Nitric oxide involvement and neural substrates of the conditioned and innate fear as evaluated in the T-maze test in rats

2008 ◽  
Vol 189 (2) ◽  
pp. 341-349 ◽  
Author(s):  
A.V. Calixto ◽  
F.S. Duarte ◽  
C.K.L. Moraes ◽  
M.S. Faria ◽  
T.C.M. De Lima
Keyword(s):  
Nitric Oxide ◽  
Neural Substrates ◽  
Maze Test ◽  
Innate Fear

scholarly journals The effect of L-arginine and its antagonist L-NAME and Methylene blue on sensory and cognitive function in mice

2012 ◽  
Vol 36 (1) ◽  
pp. 99-106
Author(s):  
Farid J. Al-Tahan
Keyword(s):  
Nitric Oxide ◽  
Methylene Blue ◽  
Functional Performance ◽  
Latency Period ◽  
The Novel ◽  
Male Mice ◽  
Control Groups ◽  
Novel Object ◽  
Female Mice ◽  
Maze Test

The present study was done to focus light on possible enhancement of the functional performance of male mice and female in neuronal behaviors by using L-arginine as a precursor of nitric oxide (NO). The results showed increase of latency period to reach the novel object in L-arginine treated groups and decrease in both L-NAME and methylene blue treated groups in both periods of treatment (15 and 30) days and were more prominent in male than in female mice as compared with control groups. Similar results were observed in passive avoidance latency period to enter the dark compartment. There was a reduction in latency period to reach the alternative arm of T-maze test in L-arginine treated groups and increase in both L-NAME and methylene blue treated groups in both periods of treatment (15 and 30) days in both genders. It could be concluded that L-arginine-NO pathway plays an important role in improving memory in male more than female mice.

scholarly journals The Study of the Effect of Sodium Nitroprusside in Anxiety-Like Behavior in Mice in Comparison With Diazepam

2020 ◽  
pp. 485-490
Author(s):  
Abeer Mudhafar Al-Humaidhi ◽  
Afrah Thiab Hlail ◽  
Semaa H. Shalal
Keyword(s):  
Nitric Oxide ◽  
Sodium Nitroprusside ◽  
Elevated Plus Maze ◽  
Research Attention ◽  
Anxiolytic Drug ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Nitric Oxide Pathway ◽  
Light Dark Box

Anxiety has become a highly paramount field of research attention in psychopharmacology today. Sundry studies have shown a nitric oxide role in the regulation of anxiety. The goal of the study was to investigate sodium nitroprusside ability to affect anxiety-like behavior in mice and to compare this effect with the standard anxiolytic drug, diazepam, using both plus maze test and light/dark box test. The results revealed that sodium nitroprusside at a dose of 1 mg/kg had a significant effect on the behavior in both of the elevated plus maze test and light/dark test. However, at higher dose (3 mg/kg), it has significantly increased the anxiogenic-like effect in the light/dark box test. Diazepam at a dose of 2 mg/kg increased the time spent in open arms in elevated plus maze test and that in light chambers of light/dark test. These outcomes suggest that a nitric oxide pathway seems to play an important role in anxiety. Furthermore, sodium nitroprusside at a dose of 1 mg/kg showed a nearly anxiolytic ability, when compared with diazepam.

Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test

1997 ◽  
Vol 323 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Moacir S Faria ◽  
Marcelo N Muscará ◽  
Heitor Moreno ◽  
Simone A Teixeira ◽  
Heidi B Dias ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthesis ◽  
Maze Test ◽  
Plus Maze

Nitric oxide involvement in estrous cycle-dependent changes of the behavioral responses of female rats in the elevated plus-maze test

2007 ◽  
Vol 178 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Hamid Reza Sadeghipour ◽  
Mehdi Ghasemi ◽  
Hamed Sadeghipour ◽  
Kiarash Riazi ◽  
Mohammad Soufiabadi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Estrous Cycle ◽  
Elevated Plus Maze ◽  
Behavioral Responses ◽  
Female Rats ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Cycle Dependent
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