scholarly journals Characterization of proteins by means of their buffer capacity, measured with an ISFET-based coulometric sensor—actuator system

1994 ◽  
Vol 9 (9-10) ◽  
pp. 743-751 ◽  
Author(s):  
W. Olthuis ◽  
J. Luo ◽  
P. Bergveld
2020 ◽  
Vol 48 (20) ◽  
pp. 11799-11811
Author(s):  
Natascha Gödecke ◽  
Jan Riedel ◽  
Sabrina Herrmann ◽  
Sara Behme ◽  
Ulfert Rand ◽  
...  

Abstract Mammalian first line of defense against viruses is accomplished by the interferon (IFN) system. Viruses have evolved numerous mechanisms to reduce the IFN action allowing them to invade the host and/or to establish latency. We generated an IFN responsive intracellular hub by integrating the synthetic transactivator tTA into the chromosomal Mx2 locus for IFN-based activation of tTA dependent expression modules. The additional implementation of a synthetic amplifier module with positive feedback even allowed for monitoring and reacting to infections of viruses that can antagonize the IFN system. Low and transient IFN amounts are sufficient to trigger these amplifier cells. This gives rise to higher and sustained—but optionally de-activatable—expression even when the initial stimulus has faded out. Amplification of the IFN response induced by IFN suppressing viruses is sufficient to protect cells from infection. Together, this interfaced sensor/actuator system provides a toolbox for robust sensing and counteracting viral infections.


2018 ◽  
Vol 30 (4) ◽  
pp. 636-648 ◽  
Author(s):  
Philipp Linnebach ◽  
Filomena Simone ◽  
Gianluca Rizzello ◽  
Stefan Seelecke

Dielectric elastomers represent a relatively new technology with high potentials for actuators’ applications. Thanks to their lightweight, fast operations, energy efficiency, low power consumption, large deformations, and high scalability, dielectric elastomers permit to develop novel mechatronic systems capable of overperforming standard actuation technologies, such as solenoid valves, in several applications. This article presents a novel design for a dielectric elastomer–driven actuator system which enables closing and opening of a contactor. The design is based on a combination between circular out-of-plane dielectric elastomer membranes and a bi-stable biasing system which allows to increase the out-of-plane stroke. Characterization of the contactor is initially performed in order to establish the actuator requirements in terms of force and stroke. Then, systematic design and manufacturing are carried out for both dielectric elastomer membranes and biasing mechanism. Finally, the effectiveness of the actuator in closing and opening the contactor is validated experimentally. The results show comparable dynamic performance to a conventional electromagnetic drive, with the additional advantage of a significantly lower energy consumption.


2015 ◽  
Vol 88 ◽  
pp. 91-99 ◽  
Author(s):  
M. Rahim ◽  
O. Douzane ◽  
A.D. Tran Le ◽  
G. Promis ◽  
B. Laidoudi ◽  
...  

2007 ◽  
Vol 19 (3) ◽  
pp. 035506 ◽  
Author(s):  
J F C Windmill ◽  
A Zorab ◽  
D J Bedwell ◽  
D Robert

1991 ◽  
Vol 5 (1-4) ◽  
pp. 47-52 ◽  
Author(s):  
W. Olthuis ◽  
J.G. Bomer ◽  
P. Bergveld ◽  
M. Bos ◽  
W.E. van der Linden

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