Short-term effects of endocrine-disrupting chemicals on the expression of estrogen-responsive genes in male medaka (Oryzias latipes)

2005 ◽  
Vol 72 (3) ◽  
pp. 239-249 ◽  
Author(s):  
Akemi Yamaguchi ◽  
Hiroshi Ishibashi ◽  
Shinya Kohra ◽  
Koji Arizono ◽  
Nobuaki Tominaga
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Oryzias Latipes ◽  
Short Term ◽  
Endocrine Disrupting ◽  
Short Term Effects

scholarly journals Short-Term Exposure Effects of Endocrine Disrupting Chemicals on the Brain-Pituitary-Gonadal Axis Response of the Fathead Minnow.

2009 ◽  
Vol 81 (Suppl_1) ◽  
pp. 263-263
Author(s):  
Edward F. Orlando ◽  
Jane Thompson ◽  
Marisol Sepulveda ◽  
Gary Ankley ◽  
Daniel Villeneuve ◽  
...  
Keyword(s):  
Fathead Minnow ◽  
Endocrine Disrupting Chemicals ◽  
Short Term ◽  
Short Term Exposure ◽  
Endocrine Disrupting ◽  
The Brain

Evaluation of reproductivity of medaka (Oryzias latipes) exposed to chemicals using a 2-week reproduction test

2000 ◽  
Vol 42 (7-8) ◽  
pp. 53-60 ◽  
Author(s):  
T. Shioda ◽  
M. Wakabayashi
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Oryzias Latipes ◽  
Test Method ◽  
Diethylhexyl Phthalate ◽  
Reproductive Ability ◽  
Tributyltin Chloride ◽  
Endocrine Disrupting ◽  
Reproduction Test ◽  
17Β Estradiol ◽  
Estrogenic Chemicals

Effects of endocrine disrupting chemicals on reproductive ability of medaka (Oryzias latipes) were investigated. Exposure of male medaka to estrogenic chemicals such as 17β-estradiol (E2), p-nonylphenol (NP), 4-t-butylphenol (BP) and bisphenol-A (BPA) caused a decrease in the numbers of eggs hatched rather than those of eggs spawned, which seemed to be affected by estrogen-like effects of these chemicals. Exposure of female medaka to E2 and NP reduced the numbers of eggs spawned rather than those of eggs hatched. The concentrations at which reproductivity of female decreased (E2:0.1 nmol/L, NP:0.03 μmu;mol/L) were lower than those of male (E2:3 nmol/L, NP:μ>0.3 μmu;mol/L). Diethylhexyl phthalate, benzophenone and tributyltin chloride did not affect reproductivity. In this study, adverse effects of estrogenic chemicals on reproductivity of medaka could be detected, so the materials and methods used in this study were considered to be able to be applied for a screening test method.

scholarly journals In vitro estrogenic, cytotoxic, and genotoxic profiles of the xenoestrogens 8-prenylnaringenine, genistein and tartrazine

2021 ◽  
Author(s):  
Atefeh Nasri ◽  
Raimo Pohjanvirta
Keyword(s):  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Micronucleus Assay ◽  
Environmental Estrogens ◽  
Short Term ◽  
Endocrine Disrupting ◽  
Health Promoting ◽  
Low Cytotoxicity ◽  
Mcf 7

AbstractPhytoestrogens have been widely praised for their health-promoting effects, whereas synthetic environmental estrogens are considered a toxicological risk to human health. The aim of this study was therefore to compare in vitro the estrogenic, cytotoxic, and genotoxic profiles of three common estrogen-like endocrine-disrupting chemicals: the phytoestrogens 8-prenylnaringenine (8-PN) and genistein and the synthetic xenoestrogen tartrazine. As assessed by a yeast bioreporter assay and estrogen-dependent proliferative response in human mammary gland adenocarcinoma cell line (MCF-7), 8-PN showed the highest estrogen-like activity of the three compounds, followed by tartrazine and genistein. After 24-h incubation on MCF-7 cells, all three compounds exhibited low cytotoxicity in the lactate dehydrogenase assay and no genotoxicity in the micronucleus assay. These results demonstrate that 8-PN, genistein and tartrazine possess variable estrogenic activity but display little cellular toxicity in short-term tests in vitro. No difference between phytoestrogens and a synthetic xenoestrogen could be established.

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