scholarly journals Connectomic features underlying diverse synaptic connection strengths and subcellular computation

2021 ◽  
Author(s):  
Tony X. Liu ◽  
Pasha A. Davoudian ◽  
Kristyn M. Lizbinski ◽  
James M. Jeanne
Keyword(s):  
Synaptic Connection

scholarly journals THE NEUROBIOLOGY OF THE ECTONEURAL/HYPONEURAL SYNAPTIC CONNECTION IN AN ECHINODERM

1985 ◽  
Vol 168 (3) ◽  
pp. 432-446 ◽  
Author(s):  
JAMES L. S. COBB
Keyword(s):  
Synaptic Connection

scholarly journals Costs and benefits of using rhythmic rate codes

2021 ◽  
Author(s):  
Erik J. Peterson ◽  
Bradley Voytek
Keyword(s):  
Nervous System ◽  
Population Size ◽  
Synaptic Connection ◽  
Poisson Model ◽  
Neural Oscillations ◽  
Costs And Benefits ◽  
Rate Code ◽  
Firing Rates ◽  
Alternative Approach ◽  
Connection Type

AbstractNeural oscillations are one of the most well-known macroscopic phenomena observed in the nervous system, and the benefits of oscillatory coding have been the topic of frequent analysis. Many of these studies focused on communication between populations which were already oscillating, and sought to understand how synchrony and communication interact. In this paper, take an alternative approach. We focus on measuring the costs, and benefits, of moving to an from an aperiodic code to a rhythmic one. We utilize a Linear-Nonlinear Poisson model, and assume a rate code. We report that no one factor seems to predict the costs, or benefits, of translating into a rhythmic code. Instead the synaptic connection type, strength, population size, and stimulus and oscillation firing rates interact in nonlinear ways. We suggest a number of experiments that might be used to confirm these predictions.Author summaryIt’s good to oscillate, sometimes.

scholarly journals Functional GABAergic Synaptic Connection in Neonatal Mouse Barrel Cortex

1996 ◽  
Vol 16 (15) ◽  
pp. 4684-4695 ◽  
Author(s):  
Ariel Agmon ◽  
Greg Hollrigel ◽  
Diane K. O’Dowd
Keyword(s):  
Barrel Cortex ◽  
Synaptic Connection ◽  
Neonatal Mouse

Two Neuropeptides Colocalized in a Command-Like Neuron Use Distinct Mechanisms to Enhance Its Fast Synaptic Connection

2003 ◽  
Vol 90 (3) ◽  
pp. 2074-2079 ◽  
Author(s):  
H.-Y. Koh ◽  
F. S. Vilim ◽  
J. Jing ◽  
K. R. Weiss
Keyword(s):  
High Frequency ◽  
Synaptic Connection ◽  
Quantal Content ◽  
Functional Consequence ◽  
Functional Implication ◽  
Quantal Size ◽  
Quantal Analysis ◽  
Cholinergic Interneuron ◽  
Single Synapse ◽  
Stimulation Of

In many neurons more than one peptide is colocalized with a classical neurotransmitter. The functional consequence of such an arrangement has been rarely investigated. Here, within the feeding circuit of Aplysia, we investigate at a single synapse the actions of two modulatory neuropeptides that are present in a cholinergic interneuron. In combination with previous work, our study shows that the command-like neuron for feeding, CBI-2, contains two neuropeptides, feeding circuit activating peptide (FCAP) and cerebral peptide 2 (CP2). Previous studies showed that high-frequency prestimulation or repeated stimulation of CBI-2 increases the size of CBI-2 to B61/62 excitatory postsynaptic potentials (EPSPs) and shortens the latency of firing of neuron B61/62 in response to CBI-2 stimulation. We find that both FCAP and CP2 mimic these two effects. The variance method of quantal analysis indicates that FCAP increases the calculated quantal size ( q) and CP2 increases the calculated quantal content ( m) of EPSPs. Since the PSP amplitude represents the product of q and m, the joint action of the two peptides is expected to be cooperative. This observation suggests a possible functional implication for multiple neuropeptides colocalized with a classical neurotransmitter in one neuron.

Identification of a putative mechanosensory neuron in Lymnaea: characterization of its synaptic and functional connections with the whole-body withdrawal interneuron

1996 ◽  
Vol 76 (5) ◽  
pp. 3230-3238 ◽  
Author(s):  
T. Inoue ◽  
M. Takasaki ◽  
K. Lukowiak ◽  
N. I. Syed
Keyword(s):  
Sensory Neuron ◽  
Action Potentials ◽  
Synaptic Connection ◽  
Lucifer Yellow ◽  
Whole Body ◽  
Pond Snail ◽  
Mechanosensory Neuron ◽  
Functional Connections ◽  
Freshwater Pond ◽  
Withdrawal Behavior

1. In this study, we identified a putative mechanosensory neuron in the freshwater pond snail Lymnaea stagnalis. This sensory neuron, termed right parietal dorsal 3 (RPD3), mediates part of the whole-body withdrawal behavior via the activation of a withdrawal interneuron. 2. RPD3 is located in the central ring ganglia, where its soma is situated on the dorsal surface of the right parietal ganglion. Intracellular injection of the dye Lucifer yellow revealed that RPD3 has both central and peripheral axonal projections. 3. In isolated-CNS preparations, RPD3 was quiescent. In semi-intact preparations, however, a gentle/moderate mechanical touch (by a pair of blunt forceps) to the mantle cavity or columellar musculature elicited action potentials in RPD3 in the absence of prepotential activity. Furthermore, mechanical stimulus-induced action potentials in RPD3 persisted in the presence of zero Ca2+/ high Mg2+ and high Ca2+/high Mg2+ salines. Together, these data suggest that RPD3 is most likely to be a primary sensory neuron. 4. In both isolated-CNS and semi-intact preparations, intracellular depolarization of RPD3 excited the whole-body withdrawal interneuron right pedal dorsal 11 (RPeD11). This synaptic connection persisted in the presence of high Ca2+ and high Mg2+ saline, suggesting that it is likely to be monosynaptic. Moreover, when stimulated electrically, the interneuron RPeD11 induced an hyperpolarizing response in RPD3. The possibility of this connection being monosynaptic was not tested, however, in the present study. Together, these data demonstrate that RPD3 excites RPeD11, which in turn may inhibit RPD3 activity. 5. In the semi-intact preparation, a mechanical touch to the mantle edge excited RPD3, which in turn generated action potentials in RPeD11. Zero Ca2+ saline blocked this synaptic connection between RPD3 and RPeD11, suggesting that it is chemical. 6. To demonstrate that RPD3 was sufficient to induce the withdrawal response and that the withdrawal behavior was mediated indirectly via RPeD11, we made simultaneous intracellular recordings from these two neurons while monitoring muscle contractions via a tension transducer. Intracellular depolarization of RPD3 elicited action potentials in RPeD11, followed by the contraction of the columellar muscle. Similar stimulation of RPD3 failed to excite a simultaneously hyperpolarized RPeD11 and as a result, no contraction of the columellar muscle occurred. Direct intracellular depolarization of RPeD11, however, induced the contraction of the columellar muscle. These data suggest that RPD3-induced withdrawal behavior is mediated in part via RPeD11.

scholarly journals Network Self-Organization Explains the Statistics and Dynamics of Synaptic Connection Strengths in Cortex

2013 ◽  
Vol 9 (1) ◽  
pp. e1002848 ◽  
Author(s):  
Pengsheng Zheng ◽  
Christos Dimitrakakis ◽  
Jochen Triesch
Keyword(s):  
Synaptic Connection ◽  
Self Organization
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