Role of human recombinant GM-CSF in the prevention and treatment of leukopenia with special reference to infectious diseases

1990 ◽  
Vol 13 (5) ◽  
pp. 391-396 ◽  
Author(s):  
Angelika C. Stern ◽  
Thomas C. Jones
2019 ◽  
Vol 96 (8) ◽  
pp. 789-792
Author(s):  
R. U. Khabriev ◽  
Boris A. Spasennikov ◽  
L. F. Pertli ◽  
S. A. Kopytkin

The article considers the historical aspect of sanitary development in the domestic penitentiary system. In 1788, the Regulations on Prisons were adopted, in which the sanitary requirements of the penitentiary systems of European states were used. Since 1819, the Ministry of Internal Affairs of the Russian Empire organized sanitary affair. This provided the conditions for the development of penitentiary sanitation. The legal basis for sanitation for prisoners was established in 1831. In 1850 in prison died 1598 criminals of a 980,000 who were in prison (0.16%). This is evidence of a good level of sanitation in Russia at this time. In 1879, the Chief Prison Directorate of the Russian Empire appointed an inspector for the sanitary unit. He developed sanitary measures and coordinated their implementation. The role of professor A.P. Dobroslavina is shown in the development of penitentiary hygiene and sanitation. The primary link of the domestic penitentiary system was the administration of prisons. According to the law of June 15, 1887, doctors and paramedics were assigned to them. They organized and conducted sanitary measures. Treatment of sick prisoners and sanitation was carried out at the expense of the state. It was revealed that more attention was paid to the prevention and treatment of infectious diseases. Normative sanitary acts in the penitentiary system must have mandatory for the administration of places of detention. For the purposes of sanitary and epidemiological well-being, it is not possible to subordinate medical workers to the prison director. This was provided for by the General Prison Regulations of 1915. But, unfortunately, has not been implemented so far. The authors believe that the time has come to implement this norm in practice.


2020 ◽  
Vol 3 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Russel J Reiter ◽  
Qiang Ma ◽  
Ramaswamy Sharma

This review summarizes published reports on the utility of melatonin as a treatment for virus-mediated diseases. Of special note are the data related to the role of melatonin in influencing Ebola virus disease. This infection and deadly condition has no effective treatment and the published works documenting the ability of melatonin to attenuate the severity of viral infections generally and Ebola infection specifically are considered. The capacity of melatonin to prevent one of the major complications of an Ebola infection, i.e., the hemorrhagic shock syndrome, which often contributes to the high mortality rate, is noteworthy. Considering the high safety profile of melatonin, the fact that it is easily produced, inexpensive and can be self-administered makes it an attractive potential treatment for Ebola virus pathology.  


2018 ◽  
Vol 18 (7) ◽  
pp. 985-992 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Ertan Kucuksayan ◽  
Rana Cagla Akduman ◽  
Tomris Ozben

This systematic review aims to elucidate the role of melatonin (N-acetyl-5-metoxy-tryptamine) (MLT) in the prevention and treatment of cancer. MLT is a pineal gland secretory product, an evolutionarily highly conserved molecule; it is also an antioxidant and an impressive protector of mitochondrial bioenergetic activity. MLT is characterized by an ample range of activities, modulating the physiology and molecular biology of the cell. Its physiological functions relate principally to the interaction of G Protein-Coupled MT1 and MT2 trans-membrane receptors (GPCRs), a family of guanidine triphosphate binding proteins. MLT has been demonstrated to suppress the growth of various tumours both, in vivo and in vitro. In this review, we analyze in depth, the antioxidant activity of melatonin, aiming to illustrate the cancer treatment potential of the molecule, by limiting or reversing the changes occurring during cancer development and growth.


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