scholarly journals Corticotropin releasing hormone receptor 2 antagonist, RQ-00490721, for the prevention of pressure overload-induced cardiac dysfunction

2022 ◽  
Vol 146 ◽  
pp. 112566
Author(s):  
Yu Mori ◽  
Ayako Tsuchihira ◽  
Tatsuya Yoshida ◽  
Satoya Yoshida ◽  
Akiyoshi Fujiuchi ◽  
...  
Keyword(s):  
Cardiac Dysfunction ◽  
Hormone Receptor ◽  
Pressure Overload ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

scholarly journals Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction

2017 ◽  
Vol 214 (7) ◽  
pp. 1877-1888 ◽  
Author(s):  
Takuma Tsuda ◽  
Mikito Takefuji ◽  
Nina Wettschureck ◽  
Kazuhiko Kotani ◽  
Ryota Morimoto ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cardiac Dysfunction ◽  
Hormone Receptor ◽  
Adenosine Monophosphate ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Corticotropin Releasing Hormone ◽  
Ventricular Ejection Fraction ◽  
Releasing Hormone

Heart failure occurs when the heart is unable to effectively pump blood and maintain tissue perfusion. Despite numerous therapeutic advancements over previous decades, the prognosis of patients with chronic heart failure remains poor, emphasizing the need to identify additional pathophysiological factors. Here, we show that corticotropin releasing hormone receptor 2 (Crhr2) is a G protein–coupled receptor highly expressed in cardiomyocytes and continuous infusion of the Crhr2 agonist, urocortin 2 (Ucn2), reduced left ventricular ejection fraction in mice. Moreover, plasma Ucn2 levels were 7.5-fold higher in patients with heart failure compared to those in healthy controls. Additionally, cardiomyocyte-specific deletion of Crhr2 protected mice from pressure overload-induced cardiac dysfunction. Mice treated with a Crhr2 antagonist lost maladaptive 3′-5′-cyclic adenosine monophosphate (cAMP)–dependent signaling and did not develop heart failure in response to overload. Collectively, our results indicate that constitutive Crhr2 activation causes cardiac dysfunction and suggests that Crhr2 blockade is a promising therapeutic strategy for patients with chronic heart failure.

Dissecting the role of Corticotropin-releasing hormone receptor type 1 in Alzheimer's Disease

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
K Lerche ◽  
M Willem ◽  
K Kleinknecht ◽  
C Romberg ◽  
U Konietzko ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hormone Receptor ◽  
Receptor Type ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

scholarly journals CORTICOTROPIN RELEASING HORMONE RECEPTOR 2 (CRHR-2) GENE IS ASSOCIATED WITH DECREASED RISK AND SEVERITY OF POSTTRAUMATIC STRESS DISORDER IN WOMEN

2013 ◽  
Vol 30 (12) ◽  
pp. 1161-1169 ◽  
Author(s):  
Erika J. Wolf ◽  
Karen S. Mitchell ◽  
Mark W. Logue ◽  
Clinton T. Baldwin ◽  
Annemarie F. Reardon ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Hormone Receptor ◽  
Stress Disorder ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Neuromedin U-induced anorexigenic action is mediated by the corticotropin-releasing hormone receptor-signaling pathway in goldfish

Peptides ◽  
2009 ◽  
Vol 30 (12) ◽  
pp. 2483-2486 ◽  
Author(s):  
Keisuke Maruyama ◽  
Kohei Wada ◽  
Kotaro Ishiguro ◽  
Sei-Ichi Shimakura ◽  
Tatsuya Wakasugi ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Hormone Receptor ◽  
Receptor Signaling ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Receptor Signaling Pathway

Mapping of the mouse corticotropin-releasing hormone receptor 2 gene (Crhr2) to Chromosome 6

1997 ◽  
Vol 8 (12) ◽  
pp. 944-945 ◽  
Author(s):  
J. Shonee Lesh ◽  
Heather L. Burrows ◽  
Audrey F. Seasholtz ◽  
Sally A. Camper
Keyword(s):  
Hormone Receptor ◽  
Chromosome 6 ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

scholarly journals Physiological Roles of Corticotropin-Releasing Hormone Receptor Type 2.

2001 ◽  
Vol 48 (1) ◽  
pp. 1-9 ◽  
Author(s):  
KOZO HASHIMOTO ◽  
SHINYA MAKINO ◽  
KOICHI ASABA ◽  
MITSURU NISHIYAMA
Keyword(s):  
Hormone Receptor ◽  
Receptor Type ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone
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