Mammary tumors from BALB/c mice with a reported high mammary tumor incidence have acquired new mammary tumor virus DNA sequences

Virology ◽  
1980 ◽  
Vol 100 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Vincent L. Morris ◽  
Janet E. Vlasschaert ◽  
Cynthia L. Beard ◽  
Mark F. Milazzo ◽  
Wayne C. Bradbury
Keyword(s):  
Mammary Tumor ◽  
Dna Sequences ◽  
Mammary Tumors ◽  
Tumor Incidence ◽  
Mammary Tumor Virus ◽  
Tumor Virus

scholarly journals Mammary tumors and mammary tumor virus expression in hybrid mice of strains C57BL and GR.

1977 ◽  
Vol 146 (5) ◽  
pp. 1206-1220 ◽  
Author(s):  
W E Heston ◽  
W P Parks
Keyword(s):  
Mammary Tumor ◽  
Dominant Gene ◽  
Mammary Tumorigenesis ◽  
Mammary Tumors ◽  
Tumor Incidence ◽  
C57bl Mouse ◽  
Mammary Tumor Virus ◽  
Gene Segregation ◽  
Tumor Virus ◽  
Virus Expression

Mammary tumorigenesis in genetic crosses between the high mammary tumor incidence GR and the low incidence C57BL mouse strains is highly correlated with murine mammary tumor virus expression in milk. Although the F1 and first backcross females had a mammary tumor incidence which was consistent with a single dominant gene segregation, the tumor incidence in the critical second backcross segregants disproved the single gene hypothesis. Genetic factors were clearly involved in regulation of virus expression which in turn correlated with both tumor incidence and tumor latency; these complex phenotypes are however best explained as threshold or quasicontinuous characters. As predicted from this model, the age specific incidence of mammary tumors showed a broad peak at 14-19 mo of age with no evidence of an early or late phase. Hematopoietic tumors showed no correlation with virus expression or mammary tumorigenesis suggesting different etiologies for these tumors.

Bioactivity of Male (Sperm Transmitted) Mouse Mammary Tumor Virus as Influenced by Donor, Recipient and Age at Treatment

1978 ◽  
Vol 64 (2) ◽  
pp. 103-114
Author(s):  
Francesco Squartini ◽  
Giancarlo Di Coscio
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumors ◽  
Male Parent ◽  
Tumor Incidence ◽  
Sperm Donor ◽  
Mammary Tumor Virus ◽  
Genetic Transmission ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

The sperm collected from mammary tumor virus (MTV)-carrying mice (C3H, BALB/cfC3H, BALB/cfRIII and RIII) was separately tested for mammary tumor-inducing activity in (BALB/c × C3Hf)F1, (BALB/c × RIIIf)F1, and BALB/c female recipients by i.p. injection of 0.1 ml of the sperm at 1–2 weeks or at 3 months of age. A total of 551 recipients was observed, including control mice. The results may be summarized as follows: 1) mammary tumor incidence in experiments with or without histocompatibility between sperm donor and recipient is the same; 2) bioactivity is related to the type of MTV (C3H, RIII) and to the type of recipient, not to the sperm donor; 3) the activity of RIII MTV released in the sperm appears to be less influenced by the age of recipients than is that of C3H MTV; 4) BALB/c recipients are more susceptible to C3H than to RIII sperm-released MTV; 5) (BALB/c × RIIIf)F1 hybrids are resistant to sperm-released MTV, especially to C3H MTV infection, and show a 34% incidence of late spontaneous lymphomas inherited by the RIIIf male parent; 6) (BALB/c × C3Hf)F1 hybrids are susceptible to both C3H and RIII sperm-released MTV and show a 30% incidence of late spontaneous mammary tumors due to genetic transmission of MTV by the C3Hf male parent.

scholarly journals Nucleosome-mediated disruption of transcription factor-chromatin initiation complexes at the mouse mammary tumor virus long terminal repeat in vivo.

1994 ◽  
Vol 14 (1) ◽  
pp. 32-41 ◽  
Author(s):  
H L Lee ◽  
T K Archer
Keyword(s):  
Mammary Tumor ◽  
Dna Sequences ◽  
Mouse Mammary Tumor Virus ◽  
Binding Protein ◽  
Tata Binding Protein ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Nuclear Factor 1

Glucocorticoid induction of mouse mammary tumor virus (MMTV) is short lived, returning to base levels within 24 h despite the continued presence of hormone. MMTV DNA sequences assembled as chromatin require hormone for binding by nuclear factor 1 (NF1) and octamer proteins (OCT). However, in the same cells, NF1 and OCT factors are bound to transiently introduced DNA in the absence of hormone. In contrast, recruitment of the TATA-binding protein and a novel DNA-binding protein, which we have designated FDT, for factor downstream of the TATA-binding protein, is hormone dependent for both stable and transient templates. Furthermore, transient DNA templates, but not nucleosomal templates, retain these transcription factors over the course of 24 h. This finding suggests that MMTV chromatin structure contributes to activation and cessation of transcription in vivo.

Mammary preneoplasia and tumorigenesis in the BALB/c mouse: structure and modification of mouse mammary tumor virus DNA sequences

1987 ◽  
Vol 7 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Miguel A. Gama-Sosa ◽  
Trudy Breznik ◽  
Janet S. Butel ◽  
Daniel Medina ◽  
J.Craig Cohen
Keyword(s):  
Mammary Tumor ◽  
Dna Sequences ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

scholarly journals Differential Distribution of Mouse Mammary Tumor Virus-Related Sequences in the DNA’s of Rats2

1979 ◽  
Vol 62 (5) ◽  
pp. 1279-1286
Author(s):  
W. Drohan ◽  
J. Schlom
Keyword(s):  
Mammary Tumor ◽  
Dna Sequences ◽  
Mouse Mammary Tumor Virus ◽  
Germ Line ◽  
Embryo Cell ◽  
Differential Distribution ◽  
Mammary Tumor Virus ◽  
Laboratory Rats ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

Abstract Radioactively labeled mouse mammary tumor virus (MuMTV) 60-70S RNA, obtained from virions grown In both murine and feline cells, was employed In molecular hybridization experiments to detect MuMTV-related sequences In the DNA’s of rats (Rattus norveglcus). With the use of relaxed conditions of hybridization and assay for RNA-DNA duplexes, all strains of laboratory rats and feral rats examined were shown to possess endogenous MuMTV-related DNA sequences In the low repetitive range. These sequences were related to approximately 20% of the MuMTV genome and exhibited a melting temperature (Tm) approximately 5° C lower than MuMTV-specific proviral sequences In murine (Mus musculus) DNA’s. Certain colonies of the F344 strain of rat (Fischer) contained animals whose DNA’s possessed additional MuMTV-related sequences. These sequences were related to the non-germ-line-transmitted, tumorassociated (TA) sequences of the highly oncogenic MuMTV (C3H). They were found In the DNA of some F344 rats and a cloned established F344 rat embryo cell line at a frequency of approximately one copy per haploid genome and exhibited a Tm 9° C lower than that of hybrid duplexes formed between radioactive MuMTV TA-sequence RNA and C3H mouse mammary tumor DNA. The DNA’s of rats, therefore, contained two sets of sequences that were related to sequences of the MuMTV genome: One set was germ-line transmitted, whereas the other set appeared to be transmitted in some rats via a non-germ line or infectious process.

Stability of Characters of Mammary Tumors in Balb/cfRIII Mice

1980 ◽  
Vol 66 (4) ◽  
pp. 439-444 ◽  
Author(s):  
Raffaele Pingitore
Keyword(s):  
Mammary Tumor ◽  
Morphological Characteristics ◽  
Mammary Tumors ◽  
Biological Properties ◽  
Mammary Tumor Virus ◽  
Tumor Virus

The biological and morphological characteristics of mammary tumors in BALB/c mice infected with RIII mammary tumor virus (MTV) by foster nursing have substantially kept stable and unchanged after 20 years, 53 inbred generations and transfer of the strain from Perugia to Pisa. This suggests that the causal MTV keeps unaltered in time its biological properties.

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