In vitro and in vivo studies of electroactive reduced graphene oxide-modified nanofiber scaffolds for peripheral nerve regeneration

2019 ◽  
Vol 84 ◽  
pp. 98-113 ◽  
Author(s):  
Juan Wang ◽  
Yuan Cheng ◽  
Liang Chen ◽  
Tonghe Zhu ◽  
Kaiqiang Ye ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Reduced Graphene Oxide ◽  
Peripheral Nerve Regeneration ◽  
In Vivo Studies ◽  
Reduced Graphene ◽  
Nanofiber Scaffolds

scholarly journals The influence of reduced graphene oxide on stem cells: a perspective in peripheral nerve regeneration

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Xiangyun Yao ◽  
Zhiwen Yan ◽  
Xu Wang ◽  
Huiquan Jiang ◽  
Yun Qian ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Graphene Oxide ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Reduced Graphene Oxide ◽  
Peripheral Nerve Regeneration ◽  
Embryonic Stem ◽  
Composite Scaffolds ◽  
Reduced Graphene

Abstract Graphene and its derivatives are fascinating materials for their extraordinary electrochemical and mechanical properties. In recent decades, many researchers explored their applications in tissue engineering and regenerative medicine. Reduced graphene oxide (rGO) possesses remarkable structural and functional resemblance to graphene, although some residual oxygen-containing groups and defects exist in the structure. Such structure holds great potential since the remnant-oxygenated groups can further be functionalized or modified. Moreover, oxygen-containing groups can improve the dispersion of rGO in organic or aqueous media. Therefore, it is preferable to utilize rGO in the production of composite materials. The rGO composite scaffolds provide favorable extracellular microenvironment and affect the cellular behavior of cultured cells in the peripheral nerve regeneration. On the one hand, rGO impacts on Schwann cells and neurons which are major components of peripheral nerves. On the other hand, rGO-incorporated composite scaffolds promote the neurogenic differentiation of several stem cells, including embryonic stem cells, mesenchymal stem cells, adipose-derived stem cells and neural stem cells. This review will briefly introduce the production and major properties of rGO, and its potential in modulating the cellular behaviors of specific stem cells. Finally, we present its emerging roles in the production of composite scaffolds for nerve tissue engineering.

Reduced graphene oxide–GelMA–PCL hybrid nanofibers for peripheral nerve regeneration

2020 ◽  
Vol 8 (46) ◽  
pp. 10593-10601
Author(s):  
Xingxing Fang ◽  
Haichang Guo ◽  
Wei Zhang ◽  
Haoming Fang ◽  
Qicheng Li ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Graphene Oxide ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Reduced Graphene Oxide ◽  
Peripheral Nerve Regeneration ◽  
Cell Behaviors ◽  
Hybrid Nanofibers ◽  
Reduced Graphene

Graphene oxide is currently used in peripheral nerve engineering but has certain limitations, such as cytotoxicity and lack of electrical conductivity, both of which are crucial in regulating nerve-associated cell behaviors.

Pluronic® F127 stabilized reduced graphene oxide hydrogel for the treatment of psoriasis: In vitro and in vivo studies

2020 ◽  
Vol 195 ◽  
pp. 111246
Author(s):  
Qiang Li ◽  
Fangmei Li ◽  
Xixi Qi ◽  
Fuqiao Wei ◽  
Hongxiao Chen ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
In Vivo Studies ◽  
Reduced Graphene

Effect of Astragalus membranaceus in Rats on Peripheral Nerve Regeneration: In Vitro and In Vivo Studies

2010 ◽  
Vol 68 (2) ◽  
pp. 434-440 ◽  
Author(s):  
Ming-Chin Lu ◽  
Chun-Hsu Yao ◽  
Ssu-Hung Wang ◽  
Yen-Liang Lai ◽  
Chin-Chuan Tsai ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
In Vivo Studies ◽  
Astragalus Membranaceus ◽  
Regeneration In Vitro

scholarly journals Enhanced osseointegration of dental implants with reduced graphene oxide coating

2022 ◽  
Author(s):  
Yong Cheol Shin ◽  
Ji-Hyeon Bae ◽  
Jong Ho Lee ◽  
Iruthayapandi Selestin Raja ◽  
Moon Sung Kang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Cell Attachment ◽  
Pure Titanium ◽  
Bone Morphogenetic Protein 2 ◽  
In Vivo Studies ◽  
Matrix Mineralization ◽  
Reduced Graphene

Abstract Background: The implants of pure titanium (Ti) and its alloys can lead to implant failure because of their poor interaction with bone-associated cells during bone regeneration. Surface modification over implants has achieved successful implants for enhanced osseointegration.Methods: Herein, we prepared sandblasted, large-grit, and acid-etched (SLA) Ti (ST) implants with different surface modifications [i.e., reduced graphene oxide (rGO) and recombinant human bone morphogenetic protein-2 (rhBMP-2)] and investigated their dental tissue regenerating ability in animal models. We performed comparative studies in surface property, in vitro cellular behaviors, and in vivo osseointegration activity among different groups, including ST (control), rhBMP-2-immobilized ST (BI-ST), rhBMP-2-treated ST (BT-ST), and rGO-coated ST (R-ST).Results: Spectroscopic, diffractometric, and microscopic analyses confirmed that rGO was coated well around the surfaces of Ti discs (for cell study) and implant fixtures (for animal study). Furthermore, in vitro and in vivo studies revealed that the R-ST group showed significantly better effects in cell attachment and proliferation, alkaline phosphatase activity, matrix mineralization, and osseointegration than the control (ST), BI-ST, and BT-ST groups.Conclusion: Hence, we suggest that the rGO-coated Ti can be a promising candidate for the application to dental or even orthopedic implants due to its ability to accelerate the healing rate with the high potential of osseointegration.

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