduced in these animals, we propose LGF as a novel factor that, when delivered to the striatum, may be useful in the treatment of Parkinson's disease.

Liver Growth Factor Promotes the Survival of Grafted Neural Stem Cells in a Rat Model of Parkinson's Disease

2012 ◽  
Vol 7 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Diana Reimers ◽  
Cristina Osuna ◽  
Rafael Gonzalo-Gobernado ◽  
Antonio S. Herranz ◽  
Juan Jose Diaz-Gil ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Rat Model ◽  
Liver Growth

scholarly journals Neuroprotective Activity of Peripherally Administered Liver Growth Factor in a Rat Model of Parkinson’s Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67771 ◽  
Author(s):  
Rafael Gonzalo-Gobernado ◽  
Lucía Calatrava-Ferreras ◽  
Diana Reimers ◽  
Antonio Sánchez Herranz ◽  
Macarena Rodríguez-Serrano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Rat Model ◽  
Neuroprotective Activity ◽  
Liver Growth
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