Inhibitors of metal catalyzed lipid peroxidation reactions inhibit mucus secretion and 15 hete levels in canine trachea

1987 ◽  
Vol 30 (2-3) ◽  
pp. 123-132 ◽  
Author(s):  
Herbert G. Johnson ◽  
Martha L. McNee ◽  
J. Mark Braughler
Keyword(s):  
Lipid Peroxidation ◽  
Mucus Secretion ◽  
Metal Catalyzed

scholarly journals Environmental Allergens House Dust Mites-induced Asthma Causes Ferroptosis in the Lungs

2021 ◽  
Author(s):  
Weifeng Tang ◽  
Ming Dong ◽  
Fangzhou Teng ◽  
Jie Cui ◽  
Xueyi Zhu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Allergic Asthma ◽  
House Dust ◽  
Inflammatory Cell ◽  
Morphological Changes ◽  
Mucus Secretion ◽  
House Dust Mites ◽  
Control Group ◽  
Dust Mites ◽  
Cell Counts

Abstract Background: Studies have indicated that allergens such as house dust mites (HDM) in the environment could induce allergic asthma. Ferroptosis is a newly discovered regulatory cell death characterized by aberrant lipid peroxidation and accumulation of reactive oxygen species (ROS) in cells. However, whether ferroptosis participates in the pathological progress of asthma remains to be elucidated. In this study, we used a HDM-induced mouse asthma model to determine the effect of HDM exposure on allergic asthma and the underlying mechanisms. Methods: Female BALB/c mice were intranasally exposed to HDM to induce allergic asthma. Airway hyperresponsiveness (AHR), lung inflammation and mucus secretion, IgE and cytokine levels as well as inflammatory cell counts in bronchalveolar lavage fluid (BALF) were investigated. In addition, the morphological changes of mitochondria, ROS, glutathione (GSH) levels and changes in ferroptosis pathway proteins in the lung were also determined. Results: HDM exposure increased AHR significantly, and enhanced inflammatory cell infiltration and mucus secretion around the airways. Furthermore, elevated IgE level in BALF, lung eosinophilia, and a concomitant increase in IL-13 and IL-5 in BALF were observed. HDM inhalation increased ROS and decreased GSH level in the lung. HDM inhalation induced dysmorphic small mitochondria with decreased crista, as well as condensed, ruptured outer membranes. Western blot analysis demonstrated that activity of glutathione peroxidase 4 (GPX4) and catalytic subunit solute carrier family 7 member 11 (SLC7A11) decreased significantly, and protein expression of acyl-CoA synthetase long-chain family member 4 (ACSL4) and 15 Lipoxygenase 1 (15-LO1) upregulated prominently compared with mice in normal control group. Conclusions: These in all indicated that the AHR, airway inflammation, lipid peroxidation and ROS level increased in HDM-induced asthma, and HDM inhalation caused ferroptosis in the lungs, which helped to form a better understanding of the pathogenesis of allergic asthma and targeted treatment strategies.

scholarly journals ANTIOXIDANT EFFECT OF DIPICOLINIC ACID ON THE METAL-CATALYZED LIPID PEROXIDATION AND ENZYME INACTIVATION

1998 ◽  
Vol 19 (3) ◽  
pp. 205-208 ◽  
Author(s):  
KEIKO MURAKAMI ◽  
TETSURO UEDA ◽  
RYO MORIKAWA ◽  
MASAE ITO ◽  
MIYAKO HANEDA ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dipicolinic Acid ◽  
Antioxidant Effect ◽  
Enzyme Inactivation ◽  
Metal Catalyzed

scholarly journals Metal-catalyzed oxidation of 2-alkenals generates genotoxic 4-oxo-2-alkenals during lipid peroxidation

2016 ◽  
Vol 80 (10) ◽  
pp. 2007-2013 ◽  
Author(s):  
Erika Nuka ◽  
Susumu Tomono ◽  
Akari Ishisaka ◽  
Yoji Kato ◽  
Noriyuki Miyoshi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Metal Catalyzed Oxidation ◽  
Metal Catalyzed ◽  
Catalyzed Oxidation

scholarly journals Antioxidant Effect of Capsaicinoids on the Metal-catalyzed Lipid Peroxidation

2001 ◽  
Vol 22 (1) ◽  
pp. 15-17 ◽  
Author(s):  
KEIKO MURAKAMI ◽  
MASAE ITO ◽  
HLA HLA HTAY ◽  
RYOKO TSUBOUCHI ◽  
MASATAKA YOSHINO
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Effect ◽  
Metal Catalyzed

scholarly journals Protective Effect of 3,4-Methylenedioxyphenol (Sesamol) on Stress-Related Mucosal Disease in Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Dur-Zong Hsu ◽  
Yi-Wei Chen ◽  
Pei-Yi Chu ◽  
Srinivasan Periasamy ◽  
Ming-Yie Liu
Keyword(s):  
Lipid Peroxidation ◽  
Gastric Mucosa ◽  
Proinflammatory Cytokines ◽  
Water Immersion ◽  
Gastric Ulceration ◽  
Mucus Secretion ◽  
Nuclear Factor ◽  
Mucosal Disease ◽  
Considerable Morbidity ◽  
Necrosis Factor

Stress-related mucosal disease (SRMD) causes considerable morbidity and mortality in critically ill patients. 3,4-Methylenedioxyphenol (sesamol) has been reported to have potent antioxidative and anti-inflammatory properties. The aim of this study was to investigate the effect of sesamol on water immersion restraint- (WIR-) induced SRMD in rats. Rat gastric ulcer and hemorrhage were induced by WIR. Rats were pretreated orally with various doses of sesamol (0.1, 0.3, and 1 mg/kg, resp.) 30 min before WIR. Gastric mucosal ulceration, hemoglobin, lipid peroxidation, mucus secretion, proinflammatory cytokines, and nuclear factor (NF)-κB levels were determined 4 h after WIR. In addition, the infiltration of neutrophil and macrophage into gastric mucosa was also determined after WIR. Water immersion restraint increased gastric mucosal ulcer and hemorrhage, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 levels but failed to affect mucosal lipid peroxidation and mucus secretion compared with non-WIR. Sesamol significantly decreased gastric ulceration and hemorrhage and inhibited mucosal TNF-α, IL-1β, and IL-6 production and NF-κB activity in WIR-treated rats. In addition, increased myeloperoxidase and CD68 levels in gastric mucosa were found in WIR-treated rats compared to non-WIR rats. Sesamol did not affect myeloperoxidase but decreased CD68 levels in mucosa in WIR-treated rats. Sesamol may protect against SRMD by inhibiting gastric mucosal proinflammatory cytokines in rats.

Effects of quinine on gastric ulcer healing in Wistar rats

2017 ◽  
Vol 14 (4) ◽  
Author(s):  
Olasupo Stephen Adeniyi ◽  
Olubiyi Vincent Makinde ◽  
Emmanuel Titus Friday ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Wistar Rats ◽  
Superoxide Dismutase Activity ◽  
Mucus Secretion ◽  
Gastric Mucus ◽  
Inflammatory Phase ◽  
Significant Difference

AbstractBackgroundQuinine (QT) is an important anti-malarial drug; however, there is little information about its effects on the gut. Therefore, this study aimed to investigate the effects of a therapeutic dose of QT on the healing of gastric ulcer in rats.MethodsMale Wistar rats weighing 150–200 g were divided into three groups: control rats without ulcer (group 1), ulcerated rats treated with 1 mL/kg (p.o.) normal saline (NS) (group 2), and ulcerated rats treated with 10 mg/kg (p.o.) QT (group 3). Ulcers were induced by serosal application of 80 % acetic acid to the stomach of rats anaesthetized with 50 mg/kg thiopentone sodium and treatment was given three times daily. Healing was assessed on days 3, 7 and 10 after ulcer induction by macroscopic measurement of: ulcer area, histology, lipid peroxidation, superoxide dismutase activity and gastric mucus secretion.ResultsAt day 3, there was no significant difference (p>0.05) in ulcer areas between NS- and QT-treated rats. By day 10, however, the percentage area healed in NS treated (59.6±2.35 %) was significantly higher (p<0.05) than in QT rats (49.0±2.20 %) and clearing of inflammatory cells and re-epithelization was greater in NS-treated group. By days 7 and 10, lipid peroxidation was significantly higher in QT animals, when compared with NS-treated rats and controls (p<0.05). Superoxide dismutase activity and mucus secretion were significantly (p<0.05) higher in NS-treated than QT-treated rats.ConclusionsQT delayed ulcer healing by prolonging the inflammatory phase of healing, increasing oxidative stress, reducing antioxidant activity and gastric mucus secretion

Chelation-assisted transition metal-catalysed C–H chalcogenylations

2020 ◽  
Vol 7 (8) ◽  
pp. 1022-1060 ◽  
Author(s):  
Wenbo Ma ◽  
Nikolaos Kaplaneris ◽  
Xinyue Fang ◽  
Linghui Gu ◽  
Ruhuai Mei ◽  
...  
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Site Selectivity ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.

Peptides derived from casein induce mucus secretion in rat jejunum: Involvement of opioid stimulation

2001 ◽  
Vol 120 (5) ◽  
pp. A675-A675
Author(s):  
F TOUMI ◽  
J CLAUSTRE ◽  
A TROMPETTE ◽  
G JOURDAN ◽  
H GUIGNARD ◽  
...  
Keyword(s):  
Mucus Secretion ◽  
Rat Jejunum

In vivo lipid peroxidation and platelet activation in Helicobacter pylori infection

2001 ◽  
Vol 120 (5) ◽  
pp. A670-A670
Author(s):  
M NERI ◽  
G DAVI ◽  
D FESTI ◽  
F LATERZA ◽  
A FALCO ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Helicobacter Pylori ◽  
Platelet Activation ◽  
Helicobacter Pylori Infection
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