The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.06.029 ◽

2012 ◽

Vol 22 (15) ◽

pp. 4979-4985 ◽

Author(s):

Moon H. Kim ◽

Amy Lew Tsuhako ◽

Erick W. Co ◽

Dana T. Aftab ◽

Frauke Bentzien ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.04.019 ◽

2008 ◽

Vol 16 (10) ◽

pp. 5514-5528 ◽

Author(s):

Aleem Gangjee ◽

Ojas A. Namjoshi ◽

Jianming Yu ◽

Michael A. Ihnat ◽

Jessica E. Thorpe ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Antiangiogenic Agents ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Multiple Receptor ◽

Receptor Tyrosine Kinase Inhibitors

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Design, synthesis, and biological evaluation of novel 3-pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives as potent receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.08.037 ◽

2013 ◽

Vol 23 (20) ◽

pp. 5630-5633 ◽

Author(s):

Lei Ding ◽

Feng Tang ◽

Wei Huang ◽

Qiu Jin ◽

Han Shen ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.03.021 ◽

2008 ◽

Vol 18 (8) ◽

pp. 2691-2695 ◽

Author(s):

Vijaya Gracias ◽

Zhiqin Ji ◽

Irini Akritopoulou-Zanze ◽

Cele Abad-Zapatero ◽

Jeffrey R. Huth ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(98)00070-4 ◽

1998 ◽

Vol 6 (8) ◽

pp. 1153-1162 ◽

Author(s):

Klaus Hinterding ◽

Axel Knebel ◽

Peter Herrlich ◽

Herbert Waldmann

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

New Class ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.03.031 ◽

2007 ◽

Vol 17 (11) ◽

pp. 3136-3140 ◽

Author(s):

Irini Akritopoulou-Zanze ◽

Daniel H. Albert ◽

Peter F. Bousquet ◽

George A. Cunha ◽

Christopher M. Harris ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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WITHDRAWN: Design, synthesis and biological evaluation of 3-substituted-4-anilinequinoline as EGFR tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.10.030 ◽

2012 ◽

Author(s):

Yongjun Mao ◽

Kai Xie ◽

Wenxiu Zhu ◽

Jianfeng Li ◽

Hua Xie ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.03.053 ◽

2013 ◽

Vol 21 (11) ◽

pp. 3090-3104 ◽

Author(s):

Yongjun Mao ◽

Wenxiu Zhu ◽

Xiaoguang Kong ◽

Zhen Wang ◽

Hua Xie ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of the Quinazoline Derivatives as L858R/T790M/C797S Triple Mutant Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.c20-00411 ◽

2020 ◽

Vol 68 (10) ◽

pp. 971-980

Author(s):

Mingguang Zhang ◽

Yunyun Wang ◽

Jia Wang ◽

Zhaogang Liu ◽

Jingmiao Shi ◽

...

Keyword(s):

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Biological Evaluation ◽

Triple Mutant ◽

Design Synthesis ◽

Epidermal Growth ◽

Quinazoline Derivatives ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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Design, synthesis, screening, and molecular modeling study of a new series of ROS1 receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.08.029 ◽

2009 ◽

Vol 19 (19) ◽

pp. 5622-5626 ◽

Author(s):

Ibrahim M. El-Deeb ◽

Byung Sun Park ◽

Su Jin Jung ◽

Kyung Ho Yoo ◽

Chang-Hyun Oh ◽

...

Keyword(s):

Molecular Modeling ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Design Synthesis ◽

Molecular Modeling Study ◽

Receptor Tyrosine Kinase Inhibitors ◽

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N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: Design, synthesis, and in vivo evaluation

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.01.029 ◽

2012 ◽

Vol 20 (7) ◽

pp. 2444-2454 ◽

Author(s):

Aleem Gangjee ◽

Nilesh Zaware ◽

Sudhir Raghavan ◽

Jie Yang ◽

Jessica E. Thorpe ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

In Vivo Evaluation ◽

Design Synthesis ◽

Multiple Receptor ◽

Receptor Tyrosine Kinase Inhibitors

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