Stress and sucrose hyperphagia: Role of endogenous opiates

1984 ◽  
Vol 20 (5) ◽  
pp. 675-679 ◽  
Author(s):  
M.C. Bertiere ◽  
T. Mame Sy ◽  
F. Baigts ◽  
A. Mandenoff ◽  
M. Apfelbaum
Keyword(s):  
BMJ ◽  
1985 ◽  
Vol 290 (6470) ◽  
pp. 739-740 ◽  
Author(s):  
K De Meirleir ◽  
T Arentz ◽  
W Hollmann ◽  
L Vanhaelst

Neurosurgery ◽  
1984 ◽  
Vol 14 (4) ◽  
pp. 499-504
Author(s):  
Lincoln F. Ramirez ◽  
Allan B. Levin

Abstract Thirteen series of patients who underwent surgical or chemical hypophysectomy for the relief of pain associated with cancer were reviewed. In 10 series, involving 334 patients with breast or prostate cancer, surgical hypophysectomy produced pain relief in 70% of the patients afflicted with either tumor, including some with no evidence of hormone dependence. These results were then compared with the results of chemical hypophysectomy. This procedure was performed in 3 series involving 533 patients, of whom 24% had cancer other than breast or prostate. Chemical hypophysectomy produced pain relief in over 75% of the patients, regardless of tumor type or hormonal dependence. The possible role of the pituitary, the hypothalamus, and endogenous opiates in mediating the pain relief associated with hypophysectomy was examined. The mechanism by which pain relief is achieved remains unclear, but there is significant evidence that this relief is not related directly to the expected fall in the levels of known pituitary hormones. Evidence is provided that pain relief is the result of a hypothalamic pain-suppressing capability triggered by hypophy-sectomy. On the basis of both clinical data and the mechanism of action, we conclude that surgical and chemical hypophysectomy are fundamentally similar procedures.


1980 ◽  
Vol 59 (s6) ◽  
pp. 267s-269s ◽  
Author(s):  
Julianna E. Szilagyi ◽  
C. M. Ferrario

1. Intra-vertebral artery-administered angiotensin II acts at the area postrema to facilitate central sympathetic vasomotor activity. Recent evidence suggests a possible role of the opiate system in the mechanism of action of angiotensin II at the level of the brain stem. 2. In these experiments, we show that the morphine antagonist naloxone reduces significantly the magnitude of the pressor response to vertebral artery-infused angiotensin II. 3. Morphine, in contrast, doubled the peak of the vertebral response to identical doses of the peptide. Neither naloxone nor morphine affected the pressor responses to intravenously administered angiotensin II. 4. The data suggest that the endogenous opiate system in the medulla modulates the cardiovascular effects of angiotensin II at the level of the area postrema.


1990 ◽  
Vol 51 (6) ◽  
pp. 717-720 ◽  
Author(s):  
Laura De Marinis ◽  
Antonio Mancini ◽  
Colomba D’Amico ◽  
Francesco Calabró ◽  
Paolo Zuppi ◽  
...  

1984 ◽  
Vol 32 (3) ◽  
pp. 475-478 ◽  
Author(s):  
M'B. Essatara ◽  
J.E. Morley ◽  
A.S. Levine ◽  
M.K. Elson ◽  
R.B. Shafer ◽  
...  

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