scholarly journals Corrigendum to

2022 ◽  
Vol 230 ◽  
pp. 114107
Author(s):  
Xin Deng ◽  
Qianqian Qiu ◽  
Baowei Yang ◽  
Xuekun Wang ◽  
Wenlong Huang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Medicinal Chemistry ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of novel fungicides for the management of Fusarium DieBack disease

2019 ◽  
Vol 62 (3) ◽  
Author(s):  
Israel Bonilla Landa ◽  
Osvaldo León De la Cruz ◽  
Diana Sánchez Rangel ◽  
Randy Ortiz Castro ◽  
Benjamin Rodriguez Haas ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antifungal Activity ◽  
Fusarium Solani ◽  
Antifungal Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Dieback Disease ◽  
Synthetic Chemist ◽  
Fusarium Dieback ◽  
Synthesis And Biological Evaluation

Abstract. Fusarium Dieback, a new and lethal insect-vectored disease can host over 300 tree species including the avocado trees. This problem has recently attracted the attention of synthetic chemist not only to develop new triazol antifungal agents but also due to severe drug resistance to “classic” triazol antifungal agents. Here, a series of novel antifungal triazoles with a p-trifluoromethylphenyl moiety were synthesized and characterized by spectroscopic and spectrometric methods. Most of the target compounds synthesized showed from modest to good inhibitory activity and less phytotoxicity in comparison with the commercially available propiconazol; in particular, compounds 7 and 13 were active against both Fusarium solani and Fusarium euwallaceae. The results showed that compounds 7, 13, and 4 have great potential to be developed as new antifungal agents because of both good antifungal activity and low phytotoxicity. SAR showed that free alcohols and not O-protected compounds significantly influence the activity. Hence, a-methyl-a-1,2,4-triazole emerged as novel compound to develop new ketone-triazole-type antifungal agents for the management of Fusarium Dieback disease Resumen. Fusarium Dieback es una nueva enfermedad letal transmitida por insectos que actúan como vectores y puede atacar a más de 300 especies de árboles, incluidos los árboles de aguacate. Recientemente, este problema ha atraído la atención de los químicos sintéticos para desarrollar nuevos agentes antifúngicos triazólicos debido a la resistencia severa que desarrollan los insectos a los agentes antifúngicos triazólicos "clásicos". Durante este trabajo, se sintetizaron nuevos triazoles antifúngicos que contienen un grupo p-trifluorometilfenilo y se caracterizaron por métodos espectroscópicos y espectrométricos. La mayoría de los compuestos diana sintetizados mostraron una actividad inhibidora de modesta a buena y menos fitotoxicidad en comparación con el propiconazol que es comercialmente disponible; en particular, los compuestos 7 y 13 mostraron ser activos contra Fusarium solani y Fusarium euwallaceae. Los resultados mostraron que los compuestos 7, 13 y 4 tienen un gran potencial para desarrollarse como nuevos agentes antifúngicos debido a la buena actividad antifúngica y su baja fitotoxicidad. SAR mostró que los alcoholes libres y no los compuestos O-protegidos influyen significativamente en la actividad. Por lo tanto, el α-metil-α-1,2,4-triazol surgió como un nuevo compuesto líder para desarrollar nuevos agentes antifúngicos tipo cetona-triazol para el tratamiento de la enfermedad Fusarium Dieback.

Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents

2012 ◽  
Vol 22 (23) ◽  
pp. 7268-7271 ◽  
Author(s):  
Tianwen Li ◽  
Yongchong Yang ◽  
Changmei Cheng ◽  
Amit K. Tiwari ◽  
Kamlesh Sodani ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents

2018 ◽  
Vol 26 (4) ◽  
pp. 884-890 ◽  
Author(s):  
Cornelis P. Vlaar ◽  
Linette Castillo-Pichardo ◽  
Julia I. Medina ◽  
Cathyria M. Marrero-Serra ◽  
Ericka Vélez ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Carbazole Derivatives ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation

scholarly journals Design, Synthesis and Biological Evaluation of Novel Rapamycin Benzothiazole Hybrids as mTOR Targeted Anti-cancer Agents

2016 ◽  
Vol 64 (4) ◽  
pp. 346-355 ◽  
Author(s):  
Lijun Xie ◽  
Jie Huang ◽  
Xiaoming Chen ◽  
Hui Yu ◽  
Kualiang Li ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation

Erratum to Design, Synthesis and Biological Evaluation of a Phenyl Butyric Acid Derivative, N-(4-chlorophenyl)-4- phenylbutanamide: A HDAC6 Inhibitor with Anti-proliferative Activity on Cervix Cancer and Leukemia Cells

2018 ◽  
Vol 18 (8) ◽  
pp. 1218-1218
Keyword(s):  
Acid Derivative ◽  
Butyric Acid ◽  
Proliferative Activity ◽  
Biological Evaluation ◽  
Cervix Cancer ◽  
Leukemia Cells ◽  
Design Synthesis ◽  
Anti Cancer ◽  
Hdac6 Inhibitor ◽  
Synthesis And Biological Evaluation

Due to an oversight one of the author’s name was published wrong in the article entitled “Design, Synthesis and Biological Evaluation of a Phenyl Butyric Acid Derivative, N-(4-chlorophenyl)-4- phenylbutanamide: A HDAC6 Inhibitor with Anti-proliferative Activity on Cervix Cancer and Leukemia Cells” in “Anti-Cancer Agents in Medicinal Chemistry, 2017, Vol. 17, No. 10. pp. 1441.” The correct names of all authors are given below: Rodríguez-Fonseca RA, Sixto-López Y, Fragoso-Vázquez MJ, Flores-Mejía R, Cabrera-Pérez LC, Vázquez-Moctezuma I, Rosales-Hernández MC, Bello M, Martínez-Archundia M, Trujillo-Ferrara JG, Becerra-Martínez E, Correa-Basurto J.

Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

2014 ◽  
Vol 12 (21) ◽  
pp. 3446-3458 ◽  
Author(s):  
Hai-Xia Jiang ◽  
Dao-Min Zhuang ◽  
Ying Huang ◽  
Xing-Xin Cao ◽  
Jian-Hua Yao ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Resistance Profile ◽  
Drug Resistance Profile ◽  
Synthesis And Biological Evaluation ◽  
Anti Hiv ◽  
Hiv 1

A novel series of trifluoromethyl indoles have been designed, synthesized and evaluated for anti-HIV-1 activities.

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