scholarly journals The Early Growth Response Gene Egr2 (Alias Krox20) Is a Novel Transcriptional Target of Transforming Growth Factor-β that Is Up-Regulated in Systemic Sclerosis and Mediates Profibrotic Responses

2011 ◽  
Vol 178 (5) ◽  
pp. 2077-2090 ◽  
Author(s):  
Feng Fang ◽  
Kohtaro Ooka ◽  
Swati Bhattachyya ◽  
Jun Wei ◽  
Minghua Wu ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Growth Factor ◽  
Growth Response ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Early Growth ◽  
Response Gene ◽  
Early Growth Response ◽  
Early Growth Response Gene ◽  
Transcriptional Target

scholarly journals Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β1–induced Pulmonary Fibrosis

2004 ◽  
Vol 200 (3) ◽  
pp. 377-389 ◽  
Author(s):  
Chun Geun Lee ◽  
Soo Jung Cho ◽  
Min Jong Kang ◽  
Svetlana P. Chapoval ◽  
Patty J. Lee ◽  
...  
Keyword(s):  
Growth Factor ◽  
Growth Response ◽  
Transforming Growth Factor ◽  
Early Growth ◽  
Transient Wave ◽  
Response Gene ◽  
Early Growth Response ◽  
Early Growth Response Gene ◽  
Tgf Β1

Fibrosis and apoptosis are juxtaposed in pulmonary disorders such as asthma and the interstitial diseases, and transforming growth factor (TGF)-β1 has been implicated in the pathogenesis of these responses. However, the in vivo effector functions of TGF-β1 in the lung and its roles in the pathogenesis of these responses are not completely understood. In addition, the relationships between apoptosis and other TGF-β1–induced responses have not been defined. To address these issues, we targeted bioactive TGF-β1 to the murine lung using a novel externally regulatable, triple transgenic system. TGF-β1 produced a transient wave of epithelial apoptosis that was followed by mononuclear-rich inflammation, tissue fibrosis, myofibroblast and myocyte hyperplasia, and septal rupture with honeycombing. Studies of these mice highlighted the reversibility of this fibrotic response. They also demonstrated that a null mutation of early growth response gene (Egr)-1 or caspase inhibition blocked TGF-β1–induced apoptosis. Interestingly, both interventions markedly ameliorated TGF-β1–induced fibrosis and alveolar remodeling. These studies illustrate the complex effects of TGF-β1 in vivo and define the critical role of Egr-1 in the TGF-β1 phenotype. They also demonstrate that Egr-1–mediated apoptosis is a prerequisite for TGF-β1–induced fibrosis and remodeling.

scholarly journals Increased Expression of the Transforming Growth Factor-β Signaling Pathway, Endoglin, and Early Growth Response-1 in Stable Plaques

Stroke ◽  
2009 ◽  
Vol 40 (2) ◽  
pp. 439-447 ◽  
Author(s):  
Pieter T.G. Bot ◽  
Imo E. Hoefer ◽  
Joost P.G. Sluijter ◽  
Patrick van Vliet ◽  
Anke M. Smits ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Growth Response ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Early Growth ◽  
Early Growth Response ◽  
Early Growth Response 1

scholarly journals Expression of NAG-1, a Transforming Growth Factor-β Superfamily Member, by Troglitazone Requires the Early Growth Response GeneEGR-1

2003 ◽  
Vol 279 (8) ◽  
pp. 6883-6892 ◽  
Author(s):  
Seung Joon Baek ◽  
Jong-Sik Kim ◽  
Jennifer B. Nixon ◽  
Richard P. DiAugustine ◽  
Thomas E. Eling
Keyword(s):  
Growth Factor ◽  
Growth Response ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Early Growth ◽  
Early Growth Response

scholarly journals Smad-Independent Transforming Growth Factor-β Regulation of Early Growth Response-1 and Sustained Expression in Fibrosis

2008 ◽  
Vol 173 (4) ◽  
pp. 1085-1099 ◽  
Author(s):  
Swati Bhattacharyya ◽  
Shu-Jen Chen ◽  
Minghua Wu ◽  
Matthew Warner-Blankenship ◽  
Hongyan Ning ◽  
...  
Keyword(s):  
Growth Factor ◽  
Growth Response ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Early Growth ◽  
Early Growth Response ◽  
Early Growth Response 1

scholarly journals Early Growth Response 3 (Egr-3) Is Induced by Transforming Growth Factor-β and Regulates Fibrogenic Responses

2013 ◽  
Vol 183 (4) ◽  
pp. 1197-1208 ◽  
Author(s):  
Feng Fang ◽  
Anna J. Shangguan ◽  
Kathleen Kelly ◽  
Jun Wei ◽  
Katherine Gruner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Growth Response ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Early Growth ◽  
Early Growth Response

scholarly journals HIV-1 Tat-Mediated Induction of Platelet-Derived Growth Factor in Astrocytes: Role of Early Growth Response Gene 1

2011 ◽  
Vol 186 (7) ◽  
pp. 4119-4129 ◽  
Author(s):  
Crystal Bethel-Brown ◽  
Honghong Yao ◽  
Shannon Callen ◽  
Young Han Lee ◽  
Prasanta K. Dash ◽  
...  
Keyword(s):  
Growth Factor ◽  
Growth Response ◽  
Early Growth ◽  
Platelet Derived Growth Factor ◽  
Response Gene ◽  
Early Growth Response ◽  
Early Growth Response Gene ◽  
Hiv 1
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