Oxandrolone enhances growth hormone (GH) secretion and STIMULATES somatomedin C (SM-C) production in subjects with constitutional growth delay (CGD)

1986 ◽  
Vol 25 ◽  
pp. 22
Author(s):  
S. Loche ◽  
R. Corda ◽  
R. Puggioni ◽  
S.G. Cella ◽  
E.E. Müller ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Delay ◽  
Somatomedin C ◽  
Gh Secretion ◽  
Constitutional Growth Delay

Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa

2015 ◽  
Vol 28 (9-10) ◽  
Author(s):  
Silvia Ghione ◽  
Sandra Maestro ◽  
Eleonora Dati ◽  
Virginia Silvestri ◽  
Giampiero I. Baroncelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Anorexia Nervosa ◽  
Growth Delay ◽  
Psychiatric Assessment ◽  
Provocative Test ◽  
Energy Deficiency ◽  
Growth Impairment ◽  
Gh Secretion ◽  
Axis I ◽  
Criteria For Diagnosis

AbstractInfantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder.We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency.Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg/kg/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol.Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal/high GH levels and low IGF-1 values.

Results of 1-Year Growth Hormone (GH)-Releasing Hormone-(1-44) Treatment on Growth, Somatomedin-C, and 24-Hour GH Secretion in Six Children with Partial GH Deficiency

1987 ◽  
Vol 65 (2) ◽  
pp. 268-274 ◽  
Author(s):  
PIERRE E. ROCHICCIOLI ◽  
MARIE-THÈRÉSE TAUBER ◽  
FRANQOISXAVIER COUDE ◽  
MICHÉLE ARNONE ◽  
MICHEL MORRE ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Somatomedin C ◽  
Releasing Hormone ◽  
Gh Secretion

Plasma growth hormone (GH) and somatomedin C response to continuous growth hormone-releasing factor (GRF) infusion in patients with GH deficiency

1985 ◽  
Vol 110 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Naomi Hizuka ◽  
Kazue Takano ◽  
Kazuo Shizume ◽  
Izumi Tanaka ◽  
Noriko Honda ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Bolus Injection ◽  
Gh Deficiency ◽  
Saline Infusion ◽  
Pulse Area ◽  
Continuous Growth ◽  
Somatomedin C ◽  
Gh Secretion ◽  
The Mean ◽  
Plasma Gh

Abstract. Pituitary growth hormone (GH) responses during a 10-h iv infusion of saline or human GH-releasing factor (hGRF-44) at 500 ng/kg/h, followed by an iv bolus injection of hGRF-44 at 2 μg/kg body weight, were studied in 10 patients with GH deficiency. During saline infusion in 4 patients, small plasma GH increase were observed in 2 patients. However, during hGRF infusion in 6 patients, up to 4 or 13 pulses of GH secretion were observed. The mean integrated GH pulse area during hGRF infusion was 22.5 ± 5.2 (se) ng/ml × h, which was greater than that obtained during saline infusion. Plasma somatomedin C levels did not increase after hGRF infusion. After saline or hGRF infusion all patients responded to an iv bolus injection of the peptide. These results indicate that hGRF infusion augments GH secretion by increasing the number and amplitude of GH pulses and that the infusion does not cause pituitary somatotrophs to lose their capacity to respond to hGRF subsequently.

Effect of prolonged clonidine administration on growth hormone concentrations and rate of linear growth in children with constitutional growth delay

1986 ◽  
Vol 109 (5) ◽  
pp. 784-787 ◽  
Author(s):  
Mariano Castro-Magaña ◽  
Moris Angulo ◽  
Billy Fuentes ◽  
Maria Elena Castelar ◽  
Atilio Cañas ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Linear Growth ◽  
Growth Delay ◽  
Constitutional Growth Delay

scholarly journals Effects of Growth Hormone and Nutritional Therapy in Boys with Constitutional Growth Delay: A Randomized Controlled Trial

2011 ◽  
Vol 158 (3) ◽  
pp. 427-432 ◽  
Author(s):  
Joan C. Han ◽  
Ligeia Damaso ◽  
Susan Welch ◽  
Prabhakaran Balagopal ◽  
Jobayer Hossain ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Nutritional Therapy ◽  
Growth Delay ◽  
Randomized Controlled ◽  
Constitutional Growth Delay
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