scholarly journals SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans

Cell ◽  
2021 ◽  
Author(s):  
Philip A. Mudd ◽  
Anastasia A. Minervina ◽  
Mikhail V. Pogorelyy ◽  
Jackson S. Turner ◽  
Wooseob Kim ◽  
...  
Keyword(s):  
Cell Response ◽  
Helper Cell ◽  
Follicular Helper ◽  
T Follicular Helper Cell

scholarly journals IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans

Blood ◽  
2013 ◽  
Vol 121 (17) ◽  
pp. 3375-3385 ◽  
Author(s):  
Nathalie Schmitt ◽  
Jacinta Bustamante ◽  
Laure Bourdery ◽  
Salah Eddine Bentebibel ◽  
Stephanie Boisson-Dupuis ◽  
...  
Keyword(s):  
B Cells ◽  
Cell Response ◽  
Memory B Cells ◽  
Helper Cell ◽  
Tfh Cells ◽  
Control Subjects ◽  
Follicular Helper ◽  
Key Points ◽  
T Follicular Helper Cell

Key Points IL-12Rβ1–deficient subjects displayed substantially less circulating memory Tfh and memory B cells than control subjects. The IL-12–STAT4 axis is associated with the development and functions of Tfh cells in vivo in humans.

Sustained T follicular helper cell response is essential for control of chronic viral infection

2017 ◽  
Vol 2 (18) ◽  
pp. eaam8686 ◽  
Author(s):  
Ute Greczmiel ◽  
Nike Julia Kräutler ◽  
Alessandro Pedrioli ◽  
Ilka Bartsch ◽  
Paola Agnellini ◽  
...  
Keyword(s):  
Viral Infection ◽  
Cell Response ◽  
Helper Cell ◽  
Chronic Viral Infection ◽  
Follicular Helper ◽  
T Follicular Helper Cell

scholarly journals Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Marisa Stebegg ◽  
Alexandre Bignon ◽  
Danika Lea Hill ◽  
Alyssa Silva-Cayetano ◽  
Christel Krueger ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Response ◽  
Plasma Cells ◽  
Cell Formation ◽  
Helper Cell ◽  
Older Individuals ◽  
Aged Mice ◽  
Vaccine Responses ◽  
Follicular Helper ◽  
T Follicular Helper Cell

Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent infection. With advancing age the GC and Tfh cell response declines, resulting in impaired humoral immunity. We sought to discover what underpins the poor Tfh cell response in ageing and whether it is possible to correct it. Here, we demonstrate that older people and aged mice have impaired Tfh cell differentiation upon vaccination. This deficit is preceded by poor activation of conventional dendritic cells type 2 (cDC2) due to reduced type 1 interferon signalling. Importantly, the Tfh and cDC2 cell response can be boosted in aged mice by treatment with a TLR7 agonist. This demonstrates that age-associated defects in the cDC2 and Tfh cell response are not irreversible and can be enhanced to improve vaccine responses in older individuals.

scholarly journals TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection

Cell Reports ◽  
2015 ◽  
Vol 12 (12) ◽  
pp. 2099-2110 ◽  
Author(s):  
Tuoqi Wu ◽  
Hyun Mu Shin ◽  
E. Ashley Moseman ◽  
Yun Ji ◽  
Bonnie Huang ◽  
...  
Keyword(s):  
Viral Infection ◽  
Cell Response ◽  
Helper Cell ◽  
Follicular Helper ◽  
T Follicular Helper Cell
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