Pharmacology of Benzodiazepine Receptor Agonist Hypnotics

2012 ◽  
pp. 99-108
Author(s):  
Timothy A. Roehrs ◽  
Christina Diederichs ◽  
Thomas Roth
Keyword(s):  
Receptor Agonist ◽  
Benzodiazepine Receptor ◽  
Benzodiazepine Receptor Agonist

scholarly journals The Effect of Two Benzodiazepine Receptor Agonist Hypnotics on Sleep-Dependent Memory Consolidation

2014 ◽  
Vol 10 (01) ◽  
pp. 27-34 ◽  
Author(s):  
Janine M. Hall-Porter ◽  
Paula K. Schweitzer ◽  
Rhody D. Eisenstein ◽  
Hasan Ali H. Ahmed ◽  
James K. Walsh
Keyword(s):  
Memory Consolidation ◽  
Receptor Agonist ◽  
Benzodiazepine Receptor ◽  
Benzodiazepine Receptor Agonist

scholarly journals Inhibition of Morphine-Induced Tolerance and Dependence by a Benzodiazepine Receptor Agonist Midazolam in the Rat

1993 ◽  
Vol 76 (5) ◽  
pp. 1052???1060 ◽  
Author(s):  
Gopi A. Tejwani ◽  
Anil K. Rattan ◽  
Pongruk Sribanditmongkol ◽  
Ming-Jyh Sheu ◽  
Jorge Zuniga ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Benzodiazepine Receptor ◽  
Benzodiazepine Receptor Agonist ◽  
Induced Tolerance

scholarly journals Pharmacological Effects of Benzodiazepine Receptor Agonist on the General Behavior in Mice.

2000 ◽  
Vol 26 (1) ◽  
pp. 44-51
Author(s):  
MASATO HOZUMI ◽  
MICHINAO MIZUGAKI ◽  
NOBUNORI SATOH ◽  
TAKESHI TADANO ◽  
KENSUKE KISARA
Keyword(s):  
Receptor Agonist ◽  
Benzodiazepine Receptor ◽  
Pharmacological Effects ◽  
General Behavior ◽  
Benzodiazepine Receptor Agonist

scholarly journals JM-1232(-) and propofol, a new combination of anesthetics with short-acting and non-cumulative preferable properties

2019 ◽  
Author(s):  
Yushi Ueda Adachi ◽  
Saori Taharabaru ◽  
Michiko Higashi ◽  
Naoyuki Matsuda ◽  
Maiko Satomoto ◽  
...  
Keyword(s):  
Recovery Time ◽  
Receptor Agonist ◽  
Benzodiazepine Receptor ◽  
New Combination ◽  
Additive Interaction ◽  
Male Adult ◽  
Adult Mice ◽  
Righting Reflex ◽  
Benzodiazepine Receptor Agonist ◽  
Hypnotic Dose

Abstract Background Drug interactions are significant in anesthesiology because drug combinations can potentially possess novel properties. The pharmacological advantages of a new combination of the benzodiazepine receptor agonist JM-1232(-) and propofol were investigated in mice.Methods Male adult mice were administered JM-1232(-) or propofol or combinations of the two drugs intravenously. Loss of the righting reflex was evaluated as achieving hypnosis, and the time until recovery of the reflex was measured as hypnosis time. After determining the ED50, doses double and triple the ED50 of propofol were injected with JM-1232(-) to compare hypnosis time. The injections were repeated four times, and the hypnosis times were compared. Flumazenil was administered separately immediately after the last dose was injected.Results The ED50 values ([95% confidence interval]) for hypnosis were 3.76 [3.36–4.10] for JM-1232(-) and 9.88 [8.03–11.58] mg kg-1 for propofol. Co-administration of 0.05 and 0.1 mg kg-1 JM-1232(-) reduced the ED50 values of propofol to 1.76 [1.21–2.51] and 1.00 [0.46–1.86] mg kg-1, respectively. The drug combination for hypnosis produced a supra-additive interaction. Hypnosis time was significantly shorter in the groups given the mixtures compared to each hypnotic administered alone. After repeated injections, hypnosis time with the mixtures showed smaller prolongation than that with the hypnotic alone. Flumazenil completely restored the recovery time after anesthesia.Conclusions The combination of JM-1232(-) and propofol showed a supra-additive interaction, and the reduced hypnotic dose contributed to a faster recovery even after multiple injections.

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