Age-associated changes in mitogen-induced lymphoproliferation and lymphokine production in the long-lived brown-norway rat: effect of caloric restriction

1995 ◽  
Vol 83 (2) ◽  
pp. 103-116 ◽  
Author(s):  
I.Michael Goonewardene ◽  
Donna M. Murasko
Keyword(s):  
Caloric Restriction ◽  
Brown Norway ◽  
Norway Rat ◽  
Lymphokine Production ◽  
Brown Norway Rat

scholarly journals Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries

2017 ◽  
Vol 312 (6) ◽  
pp. F971-F981 ◽  
Author(s):  
Fan Fan ◽  
Mallikarjuna R. Pabbidi ◽  
Ying Ge ◽  
Longyang Li ◽  
Shaoxun Wang ◽  
...  
Keyword(s):  
Vascular Reactivity ◽  
Vascular Dysfunction ◽  
Cerebral Arteries ◽  
Chromosome 1 ◽  
Brown Norway ◽  
Myogenic Response ◽  
Norway Rat ◽  
Vasoconstrictor Response ◽  
Brown Norway Rat ◽  
Interfering Rna

We have reported that the myogenic response of the renal afferent arteriole (Af-art) and middle cerebral artery (MCA) and autoregulation of renal and cerebral blood flow are impaired in Fawn-Hooded Hypertensive (FHH) rats. Transfer of a region of chromosome 1 containing γ-adducin (Add3) from the Brown Norway rat rescued the vascular dysfunction and the development of renal disease. To examine whether Add3 is a viable candidate gene altering renal and cerebral hemodynamics in FHH rats, we knocked down the expression of Add3 in rat Af-arts and MCAs cultured for 36-h using a 27-mer Dicer-substrate short interfering RNA (DsiRNA). Control Af-arts constricted by 10 ± 1% in response to an elevation in pressure from 60 to 120 mmHg but dilated by 4 ± 3% when treated with Add3 DsiRNA. Add3 DsiRNA had no effect on the vasoconstrictor response of the Af-art to norepinephrine (10−7 M). Add3 DsiRNA had a similar effect on the attenuation of the myogenic response in the MCA. Peak potassium currents were threefold higher in smooth muscle cells isolated from Af-arts or MCAs transfected with Add3 DsiRNA than in nontransfected cells isolated from the same vessels. This is the first study demonstrating that Add3 plays a role in the regulation of potassium channel function and vascular reactivity. It supports the hypothesis that sequence variants in Add3, which we previously identified in FHH rats, may play a causal role in the impaired myogenic response and autoregulation in the renal and cerebral circulation.

scholarly journals Age-Related Histological Changes in Kidneys of Brown Norway Rat

2014 ◽  
Vol 76 (2) ◽  
pp. 277-280 ◽  
Author(s):  
Akira YABUKI ◽  
Shinichiro YONESHIGE ◽  
Shin TANAKA ◽  
Masashi TSUJIO ◽  
Sawane MITANI ◽  
...  
Keyword(s):  
Brown Norway ◽  
Histological Changes ◽  
Norway Rat ◽  
Age Related ◽  
Brown Norway Rat
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