Fish and Shellfish Poisoning

2017 ◽  
pp. 451-456
Author(s):  
Elaine C. Jong
Keyword(s):  
Shellfish Poisoning ◽  
Fish And Shellfish

Fish and Shellfish Poisoning

1976 ◽  
Vol 295 (20) ◽  
pp. 1117-1120 ◽  
Author(s):  
James M. Hughes ◽  
Michael H. Merson
Keyword(s):  
Shellfish Poisoning ◽  
Fish And Shellfish

scholarly journals Structural basis for the modulation of voltage-gated sodium channels by animal toxins

Science ◽  
2018 ◽  
Vol 362 (6412) ◽  
pp. eaau2596 ◽  
Author(s):  
Huaizong Shen ◽  
Zhangqiang Li ◽  
Yan Jiang ◽  
Xiaojing Pan ◽  
Jianping Wu ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Structural Basis ◽  
Shellfish Poisoning ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Puffer Fish ◽  
Gating Modifier ◽  
Extracellular Side ◽  
Fish And Shellfish ◽  
Shed Light

Animal toxins that modulate the activity of voltage-gated sodium (Nav) channels are broadly divided into two categories—pore blockers and gating modifiers. The pore blockers tetrodotoxin (TTX) and saxitoxin (STX) are responsible for puffer fish and shellfish poisoning in humans, respectively. Here, we present structures of the insect Navchannel NavPaS bound to a gating modifier toxin Dc1a at 2.8 angstrom-resolution and in the presence of TTX or STX at 2.6-Å and 3.2-Å resolution, respectively. Dc1a inserts into the cleft between VSDIIand the pore of NavPaS, making key contacts with both domains. The structures with bound TTX or STX reveal the molecular details for the specific blockade of Na+access to the selectivity filter from the extracellular side by these guanidinium toxins. The structures shed light on structure-based development of Navchannel drugs.

Detection of Ciguatera and Diarrheic Shellfish Toxins in Finfish and Shellfish With Ciguatect Kit

1995 ◽  
Vol 78 (2) ◽  
pp. 533-537 ◽  
Author(s):  
Douglas L Park
Keyword(s):  
Okadaic Acid ◽  
Solid Phase ◽  
Rapid Screening ◽  
Enzyme Linked Immunosorbent Assay ◽  
Shellfish Poisoning ◽  
Fish Flesh ◽  
Test Kit ◽  
User Friendly ◽  
Fish And Shellfish ◽  
Dsp Toxins

Abstract The Ciguatect test kit for the detection of ciguatoxin, okadaic acid, and related polyether compounds, based on solid-phase immunobead assay technology, was developed for rapid screening of toxic fish and shellfish in harvesting areas and the marketplace. Earlier formats, based on radioimmunoassay and enzyme-linked immunosorbent assay (ELISA) technology, were used successfully to identify and separate ciguatoxic fish harvested from Hawaiian waters. The new format utilizes a membrane attached to a plastic strip, immunobead solution, and a user-friendly readout. Multiple formats of the test kit, including a rapid extraction method (REM) and ELISA, were demonstrated to be more sensitive than the mouse assay for detection of ciguatera-related compounds. Depending on the format used, the level of detection can be as low as 50 pg okadaic acid per gram of tissue. The test kit has been used to map ciguatoxic and nontoxic fishing areas around the islands of Hawaii through the use of a biomarker and the monitoring of toxic fish obtained from Pacific and Caribbean regions. Ciguatera-related toxins can be detected directly on fish flesh or after extraction by traditional procedures or the newly developed REM. Initial applications of the test kit to monitor diarrheic shellfish poisoning (DSP)-related toxins in mussels before, during, and after Dinophysis sp. blooms and during depuration operations were successful. The Ciguatect methodology can be used to monitor reef fishing areas for ciguatera potential, shellfish beds for DSP toxins, and shellfish depuration operations for elimination of DSP toxins and to screen for toxic fish and shellfish in the marketplace.

Poisoning and envenoming

2021 ◽  
pp. 813-838
Author(s):  
Michael Eddleston ◽  
David Warrell
Keyword(s):  
Acute Poisoning ◽  
Snake Bite ◽  
Mushroom Poisoning ◽  
Pesticide Poisoning ◽  
Shellfish Poisoning ◽  
Scorpion Sting ◽  
Methanol Poisoning ◽  
Spider Bite ◽  
Fish And Shellfish ◽  
Acute Pesticide Poisoning

Acute poisoning?, Acute pesticide poisoning?, Organophosphates/carbamates?, Acute poisoning with pharmaceuticals/chemicals?, Mushroom poisoning?, Methanol poisoning?, Fish and shellfish poisoning?, Snake bite?, Scorpion sting?, Spider bite?, Fish stings?, Jelly fish stings?

Fish and Shellfish Poisoning in Britain

1982 ◽  
pp. 297-306 ◽  
Author(s):  
P. C. B. Turnbull ◽  
R. J. Gilbert
Keyword(s):  
Shellfish Poisoning ◽  
Fish And Shellfish
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