THE ROLE OF THE MESOLIMBIC DOPAMINE SYSTEM IN LOCOMOTOR ACTIVITY, EATING AND DRINKING IN THE RAT

Author(s):  
GEORGE F. KOOB ◽  
TREVOR W. ROBBINS
1976 ◽  
Vol 35 (1) ◽  
pp. 45-58 ◽  
Author(s):  
A.J.J. Pijnenburg ◽  
W.M.M. Honig ◽  
J.A.M. Van Der Heyden ◽  
J.M. Van Rossum

2008 ◽  
Vol 1139 (1) ◽  
pp. 307-317 ◽  
Author(s):  
Marco Diana ◽  
Alessandra Tiziana Peana ◽  
Donatella Sirca ◽  
Alessandra Lintas ◽  
Miriam Melis ◽  
...  

2018 ◽  
Vol 43 (8) ◽  
pp. 1651-1659 ◽  
Author(s):  
Dana Mayer ◽  
Evelyn Kahl ◽  
Taygun C. Uzuneser ◽  
Markus Fendt

2020 ◽  
Vol 52 (12) ◽  
pp. 1879-1890
Author(s):  
Ja-Hyun Baik

AbstractDopamine regulates reward-related behavior through the mesolimbic dopaminergic pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the mesolimbic dopamine system. Changes in mesolimbic dopaminergic neurotransmission are important for coping with stress, as they allow adaption to behavioral responses to various environmental stimuli. Upon stress exposure, modulation of the dopaminergic reward system is necessary for monitoring and selecting the optimal process for coping with stressful situations. Aversive stressful events may negatively regulate the dopaminergic reward system, perturbing reward sensitivity, which is closely associated with chronic stress-induced depression. The mesolimbic dopamine system is excited not only by reward but also by aversive stressful stimuli, which adds further intriguing complexity to the relationship between stress and the reward system. This review focuses on lines of evidence related to how stress, especially chronic stress, affects the mesolimbic dopamine system, and discusses the role of the dopaminergic reward system in chronic stress-induced depression.


2013 ◽  
Vol 39 (3) ◽  
pp. 614-624 ◽  
Author(s):  
Michael D Leitl ◽  
Sara Onvani ◽  
M Scott Bowers ◽  
Kejun Cheng ◽  
Kenner C Rice ◽  
...  

2014 ◽  
Vol 4 (2) ◽  
pp. e361-e361 ◽  
Author(s):  
F J Meye ◽  
G M J Ramakers ◽  
R A H Adan

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