Long-term studies on the integration of acellular porcine dermis as an implant shell and the effect on capsular fibrosis around silicone implants in a rat model

2019 ◽  
Vol 72 (9) ◽  
pp. 1555-1563 ◽  
Author(s):  
I. Ludolph ◽  
J.S. Gruener ◽  
A. Kengelbach-Weigand ◽  
C. Fiessler ◽  
R.E. Horch ◽  
...  
Keyword(s):  
Rat Model ◽  
Silicone Implants ◽  
Porcine Dermis ◽  
Capsular Fibrosis ◽  
Long Term Studies

Abstract P770: An Mri-Based Method for Assessing the Extent and Location of Bleeding in a Rat Model of Subarachnoid Hemorrhage

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Mitchell Butler ◽  
Joseph R Geraghty ◽  
Deepshika Sudhakar ◽  
Tyler Lung ◽  
Fernando Testai ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Subarachnoid Hemorrhage ◽  
Rat Model ◽  
Alternative Methods ◽  
Slice Thickness ◽  
Brain Extraction ◽  
Spin Echo Sequence ◽  
Long Term Studies

Objective: Studies in subarachnoid hemorrhage (SAH) animal models are limited to early timepoints, after which the brain is extracted to confirm hemorrhage. For long-term studies, blood is resorbed by the time of euthanasia and thus alternative methods of confirming SAH are necessary. Here, we used in vivo MRI to determine the presence, extent, and location of blood in the endovascular perforation rat model of SAH. Methods: Animals were divided into two groups - SAH and sham controls (no perforation). Rats were imaged at 24 hours in a 9.4T MRI scanner. T2-weighted imaging (T2WI) was used to quantify and localize the volume and extension of blood. T2WI was performed with a fast spin echo sequence with TR/TE = 5000/60 ms, FOV = 40x40 mm 2 , 0.75 mm slice thickness, and no interslice gap. SAH was identified as hypointense signal at the skull base, a normally hyperintense region due to cerebrospinal fluid in the basal cisterns. Regions of interest were identified and segmented manually. Pixels were converted to areas, and the total hypointense volume (V hypo ) was computed by summing all areas. V hypo was normalized to total brain volume (TBV) for each animal. Ability to detect blood via MRI was compared to the gold standard of direct visualization of blood after brain extraction using receiver operating characteristic (ROC) curves. The location of blood was plotted along a standardized antero-posterior axis. 3D reconstructions were developed in 3D Slicer to visualize the spatial distribution of hemorrhage. Results: V hypo values were 1.6±1.4 mm 3 sham (n = 8) and 7.5±3.9 mm 3 for SAH (n = 10) [p=0.0003]. This difference persisted when V hypo was normalized to TBV (p=0.0005). There was no difference in the TBV between groups (p=0.1493). V hypo distinguished between SAH and sham animals (p=0.001, area under curve = 0.963). A cutoff of V hypo = 4.63 mm 3 corresponded to 100% specificity and 80% sensitivity for confirming SAH. The spatial distribution of bleeding varied along the antero-posterior axis within the subarachnoid space. Conclusions: We developed an in vivo MRI method for the quantification of SAH blood volume and location in rats. This will be used for future long-term studies to confirm and grade severity of SAH.

Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants

2016 ◽  
Vol 41 (1) ◽  
pp. 211-220 ◽  
Author(s):  
Sebastian Fischer ◽  
Yannick Diehm ◽  
Thomas Henzler ◽  
Martin R. Berger ◽  
Jonas Kolbenschlag ◽  
...  
Keyword(s):  
Silicone Implants ◽  
Long Term Effects ◽  
Clostridium Histolyticum ◽  
Capsular Fibrosis

Implications of Long-Term Studies of Three Model Preschool Programs for Head Start

2008 ◽  
Author(s):  
Lawrence J. Schweinhart ◽  
Elena V. Malofeeva ◽  
Lawrence J. Schweinhart ◽  
Michelle M. Englund ◽  
Arthur J. Reynolds ◽  
...  
Keyword(s):  
Head Start ◽  
Preschool Programs ◽  
Long Term Studies

Rat model of long term effects after fractionated (2Gy/day) 60Gy irradiation of rat liver

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
F Moriconi ◽  
IA Malik ◽  
A Amanzada ◽  
G Ramadori ◽  
CF Hess
Keyword(s):  
Rat Liver ◽  
Rat Model ◽  
Long Term Effects

Rat model of fractionated (2 Gy/day) 60 Gy irradiation of the liver: long-term effects

2013 ◽  
Vol 51 (08) ◽  
Author(s):  
M Rave-Fränk ◽  
I Malik ◽  
H Christiansen ◽  
S Sultan ◽  
N Naz ◽  
...  
Keyword(s):  
Rat Model ◽  
Long Term Effects

Primary varicose veins

Phlebologie ◽  
2010 ◽  
Vol 39 (03) ◽  
pp. 133-137
Author(s):  
H. Partsch
Keyword(s):  
Varicose Veins ◽  
Compression Therapy ◽  
Daily Practice ◽  
Clinical Severity ◽  
Compression Stockings ◽  
Primary Varicose Veins ◽  
The Cost ◽  
Convincing Data ◽  
Long Term Studies

SummaryBackground: Compression stockings are widely used in patients with varicose veins. Methods: Based on published literature three main points are discussed: 1. the rationale of compression therapy in primary varicose veins, 2. the prescription of compression stockings in daily practice, 3. studies required in the future. Results: The main objective of prescribing compression stockings for patients with varicose veins is to improve subjective leg complaints and to prevent swelling after sitting and standing. No convincing data are available concerning prevention of progression or of complications. In daily practice varicose veins are the most common indication to prescribe compression stockings. The compliance depends on the severity of the disorder and is rather poor in less severe stages. Long-term studies are needed to proof the cost-effectiveness of compression stockings concerning subjective symptoms and objective signs of varicose veins adjusted to their clinical severity. Conclusion: Compression stockings in primary varicose veins are able to improve leg complaints and to prevent swelling.

Diatoms and aquatic palynomorphs in the sediments of the Eurasian Arctic seas and their significance for paleooceanological investigations in the Arctic

2019 ◽  
pp. 246-251
Author(s):  
Yelena I. Polyakova ◽  
Yekaterina I. Novichkova ◽  
Tatiana S. Klyuvitkina ◽  
Elizaveta A. Agafonova ◽  
Irina M. Kryukova
Keyword(s):  
Bering Sea ◽  
Surface Sediments ◽  
Sea Water ◽  
The Arctic ◽  
Marginal Filter ◽  
Arctic Seas ◽  
Hydrological Parameters ◽  
The Arctic Ocean ◽  
Long Term Studies

Presented the results of long-term studies of diatoms and aquatic palynomorphs in surface sediments of the Arctic seas and the possibility of their use for the reconstructions of paleocirculation water masses, advection of Atlantic and Bering sea water into the Arctic ocean, changes in the river runoff to the seas, sedimentary processes in the marginal filter of the largest rivers, seasonal sea ice cover and other hydrological parameters.

Aspects of the Evolution of the Romanian Tourists’ Preferences Concerning the Domestic Tourist Destinations

2019 ◽  
Vol 10 (1) ◽  
pp. 21-28
Author(s):  
Aniela Bălăcescu ◽  
Radu Șerban Zaharia
Keyword(s):  
Logistic Model ◽  
Local Level ◽  
Medium Term ◽  
Tourist Destinations ◽  
Tourism Management ◽  
Production And Consumption ◽  
On Line ◽  
The One ◽  
Long Term Studies

Abstract Tourist services represent a category of services in which the inseparability of production and consumption, the inability to be storable, the immateriality, and last but not least non-durability, induces in tourism management a number of peculiarities and difficulties. Under these circumstances the development of medium-term strategies involves long-term studies regarding on the one hand the developments and characteristics of the demand, and on the other hand the tourist potential analysis at regional and local level. Although in the past 20 years there has been tremendous growth of on-line booking made by household users, the tour operators agencies as well as those with sales activity continue to offer the specific services for a large number of tourists, that number, in the case of domestic tourism, increased by 1.6 times in case of the tour operators and by 4.44 times in case of the agencies with sales activity. At the same time, there have been changes in the preferences of tourists regarding their holiday destinations in Romania. Started on these considerations, paper based on a logistic model, examines the evolution of the probabilities and scores corresponding to the way the Romanian tourists spend their holidays on the types of tourism agencies, actions and tourist areas in Romania.

Planning a system of permanent sample plots for integrated long-term studies of community-based forest management

1970 ◽  
Vol 16 (2) ◽  
pp. 3-11 ◽  
Author(s):  
H Meilby ◽  
L Puri ◽  
M Christensen ◽  
S Rayamajhi
Keyword(s):  
Forest Management ◽  
Key Words ◽  
Research Note ◽  
Managed Forests ◽  
Community Based ◽  
Permanent Sample Plots ◽  
Long Term Studies

To monitor the development of four community-managed forests, networks of permanent sample plots were established in 2005 at sites in Chitwan, Kaski and Mustang Districts, Nepal. This research note documents the procedures used when preparing for establishment of the plot networks, evaluates the applied stratification of the forest on the basis of data gathered in pilot surveys conducted in the early 2005, and provides a discussion on the implications of the choices made. Key words: Community-managed forests; permanent sample plots; stratification; allocation; estimates Banko Janakari Vol.16(2) 2006 pp.3-11

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