Soil conditioning is a key factor in increasing tunnel face stability and extraction efficiency of excavated soil when excavating tunnels using an earth pressure balance (EPB) shield tunnel boring machine (TBM). Weathered granite soil, which is abundant in the Korean Peninsula (also in Japan, Hong Kong, and Singapore), has different characteristics than sand and clay; it also has particle-crushing characteristics. Conditioning agents were mixed with weathered granite soils of different individual particle-size gradations, and three characteristics (workability, permeability, and compressibility) were evaluated to find an optimal conditioning method. The lower and upper bounds of the water content that are needed for a well-functioning EPB shield TBM were also proposed. Through a trial-and-error experimental analysis, it was confirmed that soil conditioning using foam only was possible when the water content was controlled within the allowable range, that is, between the upper and lower bounds; when water content exceeded the upper bound, soil conditioning with solidification agents was needed along with foam. By taking advantage of the particle-crushing characteristics of the weathered granite soil, it was feasible to adopt the EPB shield TBM even when the soil was extremely coarse and cohesionless by conditioning with polymer slurries along with foam. Finally, the application ranges of EPB shield TBM in weathered granite soil were proposed; the newly proposed ranges are wider and expanded to coarser zones compared with those proposed so far.