A study to establish gestation-specific reference intervals for thyroid function tests in normal singleton pregnancy

2008 ◽  
Vol 137 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Christina Cotzias ◽  
Sarah-Jane Wong ◽  
Erica Taylor ◽  
Paul Seed ◽  
Joanna Girling
Keyword(s):  
Thyroid Function ◽  
Reference Intervals ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Singleton Pregnancy ◽  
Function Tests

Gestation specific reference intervals for thyroid function tests in pregnancy

2016 ◽  
Vol 54 (8) ◽  
Author(s):  
Süleyman Akarsu ◽  
Filiz Akbiyik ◽  
Eda Karaismailoglu ◽  
Zeliha Gunnur Dikmen
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
First Trimester ◽  
Reference Intervals ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Second Trimester ◽  
Third Trimester ◽  
The Third ◽  
Function Tests

AbstractThyroid function tests are frequently assessed during pregnancy to evaluate thyroid dysfunction or to monitor pre-existing thyroid disease. However, using non-pregnant reference intervals can lead to misclassification. International guidelines recommended that institutions should calculate their own pregnancy-specific reference intervals for free thyroxine (FT4), free triiodothyronine (FT3) and thyroid-stimulating hormone (TSH). The objective of this study is to establish gestation-specific reference intervals (GRIs) for thyroid function tests in pregnant Turkish women and to compare these with the age-matched non-pregnant women.Serum samples were collected from 220 non-pregnant women (age: 18–48), and 2460 pregnant women (age: 18–45) with 945 (39%) in the first trimester, 1120 (45%) in the second trimester, and 395 (16%) in the third trimester. TSH, FT4 and FT3 were measured using the Abbott Architect i2000SR analyzer.GRIs of TSH, FT4 and FT3 for first trimester pregnancies were 0.49–2.33 mIU/L, 10.30–18.11 pmol/L and 3.80–5.81 pmol/L, respectively. GRIs for second trimester pregnancies were 0.51–3.44 mIU/L, 10.30–18.15 pmol/L and 3.69–5.90 pmol/L. GRIs for third trimester pregnancies were 0.58–4.31 mIU/L, 10.30–17.89 pmol/L and 3.67–5.81 pmol/L. GRIs for TSH, FT4 and FT3 were different from non-pregnant normal reference intervals.TSH levels showed an increasing trend from the first trimester to the third trimester, whereas both FT4 and FT3 levels were uniform throughout gestation. GRIs may help in the diagnosis and appropriate management of thyroid dysfunction during pregnancy which will prevent both maternal and fetal complications.

Trimester-specific reference intervals of thyroid function tests in Turkish pregnants

2019 ◽  
Vol 36 (5) ◽  
pp. 413-416
Author(s):  
Oktay Bulur ◽  
Zeliha Atak ◽  
Derun Taner Ertugrul ◽  
Esin Beyan ◽  
Emre Gunakan ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Reference Intervals ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Function Tests

First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population

2020 ◽  
Author(s):  
Dustin R Bunch ◽  
Kyle Firmender ◽  
Roa Harb ◽  
Joe M El-Khoury
Keyword(s):  
Thyroid Function ◽  
The United States ◽  
Reference Intervals ◽  
Adverse Outcomes ◽  
Specific Reference ◽  
Thyroid Peroxidase ◽  
Thyroid Function Tests ◽  
Second Trimester ◽  
Function Tests ◽  
Increased Risk

Abstract Objectives Thyroid dysfunction in pregnancy is associated with increased risk of adverse outcomes to mother and child. Trimester-specific reference intervals for thyroid function tests are not routinely provided by clinical laboratories. In this study, we present first- and second-trimester-specific reference intervals in a US population for thyroid-stimulating hormone (TSH), free thyroxine (FT4), total thyroxine (T4), and total triiodothyronine (T3) measured on Roche analyzers. Methods We used patient samples from first- and second-trimester prenatal screening. Samples were limited to singleton pregnancies and negative screening results for thyroid peroxidase and thyroglobulin antibodies. Analytes (TSH, FT4, T4, and T3) were measured on a Roche Modular e170 then verified on a Roche cobas e801. Results The reference intervals established on the e170 and verified on the e801 for the first trimester were 0.11 to 3.48 mIU/L for TSH, 11.2 to 19.0 pmol/L for FT4, 51.1 to 185.6 nmol/L for T4, and 1.4 to 3.5 nmol/L for T3. The reference intervals for the second trimester were 0.31 to 3.85 mIU/L for TSH, 9.4 to 16.5 pmol/L for FT4, 55.1 to 174.0 nmol/L for T4, and 1.5 to 3.7 nmol/L for T3. Conclusions This is the first report of trimester-specific reference intervals for thyroid function tests on Roche analyzers in the United States, and it is consistent with worldwide reports.

A Practical Approach for the Verification and Determination of Site- and Trimester-Specific Reference Intervals for Thyroid Function Tests in Pregnancy

Thyroid ◽  
2019 ◽  
Vol 29 (3) ◽  
pp. 412-420 ◽  
Author(s):  
Lois E. Donovan ◽  
Amy Metcalfe ◽  
Alex Chin ◽  
Jennifer M. Yamamoto ◽  
Heidi Virtanen ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Reference Intervals ◽  
Practical Approach ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Function Tests ◽  
In Pregnancy

scholarly journals Trimester-Specific Reference Ranges for Thyroid Hormones in Iranian Pregnant Women

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ladan Mehran ◽  
Atieh Amouzegar ◽  
Hossein Delshad ◽  
Sahar Askari ◽  
Mehdi Hedayati ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Pregnant Women ◽  
Thyroid Function ◽  
Final Analysis ◽  
Reference Intervals ◽  
Specific Reference ◽  
Reference Ranges ◽  
Thyroid Function Tests ◽  
Thyroid Disorder ◽  
Function Tests

Background. Due to many physiological changes during pregnancy, interpretation of thyroid function tests needs trimester-specific reference intervals for a specific population. There is no normative data documented for thyroid hormones on healthy pregnant women in Iran. The present survey was conducted to determine trimester-specific reference ranges for serum TSH, thyroxine (TT4), and triiodothyronine (TT3).Methods. The serum of 215 cases was analyzed for measurement of thyroid function tests by immunoassay method of which 152 iodine-sufficient pregnant women without thyroid autoantibodies and history of thyroid disorder or goiter were selected for final analysis. Reference intervals were defined as 5th and 95th percentiles.Results. Reference intervals in the first, second, and third trimesters were as follows: TSH (0.2–3.9, 0.5–4.1, and 0.6–4.1 mIU/l), TT4 (8.2–18.5, 10.1–20.6, and 9–19.4 μg/dl), and TT3 (137.8–278.3, 154.8–327.6, and 137–323.6 ng/dl), respectively. No correlation was found between TSH and TT4 or TT3. Significant correlation was found between TT4 and TT3 in all trimesters (r=0.35,P<0.001).Conclusion. The reference intervals of thyroid function tests in pregnant women differ among trimesters. Applying trimester-specific reference ranges of thyroid hormones is warranted in order to avoid misclassification of thyroid dysfunction during pregnancy.

scholarly journals Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women

2016 ◽  
Vol 20 (1) ◽  
pp. 101 ◽  
Author(s):  
Tarun Sekhri ◽  
JuhiAgarwal Juhi ◽  
Reena Wilfred ◽  
RatneshS Kanwar ◽  
Jyoti Sethi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Reference Intervals ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Function Tests

Establishment of reference intervals for thyroid function tests during pregnancy

2012 ◽  
Vol 45 (13-14) ◽  
pp. 1114
Author(s):  
K. Mourabit Amari ◽  
L. Bondaz ◽  
J. Girouard ◽  
C. Gagnon ◽  
J. Weisnagel ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Reference Intervals ◽  
Thyroid Function Tests ◽  
Function Tests

Reference intervals for neonatal thyroid function tests in the first 7 days of life

2018 ◽  
Vol 31 (10) ◽  
pp. 1113-1116 ◽  
Author(s):  
Michelle S. Jayasuriya ◽  
Kay W. Choy ◽  
Lit K. Chin ◽  
James Doery ◽  
Alice Stewart ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Medical Records ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Primary Hypothyroidism ◽  
Specific Reference ◽  
Rapid Decline ◽  
Thyroid Function Tests ◽  
Accurate Identification ◽  
Neonatal Hypothyroidism

Abstract Background: Prompt intervention can prevent permanent adverse neurological effects caused by neonatal hypothyroidism. Thyroid function changes rapidly in the first few days of life but well-defined age-specific reference intervals (RIs) for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free tri-iodothyronine (FT3) are not available to aid interpretation. We developed hour-based RIs using data mining. Methods: All TSH, FT4 and FT3 results with date and time of collection from neonates aged <7 days during 2005–2015 were extracted from the Monash Pathology database. Neonates with more than one episode of testing or with known primary hypothyroidism, identified by treating physicians or from medical records, were excluded from the analysis. The date and time of birth were obtained from the medical records. Results: Of the 728 neonates qualifying for the study, 569 had time of birth available. All 569 had TSH, 415 had FT4 and 146 had FT3 results. For age ≤24 h, 25–48 h, 49–72 h, 73–96 h, 97–120 h, 121–144 h and 145–168 h of life, the TSH RIs (2.5th–97.5th) (mIU/L) were 4.1–40.2, 3.2–29.6, 2.6–17.3, 2.2–14.7, 1.8–14.2, 1.4–12.7 and 1.0–8.3, respectively; the FT4 RIs (mean ± 2 standard deviation [SD]) (pmol/L) were 15.3–43.6, 14.7–53.2, 16.5–45.5, 17.8–39.4, 15.3–32.1, 14.5–32.6 and 13.9–30.9, respectively; the FT3 RIs (mean±2 SD) (pmol/L) were 5.0–9.4, 4.1–9.1, 2.8–7.8, 2.9–7.8, 3.5–7.2, 3.4–8.0 and 3.8–7.9, respectively. Conclusions: TSH and FT4 were substantially high in the first 24 h after birth followed by a rapid decline over the subsequent 168 h. Use of hour-based RIs in newborns allows for more accurate identification of neonates who are at risk of hypothyroidism.

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