scholarly journals Tenascin-C Induces Phenotypic Changes in Fibroblasts to Myofibroblasts with High Contractility through the Integrin αvβ1/Transforming Growth Factor β/SMAD Signaling Axis in Human Breast Cancer

2020 ◽  
Vol 190 (10) ◽  
pp. 2123-2135 ◽  
Author(s):  
Daisuke Katoh ◽  
Yuji Kozuka ◽  
Aya Noro ◽  
Tomoko Ogawa ◽  
Kyoko Imanaka-Yoshida ◽  
...  
1989 ◽  
Vol 2 (2) ◽  
pp. 131-136 ◽  
Author(s):  
D. J. Kerr ◽  
I. B. Pragnell ◽  
A. Sproul ◽  
S. Cowan ◽  
T. Murray ◽  
...  

ABSTRACT There is some evidence to suggest that transforming growth factor-β (TGF-β) mediates the cytostatic effects of the anti-oestrogen tamoxifen. In this study we have demonstrated that α-interferon has a significant anti-proliferative effect on the oestrogen receptor-positive human breast cancer cell line ZR-75. There is decreased phenotypic expression of the oestrogen receptors (to about 30% of control values) and increased TGF-β mRNA. Under the growth conditions used here, ZR-75 cells had approximately 5800 TGF-β binding sites per cell, with an apparent dissociation constant of 70 pm, and we have shown that the anti-proliferative effects of α-interferon can be reduced by 60% by co-treating the cells with a TGF-β polyclonal antibody. The cytostatic effects of α-interferon may therefore be mediated by TGF-β in this human breast cancer cell line.


Cell ◽  
1987 ◽  
Vol 48 (3) ◽  
pp. 417-428 ◽  
Author(s):  
Cornelius Knabbe ◽  
Marc E. Lippman ◽  
Lalage M. Wakefield ◽  
Kathleen C. Flanders ◽  
Attan Kasid ◽  
...  

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