The role of hyaluronic acid in SEB-induced acute lung inflammation

2013 ◽  
Vol 146 (1) ◽  
pp. 56-69 ◽  
Author(s):  
Olga N. Uchakina ◽  
Clara M. Castillejo ◽  
Christy C. Bridges ◽  
Robert J. McKallip
Keyword(s):  
Hyaluronic Acid ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

scholarly journals The Role of Hyaluronic Acid in SEB‐Induced Acute Lung Inflammation

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Clara Miluska Castillejo ◽  
Olga Uchakina ◽  
Christy Bridges ◽  
Robert McKallip
Keyword(s):  
Hyaluronic Acid ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

scholarly journals Induction of acute lung inflammation in mice with hemorrhagic shock and resuscitation: role of HMGB1

2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Raymond LC Kao ◽  
Xuemei Xu ◽  
Anargyros Xenocostas ◽  
Neil Parry ◽  
Tina Mele ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

scholarly journals Role of CD14 in a Mouse Model of Acute Lung Inflammation Induced by Different Lipopolysaccharide Chemotypes

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10183 ◽  
Author(s):  
Adam A. Anas ◽  
Joppe W. R. Hovius ◽  
Cornelis van 't Veer ◽  
Tom van der Poll ◽  
Alex F. de Vos
Keyword(s):  
Mouse Model ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

scholarly journals Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement

2013 ◽  
Vol 110 (13) ◽  
pp. 5205-5210 ◽  
Author(s):  
T. Murata ◽  
K. Aritake ◽  
Y. Tsubosaka ◽  
T. Maruyama ◽  
T. Nakagawa ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Signal Enhancement ◽  
Acute Lung Inflammation ◽  
Therapeutic Application ◽  
Anti Inflammatory

A crucial role of nitric oxide in acute lung injury secondary to the acute necrotizing pancreatitis

2010 ◽  
Vol 29 (4) ◽  
pp. 329-337 ◽  
Author(s):  
Shi Cheng ◽  
Wen-Mao Yan ◽  
Bin Yang ◽  
Jing-dong Shi ◽  
Mao-min Song ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Injury ◽  
Lung Inflammation ◽  
Necrotizing Pancreatitis ◽  
Acute Necrotizing Pancreatitis ◽  
No Production ◽  
Acute Lung Inflammation ◽  
Tnf Α ◽  
Acute Necrotizing

To investigate the role of nitric oxide (NO) in acute lung inflammation and injury secondary to acute necrotizing pancreatitis (ANP), 5% sodium taurocholate was retrogradely injected into the biliopancreatic duct of rats to ANP model. These ANP rats were given L-Arginine (L-Arg, 100 mg/kg), L-NAME (10 mg/kg), or their combination by intraperitoneal injection 30 min prior to ANP induction. At 1, 3, 6, and 12 hours after ANP induction, lung NO production, and inducible NO synthase (iNOS) expression were measured. Lung histopathological changes, bronchoalveolar lavage (BAL) protein concentration, proinflammatory mediators tumor necrotic factor alpha (TNF-α), and lung tissue myeloperoxidase (MPO) activity were examined. Results showed that NO production and iNOS mRNA expression in alveolar macrophages (AMs) were significantly increased along with significant increases in lung histological abnormalities and BAL proteins in the ANP group, all of which were further enhanced by pretreatment with L-Arg and attenuated by pretreatment with L-NAME, respectively. These markers were slightly attenuated by pretreatment with combination of L-Arg + L-NAME, suggesting that NO is required for initiating the acute lung damage in ANP rats, and also that L-Arg-enhanced lung injury is mediated by its NO generation rather than its direct effect. MPO activity and TNF-α expression in lung were upregulated in the ANP rats and further enhanced by pretreatment with L-Arg and attenuated by pretreatment with L-NAME, respectively. These results suggest that overproduction of NO mediated by iNOS in the lung is required for the acute lung inflammation and damage secondary to ANP.

scholarly journals ACUTE LUNG INFLAMMATION INDUCED BY LIPOPOLYSACCHARIDE: ROLE OF INSULIN

Shock ◽  
2003 ◽  
Vol 19 (Supplement) ◽  
pp. 66
Author(s):  
T. C Alba ◽  
R. Curi ◽  
P. Sannomiya
Keyword(s):  
Lung Inflammation ◽  
Acute Lung Inflammation
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