mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

Marina K. Holz; Bryan A. Ballif; Steven P. Gygi; John Blenis

doi:10.1016/j.cell.2021.03.060

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

Cell ◽

10.1016/j.cell.2021.03.060 ◽

2021 ◽

Vol 184 (8) ◽

pp. 2255

Author(s):

Marina K. Holz ◽

Bryan A. Ballif ◽

Steven P. Gygi ◽

John Blenis

Keyword(s):

Preinitiation Complex

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Faculty Opinions recommendation of Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717968103.793467784 ◽

2012 ◽

Author(s):

Tony Weil

Keyword(s):

Preinitiation Complex ◽

Complex Assembly ◽

Pol Ii ◽

And Function

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Transcription initiated by RNA polymerase II and purified transcription factors from liver. Transcription factors alpha, beta gamma, and delta promote formation of intermediates in assembly of the functional preinitiation complex.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)39150-1 ◽

1990 ◽

Vol 265 (13) ◽

pp. 7559-7563 ◽

Cited By ~ 3

Author(s):

R C Conaway ◽

J W Conaway

Keyword(s):

Transcription Factors ◽

Rna Polymerase ◽

Rna Polymerase Ii ◽

Preinitiation Complex ◽

Alpha Beta

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Genome-Wide Organization of Eukaryotic Preinitiation Complex Is Influenced by Nonconsensus Protein-DNA Binding

Biophysical Journal ◽

10.1016/j.bpj.2013.01.038 ◽

2013 ◽

Vol 104 (5) ◽

pp. 1107-1115 ◽

Cited By ~ 19

Author(s):

Ariel Afek ◽

David B. Lukatsky

Keyword(s):

Dna Binding ◽

Preinitiation Complex ◽

Genome Wide

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Potential targets for HSF1 within the preinitiation complex

Cell Stress and Chaperones ◽

10.1379/1466-1268(2000)005<0229:ptfhwt>2.0.co;2 ◽

2000 ◽

Vol 5 (3) ◽

pp. 229 ◽

Cited By ~ 24

Author(s):

Chao-Xing Yuan ◽

William B Gurley

Keyword(s):

Preinitiation Complex

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Faculty Opinions recommendation of Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735802305.793571138 ◽

2020 ◽

Author(s):

Xiaolin Cheng

Keyword(s):

Genetic Diseases ◽

Complex Structure ◽

Preinitiation Complex ◽

Structure And Dynamics ◽

Insight Into

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The major transcriptional transactivation domain of simian virus 40 large T antigen associates nonconcurrently with multiple components of the transcriptional preinitiation complex.

Journal of Virology ◽

10.1128/jvi.70.2.1191-1202.1996 ◽

1996 ◽

Vol 70 (2) ◽

pp. 1191-1202 ◽

Cited By ~ 35

Author(s):

S D Johnston ◽

X M Yu ◽

J E Mertz

Keyword(s):

Simian Virus 40 ◽

Simian Virus ◽

T Antigen ◽

Transactivation Domain ◽

Large T Antigen ◽

Preinitiation Complex ◽

Multiple Components ◽

Transcriptional Transactivation

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Coordinated movement of eukaryotic translation initiation factors 1, 1A, and 5 within the 43S ribosomal preinitiation complex (PIC) mediates the response to start codon recognition.

The FASEB Journal ◽

10.1096/fasebj.26.1_supplement.550.2 ◽

2012 ◽

Vol 26 (S1) ◽

Author(s):

Jagpreet Singh Nanda ◽

Antonio Munoz ◽

Adesh K Saini ◽

Alan G Hinnebusch

Keyword(s):

Translation Initiation ◽

Start Codon ◽

Preinitiation Complex ◽

Eukaryotic Translation ◽

Initiation Factors ◽

Codon Recognition ◽

Translation Initiation Factors ◽

Eukaryotic Translation Initiation ◽

Eukaryotic Translation Initiation Factors

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Mapping the Location of TFIIB within the RNA Polymerase II Transcription Preinitiation Complex

Cell ◽

10.1016/j.cell.2004.09.028 ◽

2004 ◽

Vol 119 (2) ◽

pp. 169-180 ◽

Cited By ~ 106

Author(s):

Hung-Ta Chen ◽

Steven Hahn

Keyword(s):

Rna Polymerase ◽

Rna Polymerase Ii ◽

Preinitiation Complex ◽

Rna Polymerase Ii Transcription

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Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex

Cell ◽

10.1016/0092-8674(88)90118-3 ◽

1988 ◽

Vol 54 (7) ◽

pp. 1033-1042 ◽

Cited By ~ 228

Author(s):

Masami Horikoshi ◽

Tsonwin Hai ◽

Young-Sun Lin ◽

Michael R. Green ◽

Robert G. Roeder

Keyword(s):

Transcription Factor ◽

Preinitiation Complex

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Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture

Genes & Development ◽

10.1101/gad.285775.116 ◽

2016 ◽

Vol 30 (18) ◽

pp. 2119-2132 ◽

Cited By ~ 21

Author(s):

Thomas Eychenne ◽

Elizaveta Novikova ◽

Marie-Bénédicte Barrault ◽

Olivier Alibert ◽

Claire Boschiero ◽

...

Keyword(s):

Preinitiation Complex ◽

Complex Assembly ◽

Promoter Architecture

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