Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active Factor Xa inhibitors

2008 ◽  
Vol 16 (6) ◽  
pp. 3125-3140 ◽  
Author(s):  
Yasuhiro Imaeda ◽  
Tetsuji Kawamoto ◽  
Mamoru Tobisu ◽  
Noriko Konishi ◽  
Katsuhiko Hiroe ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Active Factor ◽  
Orally Active

Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors

2008 ◽  
Vol 16 (5) ◽  
pp. 2243-2260 ◽  
Author(s):  
Yasuhiro Imaeda ◽  
Toshio Miyawaki ◽  
Hiroki Sakamoto ◽  
Fumio Itoh ◽  
Noriko Konishi ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Active Factor ◽  
New Class ◽  
Orally Active

Orally active factor Xa inhibitors: 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine derivatives

2004 ◽  
Vol 14 (11) ◽  
pp. 2935-2939 ◽  
Author(s):  
Noriyasu Haginoya ◽  
Syozo Kobayashi ◽  
Satoshi Komoriya ◽  
Yumiko Hirokawa ◽  
Taketoshi Furugori ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Pyridine Derivatives ◽  
Active Factor ◽  
Orally Active

Orally Active Factor Xa Inhibitors: 4,5,6,7-Tetrahydrothiazolo[5,4-c]pyridine Derivatives.

ChemInform ◽  
2004 ◽  
Vol 35 (38) ◽  
Author(s):  
Noriyasu Haginoya ◽  
Syozo Kobayashi ◽  
Satoshi Komoriya ◽  
Yumiko Hirokawa ◽  
Taketoshi Furugori ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Pyridine Derivatives ◽  
Active Factor ◽  
Orally Active

Orally active factor Xa inhibitors: Investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy

2008 ◽  
Vol 18 (16) ◽  
pp. 4682-4687 ◽  
Author(s):  
Masahiko Uchida ◽  
Kosuke Okazaki ◽  
Harunobu Mukaiyama ◽  
Hidetoshi Isawa ◽  
Hiroaki Kobayashi ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Active Factor ◽  
Orally Active

Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

2009 ◽  
Vol 17 (6) ◽  
pp. 2501-2511 ◽  
Author(s):  
Chad A. Van Huis ◽  
Agustin Casimiro-Garcia ◽  
Christopher F. Bigge ◽  
Wayne L. Cody ◽  
Danette A. Dudley ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Duration Of Action ◽  
Active Factor ◽  
Extended Duration ◽  
Orally Active

Discovery of Imidazo[1,5-c]imidazol-3-ones: Weakly Basic, Orally Active Factor Xa Inhibitors

2008 ◽  
Vol 51 (12) ◽  
pp. 3422-3436 ◽  
Author(s):  
Yasuhiro Imaeda ◽  
Takanobu Kuroita ◽  
Hiroki Sakamoto ◽  
Tetsuji Kawamoto ◽  
Mamoru Tobisu ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Active Factor ◽  
Orally Active

Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives

2004 ◽  
Vol 12 (20) ◽  
pp. 5415-5426 ◽  
Author(s):  
Hiroyuki Koshio ◽  
Fukushi Hirayama ◽  
Tsukasa Ishihara ◽  
Hiroyuki Kaizawa ◽  
Takeshi Shigenaga ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitor ◽  
Active Factor ◽  
Orally Active

Orally active zwitterionic factor Xa inhibitors with long duration of action

2011 ◽  
Vol 21 (24) ◽  
pp. 7337-7343 ◽  
Author(s):  
Akiyoshi Mochizuki ◽  
Tsutomu Nagata ◽  
Hideyuki Kanno ◽  
Daisuke Takano ◽  
Masamichi Kishida ◽  
...  
Keyword(s):  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Duration Of Action ◽  
Long Duration ◽  
Orally Active
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