Thermosensitive nasal in situ gelling systems of rufinamide formulated using modified tamarind seed xyloglucan for direct nose-to-brain delivery: design, physical characterization, and in vivo evaluation

2021 ◽  
Author(s):  
Avantika V. Dalvi ◽  
Punna R. Ravi ◽  
Chandra T. Uppuluri ◽  
Radhika R. Mahajan ◽  
Sumeet V. Katke ◽  
...  
Keyword(s):  
Physical Characterization ◽  
Brain Delivery ◽  
In Vivo Evaluation ◽  
Tamarind Seed ◽  
In Situ Gelling

scholarly journals In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

2020 ◽  
Vol 10 (5-s) ◽  
pp. 32-39
Author(s):  
Fatima Eram ◽  
, Vivek
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Average Concentration ◽  
Posterior Segment ◽  
Ocular Infection ◽  
In Vivo Evaluation ◽  
Micro Emulsion ◽  
In Situ Gelling

Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e.  >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis. Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

scholarly journals Bimatoprost loaded nanovesicular long-acting sub-conjunctival in-situ gelling implant: In vitro and in vivo evaluation

2019 ◽  
Vol 103 ◽  
pp. 109730 ◽  
Author(s):  
Monika Yadav ◽  
Ana Guzman-Aranguez ◽  
Maria J. Perez de Lara ◽  
Mandeep Singh ◽  
Joga Singh ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Long Acting ◽  
In Situ Gelling

In vitro–in vivo evaluation of in situ gelling and thermosensitive ketoprofen liquid suppositories

2013 ◽  
Vol 39 (4) ◽  
pp. 283-291 ◽  
Author(s):  
Işık Özgüney ◽  
Anita Kardhiqi ◽  
Gülbeyaz Yıldız ◽  
Gökhan Ertan
Keyword(s):  
In Vivo Evaluation ◽  
In Situ Gelling

In vitro and in vivo evaluation of in situ gelling systems for sustained topical ophthalmic delivery: state of the art and beyond

2017 ◽  
Vol 22 (4) ◽  
pp. 638-651 ◽  
Author(s):  
Pierre-Louis Destruel ◽  
Ni Zeng ◽  
Marc Maury ◽  
Nathalie Mignet ◽  
Vincent Boudy
Keyword(s):  
State Of The Art ◽  
In Vivo Evaluation ◽  
Ophthalmic Delivery ◽  
In Situ Gelling

In vivo evaluation of risperidone-SAIB in situ system as a sustained release delivery system in rats

2008 ◽  
Vol 68 (2) ◽  
pp. 422-429 ◽  
Author(s):  
Yaxin Lu ◽  
Xing Tang ◽  
Yue Cui ◽  
Yu Zhang ◽  
Feng Qin ◽  
...  
Keyword(s):  
Sustained Release ◽  
Delivery System ◽  
In Vivo Evaluation
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