CircRNA circ_0067772 aggravates the malignant progression of cutaneous squamous cell carcinoma by regulating miR-1238-3p/FOXG1 axis

2021 ◽  
Author(s):  
Xiaoqing Li ◽  
Yinghui Kong ◽  
He Li ◽  
Manyuan Xu ◽  
Ming Jiang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Malignant Progression

scholarly journals Targeting 14-3-3ε activates apoptotic signaling to prevent cutaneous squamous cell carcinoma

2020 ◽  
Author(s):  
Thomas R Holmes ◽  
Jenan Al Matouq ◽  
Matti Holmes ◽  
Natasha Sioda ◽  
Justin C Rudd ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Development ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Malignant Progression ◽  
Skin Tumor ◽  
Premalignant Lesions

Abstract More than a million cases of cutaneous squamous cell carcinoma are diagnosed in the USA each year, and its incidence is increasing. Most of these malignancies arise from premalignant lesions, providing an opportunity for intervention before malignant progression. We previously documented how cytoplasmic mislocalization of CDC25A in premalignant and malignant skin cancers confers resistance to apoptotic cell death via a mechanism that depends on its interaction with 14-3-3ε. From these data, we hypothesized that 14-3-3ε overexpression drives skin tumor development and progression, such that targeting 14-3-3ε may be a useful strategy for skin cancer treatment. Like CDC25A, 14-3-3ε was overexpressed and mislocalized to the cytoplasm of both benign and malignant human skin cancer. Skin-targeted deletion of the 14-3-3ε gene reduced skin tumor development by 75% and blocked malignant progression. 14-3-3ε suppressed apoptosis through activation of Akt, leading to inhibition of BCL2 associated agonist of cell death and upregulation of Survivin. Using virtual tetrapeptide libraries, we developed a novel peptide that specifically blocked 14-3-3ε heterodimerization and thereby prevented its interaction with CDC25A. The peptide reduced prosurvival signaling, killed skin cancer cells and reduced skin tumor growth in xenograft. Normal skin keratinocytes were unaffected by inhibition or deletion of 14-3-3ε. Thus, targeting of 14-3-3ε dimerization is a promising strategy for the treatment of premalignant skin lesions.

A Case of Anti-TIF1-γ Antibody-positive Dermatomyositis with Cutaneous Squamous Cell Carcinoma

2018 ◽  
Vol 80 (4) ◽  
pp. 331-335
Author(s):  
Reika FUKUCHI ◽  
Sayaka KUWATSUKA ◽  
Yukie SATO ◽  
Yutaka KUWATSUKA ◽  
Atsushi UTANI
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma

Multidisciplinary Expert-Driven Consensus on the Evolving Treatment of Patients with Advanced Cutaneous Squamous Cell Carcinoma

2019 ◽  
Vol 3 ◽  
pp. S50
Author(s):  
Michael R Migden ◽  
Todd E Schlesinger ◽  
Chrysalyne D Schmults ◽  
Scott M Dinehart ◽  
Robert L Ferris ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma

Abstract not available.

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