Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug–drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys

2015 ◽  
Vol 30 (2) ◽  
pp. 198-204 ◽  
Author(s):  
Masaki Watanabe ◽  
Takao Watanabe ◽  
Masashi Yabuki ◽  
Ikumi Tamai
Keyword(s):  
Drug Interaction ◽  
Organic Anion ◽  
Dehydroepiandrosterone Sulfate ◽  
Cynomolgus Monkeys ◽  
Organic Anion Transporting Polypeptide ◽  
Drug Drug Interaction

Molecular localization and characterization of multiple binding sites of organic anion transporting polypeptide 2B1 (OATP2B1) as the mechanism for substrate and modulator dependent drug–drug interaction

MedChemComm ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 1775-1782 ◽  
Author(s):  
Yusuke Hoshino ◽  
Daichi Fujita ◽  
Takeo Nakanishi ◽  
Ikumi Tamai
Keyword(s):  
Drug Interaction ◽  
Binding Sites ◽  
Organic Anion ◽  
Schematic Model ◽  
Organic Anion Transporting Polypeptide ◽  
Multiple Binding Sites ◽  
Multiple Binding ◽  
Drug Drug Interaction ◽  
The Relationship

Schematic model of the relationship and locations of putative binding sites of substrates and modulators in OATP2B1. Drug–drug interaction and drug–food interaction on OATP2B1 can be predicted by clarification of multiple binding sites.

scholarly journals Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

2020 ◽  
Vol 15 (2) ◽  
pp. 252-263 ◽  
Author(s):  
Yanna Zhu ◽  
Xiaokui Huo ◽  
Changyuan Wang ◽  
Qiang Meng ◽  
Zhihao Liu ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Organic Anion ◽  
Organic Anion Transporters ◽  
Anion Transporters ◽  
Drug Drug Interaction

Pitavastatin as an In Vivo Probe for Studying Hepatic Organic Anion Transporting Polypeptide-Mediated Drug–Drug Interactions in Cynomolgus Monkeys

2013 ◽  
Vol 41 (10) ◽  
pp. 1875-1882 ◽  
Author(s):  
Tsuyoshi Takahashi ◽  
Tatsuyuki Ohtsuka ◽  
Takahiro Yoshikawa ◽  
Ichiro Tatekawa ◽  
Yasuhiro Uno ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Organic Anion ◽  
Cynomolgus Monkeys ◽  
Organic Anion Transporting Polypeptide

Renal Organic Anion Transporter-Mediated Drug-Drug Interaction between Gemcabene and Quinapril

2009 ◽  
Vol 330 (1) ◽  
pp. 191-197 ◽  
Author(s):  
Haodan Yuan ◽  
Bo Feng ◽  
Ying Yu ◽  
Jonathan Chupka ◽  
Jenny Y. Zheng ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Anion Transporter ◽  
Drug Drug Interaction
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