The electrostimulation and scar inhibition effect of chitosan/oxidized hydroxyethyl cellulose/reduced graphene oxide/asiaticoside liposome based hydrogel on peripheral nerve regeneration in vitro

2020 ◽  
Vol 109 ◽  
pp. 110560 ◽  
Author(s):  
Furong Zheng ◽  
Rui Li ◽  
Qundi He ◽  
Kelly Koral ◽  
Junyan Tao ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Reduced Graphene Oxide ◽  
Peripheral Nerve Regeneration ◽  
Hydroxyethyl Cellulose ◽  
Inhibition Effect ◽  
Reduced Graphene ◽  
Regeneration In Vitro

scholarly journals The influence of reduced graphene oxide on stem cells: a perspective in peripheral nerve regeneration

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Xiangyun Yao ◽  
Zhiwen Yan ◽  
Xu Wang ◽  
Huiquan Jiang ◽  
Yun Qian ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Graphene Oxide ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Reduced Graphene Oxide ◽  
Peripheral Nerve Regeneration ◽  
Embryonic Stem ◽  
Composite Scaffolds ◽  
Reduced Graphene

Abstract Graphene and its derivatives are fascinating materials for their extraordinary electrochemical and mechanical properties. In recent decades, many researchers explored their applications in tissue engineering and regenerative medicine. Reduced graphene oxide (rGO) possesses remarkable structural and functional resemblance to graphene, although some residual oxygen-containing groups and defects exist in the structure. Such structure holds great potential since the remnant-oxygenated groups can further be functionalized or modified. Moreover, oxygen-containing groups can improve the dispersion of rGO in organic or aqueous media. Therefore, it is preferable to utilize rGO in the production of composite materials. The rGO composite scaffolds provide favorable extracellular microenvironment and affect the cellular behavior of cultured cells in the peripheral nerve regeneration. On the one hand, rGO impacts on Schwann cells and neurons which are major components of peripheral nerves. On the other hand, rGO-incorporated composite scaffolds promote the neurogenic differentiation of several stem cells, including embryonic stem cells, mesenchymal stem cells, adipose-derived stem cells and neural stem cells. This review will briefly introduce the production and major properties of rGO, and its potential in modulating the cellular behaviors of specific stem cells. Finally, we present its emerging roles in the production of composite scaffolds for nerve tissue engineering.

Reduced graphene oxide–GelMA–PCL hybrid nanofibers for peripheral nerve regeneration

2020 ◽  
Vol 8 (46) ◽  
pp. 10593-10601
Author(s):  
Xingxing Fang ◽  
Haichang Guo ◽  
Wei Zhang ◽  
Haoming Fang ◽  
Qicheng Li ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Graphene Oxide ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Reduced Graphene Oxide ◽  
Peripheral Nerve Regeneration ◽  
Cell Behaviors ◽  
Hybrid Nanofibers ◽  
Reduced Graphene

Graphene oxide is currently used in peripheral nerve engineering but has certain limitations, such as cytotoxicity and lack of electrical conductivity, both of which are crucial in regulating nerve-associated cell behaviors.

Regulating Schwann Cells Growth by Chitosan Micropatterning for Peripheral Nerve Regeneration In Vitro

2014 ◽  
Vol 14 (8) ◽  
pp. 1067-1075 ◽  
Author(s):  
Guicai Li ◽  
Xueying Zhao ◽  
Luzhong Zhang ◽  
Caiping Wang ◽  
Yunwei Shi ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Peripheral Nerve Regeneration ◽  
Regeneration In Vitro
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