Effect of gastric residence time on the oral absorption of rebamipide sustained-release tablets in beagle dogs

2021 ◽  
Author(s):  
Su Hyun Seok ◽  
Jung-Myung Ha ◽  
Tae Hwan Kim ◽  
Gyoung-Won Kim ◽  
Byung Hoo Kim ◽  
...  
Keyword(s):  
Sustained Release ◽  
Residence Time ◽  
Oral Absorption ◽  
Beagle Dogs ◽  
Gastric Residence Time ◽  
Sustained Release Tablets

LC-ESI-MS Determination of Roxithromycin in Tissues of Beagle Dogs after Multiple Dosing of Roxithromycin Sustained Release Tablets

2007 ◽  
Vol 66 (7-8) ◽  
pp. 475-480 ◽  
Author(s):  
Weibin Zha ◽  
Jianguo Sun ◽  
Guangji Wang ◽  
Hongcan Ren ◽  
Xiaoling Hu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Beagle Dogs ◽  
Multiple Dosing ◽  
Esi Ms ◽  
Sustained Release Tablets

Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Beagle Dogs using the Bravo® pH System

2012 ◽  
Vol 101 (7) ◽  
pp. 2439-2448 ◽  
Author(s):  
Kelly M. Mahar ◽  
Samm Portelli ◽  
Robert Coatney ◽  
Emile P. Chen
Keyword(s):  
Residence Time ◽  
Gastric Ph ◽  
Beagle Dogs ◽  
Gastric Residence Time

Fed and fasted gastric pH and gastric residence time in conscious beagle dogs

2009 ◽  
Vol 98 (7) ◽  
pp. 2494-2500 ◽  
Author(s):  
Kazuko Sagawa ◽  
Fasheng Li ◽  
Ryan Liese ◽  
Steven C. Sutton
Keyword(s):  
Residence Time ◽  
Gastric Ph ◽  
Beagle Dogs ◽  
Gastric Residence Time

Development and Evaluation of Gastrobioadhesive Glimepiride Sustained Release Matrix Tablet Using Aegle Marmelos Polysaccharide

2020 ◽  
Vol 14 (1) ◽  
pp. 5297-5306
Author(s):  
M. A. Shende ◽  
Yogesh P Khedkar
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Residence Time ◽  
Diffusion Mechanism ◽  
Matrix Tablets ◽  
Fickian Diffusion ◽  
Matrix Tablet ◽  
Aegle Marmelos ◽  
Gastric Residence Time ◽  
Weight Variation

The purpose of present study was to formulate and evaluate glimepiride gastrobioadhesive drug delivery using Aegle Marmelos polysaccharide and synthetic polymer for prolongation of gastric residence time and reduce the dosing frequency. Glimepiride matrices were prepared by direct compression method and evaluated with an aim of presenting glimepiride as sustained release for improving the patient’s compliance. A central composite design (CCD) was employed as Aegle Marmelos polysaccharide (X1) and HPMC K4M (X2) independent variables to optimize the glimepiride in terms of sustained release and gastrobioadhesive. The response (Y1) as bioadhesive strength, (Y2) percentage drug releases at 8 h and (Y3) time (t50) required to 50% drug release were measured for each trial and statistical equations with significant interaction terms were derived to predict relation. The physical properties of all formulations hardness, friability, drug content and weight variation were found within limits indicating that the prepared matrix tablets met the USP specifications. Among all the formulations, F1 formulation found to be optimized based on the criteria of attaining the maximum value of drug released Q8 of 98.58±1.12%, 18.43 g bioadhesive strength and time to 50% drug release (t50) of 6 h. An in-vitro drug release studies reveals that as concentrations of polymers increases the drug release decreases, producing sustained release of glimepiride. The release co-efficient values ‘n’ (˂0.3645) indicated that the drug release (F1) followed fickian diffusion mechanism kinetics. A glimepiride gastroadhesive matrix was developed to enhance its bioavailability by prolonging the gastric residence time with desirable release modulation for a once daily administration.

Formulation and Evaluation of Sustained Release Dosage Forms of Norfloxacin

2018 ◽  
Vol 11 (6) ◽  
pp. 4331-4337
Author(s):  
C Suja ◽  
Sismy C
Keyword(s):  
Sustained Release ◽  
Guar Gum ◽  
In Vitro Release ◽  
Angle Of Repose ◽  
Prolonged Release ◽  
Weight Variation ◽  
Sustained Release Tablets ◽  
Release Study ◽  
Vitro Release

The goal of this study was to formulate and evaluate norfloxacin sustained release tablets. Norfloxacin sustained release tablets were prepared by wet granulation method using two polymers such as HPMC K 100 M (hydrophilic polymer) and guar gum (natural polymer) and with three polymer ratios (0.5, 1.0 and 1.5). The prepared granules were evaluated to preformulation studies such as angle of repose, bulk density, tapped density, bulkiness, compressibility index and Hauser’s ratio. All the parameters shows that the granules having good flow properties. Then the formulated tablets were taken to evaluation studies such as hardness, weight variation, friability, drug content and thickness. All the parameters were within the acceptable limits. IR spectral analysis showed that there was no interaction between the drug and polymers. The in vitro release study was performed in phosphate buffer pH 7.4 at 293 nm. The in vitro release study showed that if the polymer ratio is increased, then the release of the drug is prolonged. HPMC K 100M shows a prolonged release when compared to guar gum.

Crystal Transition and Drug-excipient Compatibility of Clarithromycin in Sustained Release Tablets

2020 ◽  
Vol 16 (7) ◽  
pp. 950-959
Author(s):  
Yu Li ◽  
Xiangwen Kong ◽  
Fan Hu
Keyword(s):  
Sustained Release ◽  
Powder Diffraction ◽  
Magnesium Stearate ◽  
Influential Factor ◽  
High Concentration ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Sustained Release Tablets ◽  
Crystal Transition ◽  
Excipient Compatibility

Background: Clarithromycin is widely used for infections of helicobacter pylori. Clarithromycin belongs to polymorphic drug. Crystalline state changes of clarithromycin in sustained release tablets were found. Objective: The aim of this study was to find the influential factor of the crystal transition of clarithromycin in preparation process of sustained-release tablets and to investigate the possible interactions between the clarithromycin and pharmaceutical excipients. Methods and Results: The crystal transition of active pharmaceuticals ingredients from form II to form I in portion in clarithromycin sustained release tablets were confirmed by x-ray powder diffraction. The techniques including differential scanning calorimetry and infrared spectroscopy, x-ray powder diffraction were used for assessing the compatibility between clarithromycin and several excipients as magnesium stearate, lactose, sodium carboxymethyl cellulose, polyvinyl-pyrrolidone K-30 and microcrystalline cellulose. All of these methods showed compatibilities between clarithromycin and the selected excipients. Alcohol prescription simulation was also done, which showed incompatibility between clarithromycin and concentration alcohol. Conclusion: It was confirmed that the reason for the incompatibility of clarithromycin with high concentration of alcohol was crystal transition.

Matrix Based Sustained Release Tablets of Carvedilol: Formulation and In-vitro Characterization

2018 ◽  
Vol 8 (2) ◽  
pp. 153-158
Author(s):  
Praveen Radhakrishnan ◽  
Shinu Chacko ◽  
Raman Saraswathi ◽  
Palamadai Neelakantam Krishnan
Keyword(s):  
Sustained Release ◽  
In Vitro Characterization ◽  
Sustained Release Tablets
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