Biological effects of folic acid antagonists with antineoplastic activity

1984 ◽  
Vol 25 (1) ◽  
pp. 61-82 ◽  
Author(s):  
R.C. Jackson
Keyword(s):  
Folic Acid ◽  
Biological Effects ◽  
Antineoplastic Activity ◽  
Folic Acid Antagonists

Potential folic acid antagonists. 6. Potential irreversible folate reductase inhibitors derived from 2,4-diamino-5-arylazopyrimidines

1971 ◽  
Vol 14 (12) ◽  
pp. 1244-1245 ◽  
Author(s):  
S. S. Chatterjee ◽  
J. F. Moran ◽  
D. J. Triggle ◽  
A. Wayne
Keyword(s):  
Folic Acid ◽  
Reductase Inhibitors ◽  
Folic Acid Antagonists

Risk of Fetal Exposure to Folic Acid Antagonists

2004 ◽  
Vol 26 (5) ◽  
pp. 475-479 ◽  
Author(s):  
Shi Wu Wen ◽  
Mark Walker
Keyword(s):  
Folic Acid ◽  
Fetal Exposure ◽  
Folic Acid Antagonists

Potential folic acid antagonists. VI. Syntheses of 1- and d 3-deazamethotrexate

1971 ◽  
Vol 36 (19) ◽  
pp. 2818-2823 ◽  
Author(s):  
Carroll Temple ◽  
Robert D. Elliott ◽  
Jerry L. Frye ◽  
John A. Montgomery
Keyword(s):  
Folic Acid ◽  
Folic Acid Antagonists

scholarly journals The effects of the folic acid antagonists and 2,6-diaminopurine on neoplastic disease.With special reference to acute leukemia

Cancer ◽  
1951 ◽  
Vol 4 (3) ◽  
pp. 549-569 ◽  
Author(s):  
Joseph H. Burchenal ◽  
David A. Karnofsky ◽  
Elizabeth M. Kingsley-Pillers ◽  
Chester M. Southam ◽  
W. P. Laird Myers ◽  
...  
Keyword(s):  
Folic Acid ◽  
Acute Leukemia ◽  
Special Reference ◽  
Folic Acid Antagonists

scholarly journals Folic acid – role in the body, recommendations and clinical significance

2019 ◽  
Vol 18 (1) ◽  
pp. 50-59 ◽  
Author(s):  
Aneta Myszczyszyn ◽  
Rafał Krajewski ◽  
Monika Ostapów ◽  
Lidia Hirnle
Keyword(s):  
Folic Acid ◽  
Biological Effects ◽  
Folic Acid Supplementation ◽  
The Body ◽  
Leafy Vegetables ◽  
Congenital Defects ◽  
Natural Form ◽  
Vitamin B9 ◽  
Increased Risk

AbstractIntroduction. Folic acid is a compound classified as B group vitamins. In the body it is subject to processes that transfer its inactive form into a form responsible for biological effects of folic acid, i.e. 5-methyltetrahydrofolate (5-MTHF). It is, in particular, responsible for processes of the correct biosynthesis of purine and pyridine bases present in the formation of DNA and RNA molecules. Humans do not synthesize the endogenous form of folic acid; therefore, it is vital to supplement this vitamin in its natural form or multivitamin preparations. The most folic acid is found in the green leafy vegetables (spinach, peas, asparagus) and in offal (liver). An adequate supply of folic acid is especially indicated in pregnant women with a reduced amount of folic acid due to its use by an intensively developing foetus. The recommended dose of folic acid during this period is 0.4 mg/24h and this dose varies depending on the patient’s and her family’s medical history. The updated state of knowledge on the role of vitamin B9 in the body has been presented. The importance of its supplementation in specific clinical cases was analyzed.Summary. Many studies indicate an important role of the folic acid in the prevention of congenital defects of the nervous, cardiovascular and urogenital systems. Its deficiency increases the risk of complications in pregnancy, such as recurrent miscarriages, pre-eclampsia or postpartum haemorrhage. For this reason, a prophylactic folic acid supplementation is recommended, in women with increased risk of its deficiency, in particular.

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