Gas chromatography/mass spectrometry versus liquid chromatography/fluorescence detection in the analysis of phenols in mainstream cigarette smoke

2007 ◽  
Vol 1141 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Serban C. Moldoveanu ◽  
Melissa Kiser
1998 ◽  
Vol 81 (6) ◽  
pp. 1252-1256 ◽  
Author(s):  
Yoshie Yamazaki ◽  
Takahiro Ninomiya

Abstract A simple and rapid method was developed for determining bitertanol residues in strawberries. Bitertanol was extracted from samples with ethyl acetate. Bitertanol acetate was added prior to extraction as a surrogate standard. The ethyl acetate extract was cleaned up by passing through tandem solid-phase extraction columns consisting of anion-exchange (SAX) and aminopropyl (NH2) bonded silica. The eluate was evaporated to dryness and reconstituted with methanol. Bitertanol residues were determined by liquid chromatography with fluorescence detection. Recoveries at 4 fortified levels (0.05,0.25,0.5, and 1.0 (µg/g), calculated by the internal standard method, ranged from 92.1 to 99.1 %, with coefficients of variation ranging from 0.3 to 4.0%. The detection limit was 0.01 µg/g. Of 25 commercial strawberry samples analyzed for bitertanol residues, 5 contained bitertanol residues at concentrations ranging from 0.02 to 0.51 µg/g. Positive samples were confirmed by gas chromatography/mass spectrometry with mass-selective detection (m/z 170 and 168).


2020 ◽  
Vol 16 (8) ◽  
pp. 989-1019
Author(s):  
Habibur Rahman ◽  
S.K. Manirul Haque ◽  
Masoom Raza Siddiqui

Background: Schizophrenia is a severe mental illness that affects more than twenty-one million people throughout the world. Schizophrenia also causes early death. Schizophrenia and other related psychotic ailments are controlled by the prescription of antipsychotic drugs, which act by blocking certain chemical receptors in the brain and thus relieves the symptoms of psychotic disorder. These drugs are present in the different dosage forms in the market and provided in a certain amount as per the need of the patients. Objective: Since such medications treat mental disorders, it is very important to have a perfect and accurate dose so that the risk factor is not affected by a higher or lower dose, which is not sufficient for the treatment. For accurate assay of these kinds of drugs, different analytical methods were developed ranging from older spectrophotometric techniques to latest hyphenated methods. Results: The current review highlights the role of different analytical techniques that were employed in the determination and identification of antipsychotic drugs and their metabolites. Techniques such as spectrophotometry, fluorimetry, liquid chromatography, liquid chromatography-mass spectrometry, gas chromatography, and gas chromatography-mass spectrometry employed in the method development of such antipsychotic drugs were reported in the review. Different metabolites, identified using the hyphenated techniques, were also mentioned in the review. The synthesis pathways of few of the metabolites were mentioned. Conclusion: The review summarizes the analyses of different antipsychotic drugs and their metabolites. A brief introduction of illnesses and their symptoms and possible medications were highlighted. Synthesis pathways of the associated metabolites were also mentioned.


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