An Untapped Resource: Characteristics of Thrombus Recovered from Intermediate or High Risk Pulmonary Embolus Patients

2021 ◽  
pp. 107392
Author(s):  
Geoffrey Newcomb ◽  
Bennett L. Wilson ◽  
R. James White ◽  
Bruce Goldman ◽  
Neil A. Lachant ◽  
...  
2010 ◽  
Vol 19 ◽  
pp. S219-S220
Author(s):  
S. Gomes ◽  
M. Yang ◽  
B. Chan ◽  
S. Roy
Keyword(s):  

2012 ◽  
Vol 1 (2) ◽  
Author(s):  
Jonathan S. Taylor ◽  
Rodney H. Breau ◽  
Ilias Cagiannos ◽  
Christopher Morash

Renal sarcoma with venous tumour thrombus is usually an aggressive malignancy that necessitates complete surgical extirpation to achieve cure. Due to the rarity of these tumours, clinicians rely on case reports to better understandand treat patients with this disease. We recently encountered 2 patientswith renal sarcoma who developed malignant pulmonary embolus. Our cases,combined with those previously published, suggest renal sarcoma tumour thrombusis at high risk for spontaneous and intraoperative embolization. This reportdetails our experience and outlines measures that may decrease the rate ofvenous tumour embolization in patients with sarcoma.


Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4066-4066
Author(s):  
Colleen Donck ◽  
Jin Huh ◽  
Jack Seki ◽  
Eric Chen ◽  
Erik Yeo

Abstract Contemporary evidence suggests thromboprophylaxis in medical oncology patients may be effective, however, according to global surveys, is greatly underutilized despite the substantial risk of venous thromboembolism (VTE). To date, routine thromboprophylaxis of medical oncology inpatients has not been evaluated at a cancer care institution. Not equally common in all types of cancer, VTE is thought to present a higher risk in selected solid tumours of the CNS, lung, gastrointestinal and genitourinary tracts. Recommendations from the Sixth ACCP Consensus Conference on Antithrombotic Therapy include implementing institution-specific VTE prophylaxis guidelines for high-risk patients. The objectives of this study are to develop and implement targeted VTE prophylaxis guidelines for high-risk solid tumour inpatients during admission to a medical oncology ward and to evaluate the impact on prescribing practice. The study is a prospective, observational, before and after chart review with retrospective validation. VTE prophylaxis guidelines were developed through literature review and expert consensus. The results presented are the baseline pre-phase data over 14 weeks. Of nearly 240 charts assessed for eligibility criteria, 92 (39%) were stratified as high-risk according to the developed guidelines based on tumour site. Seventy-two of those patients identified as high-risk were followed prospectively to determine the baseline rates of thromboprophylaxis and venographically confirmed symptomatic VTE. Retrospective validation of results was performed in all 237 patients. Current results of the pre-phase revealed appropriate VTE prophylaxis with a low-molecular weight heparin based on the proposed guidelines in three eligible patients (5.3%). A total of 13 eligible patients (19%) received any form of pharmacological or non-pharmacological prophylaxis. The rate of symptomatic VTE was 11% (n = 10) among high-risk patients of which five patients developed pulmonary embolus (PE), four patients presented with deep vein thrombosis (DVT) and one patient developed portal vein thrombosis. Among non high-risk patients, the rate of symptomatic VTE was significantly lower at 3% (n = 5), among which three patients presented with PE and two patients developed DVT. In both groups, pulmonary embolus was the most common manifestation of VTE. No clinically significant bleeding occurred during prophylaxis. The rate of symptomatic VTE among the highly selected at-risk medical oncology population at this institution was substantially different than the non high-risk population and is in accordance with the literature. This study presents new data on the rates of symptomatic VTE and thromboprophylaxis for medical oncology patients in a hospital setting. The rate of VTE prophylaxis of 5.3% seen in the pre-phase appears unacceptably low given that appropriate pharmacological intervention may potentially reduce the VTE rate by as much as 50% as suggested by relevant literature. As such, implementation of VTE prophylaxis guidelines at this cancer care center is ongoing.


1982 ◽  
Vol 47 (4) ◽  
pp. 373-375 ◽  
Author(s):  
James L. Fitch ◽  
Thomas F. Williams ◽  
Josephine E. Etienne

The critical need to identify children with hearing loss and provide treatment at the earliest possible age has become increasingly apparent in recent years (Northern & Downs, 1978). Reduction of the auditory signal during the critical language-learning period can severely limit the child's potential for developing a complete, effective communication system. Identification and treatment of children having handicapping conditions at an early age has gained impetus through the Handicapped Children's Early Education Program (HCEEP) projects funded by the Bureau of Education for the Handicapped (BEH).


1983 ◽  
Vol 48 (1) ◽  
pp. 110-110

For the November 1982 JSHD article, "A Community Based High Risk Register for Hearing Loss," the author would like to acknowledge three additional individuals who made valuable contributions to the study. They are Marie Carrier, Gene Lyon, and Bobbie Robertson.


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