scholarly journals A case of acute kidney injury caused by granulomatous interstitial nephritis associated with sarcoidosis

2017 ◽  
Vol 7 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Taro Horino ◽  
Tatsuki Matsumoto ◽  
Kosuke Inoue ◽  
Osamu Ichii ◽  
Yoshio Terada
Keyword(s):  
Acute Kidney Injury ◽  
Interstitial Nephritis ◽  
Kidney Injury ◽  
Granulomatous Interstitial Nephritis

scholarly journals Granulomatous interstitial nephritis in a patient with SARS-CoV-2 infection

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Katarzyna Szajek ◽  
Marie-Elisabeth Kajdi ◽  
Valerie A. Luyckx ◽  
Thomas Hans Fehr ◽  
Ariana Gaspert ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Interstitial Nephritis ◽  
Kidney Biopsy ◽  
Kidney Diseases ◽  
Case Reports ◽  
Kidney Injury ◽  
Maculopapular Rash ◽  
Tubular Injury ◽  
Granulomatous Interstitial Nephritis ◽  
First Case

Abstract Background Acute kidney injury (AKI) associated with severe coronavirus disease 19 (COVID-19) is common and is a significant predictor of morbidity and mortality, especially when dialysis is required. Case reports and autopsy series have revealed that most patients with COVID-19 – associated acute kidney injury have evidence of acute tubular injury and necrosis - not unexpected in critically ill patients. Others have been found to have collapsing glomerulopathy, thrombotic microangiopathy and diverse underlying kidney diseases. A primary kidney pathology related to COVID-19 has not yet emerged. Thus far direct infection of the kidney, or its impact on clinical disease remains controversial. The management of AKI is currently supportive. Case Presentation The patient presented here was positive for SARS-CoV-2, had severe acute respiratory distress syndrome and multi-organ failure. Within days of admission to the intensive care unit he developed oliguric acute kidney failure requiring dialysis. Acute kidney injury developed in the setting of hemodynamic instability, sepsis and a maculopapular rash. Over the ensuing days the patient also developed transfusion-requiring severe hemolysis which was Coombs negative. Schistocytes were present on the peripheral smear. Given the broad differential diagnoses for acute kidney injury, a kidney biopsy was performed and revealed granulomatous tubulo-interstitial nephritis with some acute tubular injury. Based on the biopsy findings, a decision was taken to adjust medications and initiate corticosteroids for presumed medication-induced interstitial nephritis, hemolysis and maculo-papular rash. The kidney function and hemolysis improved over the subsequent days and the patient was discharged to a rehabilitation facility, no-longer required dialysis. Conclusions Acute kidney injury in patients with severe COVID-19 may have multiple causes. We present the first case of granulomatous interstitial nephritis in a patient with COVID-19. Drug-reactions may be more frequent than currently recognized in COVID-19 and are potentially reversible. The kidney biopsy findings in this case led to a change in therapy, which was associated with subsequent patient improvement. Kidney biopsy may therefore have significant value in pulling together a clinical diagnosis, and may impact outcome if a treatable cause is identified.

scholarly journals Nitrofurantoin-Associated Acute Granulomatous Interstitial Nephritis

2021 ◽  
Vol 9 ◽  
pp. 232470962110016
Author(s):  
B. K. Anupama ◽  
Parth Sampat ◽  
Harvir S. Gambhir
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Case Report ◽  
Interstitial Nephritis ◽  
Visual Hallucination ◽  
Kidney Injury ◽  
Corticosteroid Administration ◽  
Granulomatous Interstitial Nephritis ◽  
Rare Association ◽  
New Onset

We report the case of a 71-year-old female who was incidentally found to have nonoliguric acute kidney injury on a routine workup for new-onset visual hallucination. Further history revealed inadvertent usage of nitrofurantoin for 3 months for an anticipated urological procedure. Renal biopsy demonstrated acute granulomatous interstitial nephritis. The renal function significantly improved following discontinuation of nitrofurantoin and corticosteroid administration. We highlight a rare association of nitrofurantoin with acute granulomatous interstitial nephritis through this case report.

scholarly journals Renal Sarcoidosis Presenting as Acute Kidney Injury with Granulomatous Interstitial Nephritis

2020 ◽  
Vol 08 (01) ◽  
pp. 7-9
Author(s):  
Nadia Bouchemla ◽  
Meriem Chettati ◽  
Poda Anselme ◽  
Meryem labrassi ◽  
Wafaa Fadili ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Interstitial Nephritis ◽  
Kidney Injury ◽  
Granulomatous Interstitial Nephritis

scholarly journals Acute kidney injury with granulomatous interstitial nephritis and vasculitis revealing sarcoidosis

2017 ◽  
Vol 28 (5) ◽  
pp. 1157 ◽  
Author(s):  
Amel Harzallah ◽  
Hayet Kaaroud ◽  
Karima Boubaker ◽  
Samia Barbouch ◽  
Rim Goucha ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Interstitial Nephritis ◽  
Kidney Injury ◽  
Granulomatous Interstitial Nephritis

scholarly journals Granulomatous Interstitial Nephritis Presenting as Hypercalcemia and Nephrolithiasis

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Saika Sharmeen ◽  
Esra Kalkan ◽  
Chunhui Yi ◽  
Steven D. Smith
Keyword(s):  
Primary Care ◽  
Acute Kidney Injury ◽  
Renal Failure ◽  
Interstitial Nephritis ◽  
Kidney Injury ◽  
Rare Entity ◽  
Past Medical History ◽  
Initial Manifestation ◽  
Granulomatous Interstitial Nephritis ◽  
Intravenous Hydration

We report a case of acute kidney injury as the initial manifestation of sarcoidosis. A 55-year-old male was sent from his primary care physician’s office with incidental lab findings significant for hypercalcemia and acute kidney injury with past medical history significant for nephrolithiasis. Initial treatment with intravenous hydration did not improve his condition. The renal biopsy subsequently revealed granulomatous interstitial nephritis (GIN). Treatment with the appropriate dose of glucocorticoids improved both the hypercalcemia and renal function. Our case demonstrates that renal limited GIN due to sarcoidosis, although a rare entity, can cause severe acute kidney injury and progressive renal failure unless promptly diagnosed and treated.

scholarly journals Acute kidney injury due to granulomatous interstitial nephritis induced by tramadol administration

2018 ◽  
Vol 38 (2) ◽  
pp. 227-228
Author(s):  
Francisco José Borrego Utiel ◽  
Rafael Luque Barona ◽  
Pilar Pérez del Barrio ◽  
Josefa Borrego Hinojosa ◽  
César Ramírez Tortosa
Keyword(s):  
Acute Kidney Injury ◽  
Interstitial Nephritis ◽  
Kidney Injury ◽  
Granulomatous Interstitial Nephritis
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