Induction of estrogen-responsive gene transcription in the embryo, larval, juvenile and adult life stages of zebrafish as biomarkers of short-term exposure to endocrine disrupting chemicals

2009 ◽  
Vol 150 (3) ◽  
pp. 414-420 ◽  
Author(s):  
Yuanxiang Jin ◽  
Rujia Chen ◽  
Liwei Sun ◽  
Haifeng Qian ◽  
Weiping Liu ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Endocrine Disrupting Chemicals ◽  
Adult Life ◽  
Life Stages ◽  
Short Term ◽  
Short Term Exposure ◽  
Endocrine Disrupting ◽  
Estrogen Responsive Gene ◽  
Responsive Gene

scholarly journals Short-Term Exposure Effects of Endocrine Disrupting Chemicals on the Brain-Pituitary-Gonadal Axis Response of the Fathead Minnow.

2009 ◽  
Vol 81 (Suppl_1) ◽  
pp. 263-263
Author(s):  
Edward F. Orlando ◽  
Jane Thompson ◽  
Marisol Sepulveda ◽  
Gary Ankley ◽  
Daniel Villeneuve ◽  
...  
Keyword(s):  
Fathead Minnow ◽  
Endocrine Disrupting Chemicals ◽  
Short Term ◽  
Short Term Exposure ◽  
Endocrine Disrupting ◽  
The Brain

Induction of hepatic estrogen-responsive gene transcription by permethrin enantiomers in male adult zebrafish

2008 ◽  
Vol 88 (2) ◽  
pp. 146-152 ◽  
Author(s):  
Yuanxiang Jin ◽  
Wanyuan Wang ◽  
Chao Xu ◽  
Zhengwei Fu ◽  
Weiping Liu
Keyword(s):  
Gene Transcription ◽  
Adult Zebrafish ◽  
Male Adult ◽  
Estrogen Responsive Gene ◽  
Responsive Gene

Short-term effects of endocrine-disrupting chemicals on the expression of estrogen-responsive genes in male medaka (Oryzias latipes)

2005 ◽  
Vol 72 (3) ◽  
pp. 239-249 ◽  
Author(s):  
Akemi Yamaguchi ◽  
Hiroshi Ishibashi ◽  
Shinya Kohra ◽  
Koji Arizono ◽  
Nobuaki Tominaga
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Oryzias Latipes ◽  
Short Term ◽  
Endocrine Disrupting ◽  
Short Term Effects

Short-term exposure of arsenite disrupted thyroid endocrine system and altered gene transcription in the HPT axis in zebrafish

2015 ◽  
Vol 205 ◽  
pp. 145-152 ◽  
Author(s):  
Hong-Jie Sun ◽  
Hong-Bo Li ◽  
Ping Xiang ◽  
Xiaowei Zhang ◽  
Lena Q. Ma
Keyword(s):  
Gene Transcription ◽  
Endocrine System ◽  
Short Term ◽  
Short Term Exposure ◽  
Altered Gene ◽  
Hpt Axis

Long-term failure of alveologenesis after an early short-term exposure to a PDGF-receptor antagonist

2011 ◽  
Vol 300 (4) ◽  
pp. L534-L547 ◽  
Author(s):  
Mandy Lau ◽  
Azhar Masood ◽  
Man Yi ◽  
Rosetta Belcastro ◽  
Jun Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Receptor Antagonist ◽  
Early Stage ◽  
Recovery Period ◽  
Adult Life ◽  
Pdgf Receptor ◽  
Short Term ◽  
Short Term Exposure ◽  
Alveolar Formation

Survivors of moderate-to-severe bronchopulmonary dysplasia have impaired alveologenesis lasting at least into early adult life. The mechanisms underlying this long-term effect are unknown. We hypothesized that short-term inhibition of growth factor-mediated early alveolar formation would result in a long-term impairment of subsequent alveologenesis. Neonatal rats were injected daily with the platelet-derived growth factor (PDGF) receptor antagonist, imatinib mesylate, from day 1– 7 of life, to inhibit the early alveolar formation occurring by in-growth of secondary crests into precursor saccules. The pups were then allowed to recover for 7, 14, 21, or 58 days. In imatinib-treated pups, DNA synthesis in total lung cells, and specifically in cells of secondary crests, was reduced at day 8 of life, had rebounded on day 14 of life but was then again reduced by day 28 of life. At day 8 of life, imatinib-treated pups had impaired alveologenesis as reflected by a decrease in secondary crests, an increase in alveolar size, and an overall decrease in both estimated alveolar number and generations compared with age-matched controls. No meaningful recovery was observed, even after a 21- or 58-day recovery period. The lungs of imatinib-treated pups had increased fibulin-5 content and an abnormal deposition of elastin. We conclude that reduced signaling through the PDGF pathways, at an early stage of alveologenesis, can result in long-lasting changes in lung architecture. A likely mechanism is through impaired formation of the elastin scaffold required for alveolarization.

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