Synchronization of the EEG and sedation induced by neuroleptics depend upon blockade of both D1 and D2 dopamine receptors

1988 ◽  
Vol 27 (8) ◽  
pp. 799-805 ◽  
Author(s):  
P BO ◽  
E ONGINI ◽  
A GIORGETTI ◽  
F SAVOLDI
Keyword(s):  
Dopamine Receptors ◽  
D2 Dopamine Receptors

pH dependence of sulpiride binding to D2 dopamine receptors in bovine brain

1991 ◽  
Vol 41 (6-7) ◽  
pp. R9-R12 ◽  
Author(s):  
Jeremy P. Presland ◽  
Philip G. Strange
Keyword(s):  
Dopamine Receptors ◽  
Ph Dependence ◽  
Bovine Brain ◽  
D2 Dopamine Receptors

Biochemical Properties of D1 and D2 Dopamine Receptors

1988 ◽  
pp. 33-41 ◽  
Author(s):  
Susan E. Senogles ◽  
Nourdine Amlaiky ◽  
Joel G. Berger ◽  
Marc G. Caron
Keyword(s):  
Dopamine Receptors ◽  
Biochemical Properties ◽  
D2 Dopamine Receptors

scholarly journals The glycosylation properties of D2 dopamine receptors from striatal and limbic areas of bovine brain

1988 ◽  
Vol 255 (3) ◽  
pp. 877-883 ◽  
Author(s):  
M N Leonard ◽  
R A Williamson ◽  
P G Strange
Keyword(s):  
Caudate Nucleus ◽  
Dopamine Receptors ◽  
Sodium Cholate ◽  
Bovine Brain ◽  
Affinity Column ◽  
Olfactory Tubercle ◽  
D2 Dopamine Receptors ◽  
Neuraminidase Treatment ◽  
Membrane Bound ◽  
Affinity Interaction

D2 dopamine receptors from bovine brain (caudate nucleus and olfactory tubercle) have been solubilized using sodium cholate/NaCl and their glycoprotein properties studied in terms of their interaction with wheat-germ agglutinin-agarose (WGA-agarose). Under optimal conditions about 65% of the applied D2 dopamine receptors bound to WGA-agarose and could be eluted with N-acetylglucosamine. The ability of receptors to adsorb to the affinity column was shown to be dependent on the cholate and salt concentrations used. Digestion of the membrane bound D2 dopamine receptors with neuraminidase prior to solubilisation reduced the ability of the receptors to bind to WGA-agarose (50% of applied receptors bound) whereas digestion with N-acetylglucosaminidase did not significantly affect binding to WGA-agarose. Digestion with the two enzymes together resulted in a larger decrease in binding to WGA-agarose than was seen with the two enzymes alone (40% of applied receptors bound). Stepwise elution of bound receptors from the WGA-agarose columns using 2.5 mM- and 100-mM-N-acetylglucosamine showed that about 40% of the bound receptors interacted with WGA-agarose in a low-affinity manner, the remainder showing a high-affinity interaction. Neuraminidase treatment reduced the low-affinity population suggesting that the interaction of oligosaccharides bearing sialic acid with WGA-agarose is of lower affinity and that higher-affinity binding is via N-acetylglucosamine. These data are discussed in terms of the heterogeneity of carbohydrate moieties on the D2 dopamine receptors within a brain region. In all the tests applied here, however, receptors from caudate nucleus and olfactory tubercle behaved identically so their glycosylation patterns must be very similar.

Chronic cocaine enhances defensive behaviour in the laboratory mouse: involvement of D2 dopamine receptors

1988 ◽  
Vol 96 (4) ◽  
pp. 437-441 ◽  
Author(s):  
Umberto Filibeck ◽  
Simona Cabib ◽  
Claudio Castellano ◽  
Stefano Puglisi-Allegra
Keyword(s):  
Dopamine Receptors ◽  
Laboratory Mouse ◽  
Defensive Behaviour ◽  
D2 Dopamine Receptors ◽  
Chronic Cocaine

Modification of the function of D1 and D2 dopamine receptors in striatum and nucleus accumbens of rats chronically treated with haloperidol

1987 ◽  
Vol 26 (5) ◽  
pp. 477-480 ◽  
Author(s):  
M. Memo ◽  
M. Pizzi ◽  
C. Missale ◽  
M.O. Carruba ◽  
P.F. Spano
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Receptors ◽  
D2 Dopamine Receptors

Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission

2007 ◽  
Vol 53 (6) ◽  
pp. 783-789 ◽  
Author(s):  
Alessandro Tozzi ◽  
Anne Tscherter ◽  
Vincenzo Belcastro ◽  
Michela Tantucci ◽  
Cinzia Costa ◽  
...  
Keyword(s):  
Dopamine Receptors ◽  
Glutamatergic Transmission ◽  
D2 Dopamine Receptors

F077 Inhibition of lysine residue of d2-dopamine receptors results in decrease dopaminergic and increase b-adrenergic effect

1998 ◽  
Vol 136 ◽  
pp. S66
Author(s):  
Gh. Naderi ◽  
S. Asgary ◽  
N. SarrafZadegan ◽  
M. Boshtam ◽  
M. Rafie
Keyword(s):  
Dopamine Receptors ◽  
Lysine Residue ◽  
D2 Dopamine Receptors
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