Hyperprolactinemia and anti-psychotics: Prevalence and risk factors

2017 ◽  
Vol 41 (S1) ◽  
pp. S763-S763
Author(s):  
B. Walid ◽  
I. Marrag ◽  
R. Ben Soussia ◽  
F. Ellouze ◽  
M. Nasr
Keyword(s):  
Risk Factors ◽  
Side Effects ◽  
Elevated Serum ◽  
Clinical Signs ◽  
Cross Sectional Study ◽  
Serum Prolactin ◽  
Anti Psychotic ◽  
Cross Sectional ◽  
Competing Interest ◽  
Magnetic Resonance Imaging Mri

IntroductionHyperprolactinemia is a frequent side effect observed in patients treated with anti-psychotic drugs. The frequency of clinical signs usually correlates with elevated serum prolactin levels.ObjectivesTo estimate the prevalence of hyperprolactinemia among patients treated with a single anti-psychotic and specify the risk factors for its occurrence.MethodsCross-sectional study performed in a period of 6 months in the psychiatric department of Mahdia's hospital, for all patients seen in the consultation and treated with a single anti-psychotic for 12 weeks, with a stable dose, and meeting the inclusion and exclusion criteria of the study. Prolactin blood tests have been performed and confirmed by a second one in case of abnormality objectified in the first lab test results. A magnetic resonance imaging (MRI) was intended for patients with prolactin levels greater than 150 ng/mL.ResultsNinety-two patients were gathered. Prevalence of hyperprolactinemia was 34.8% of which 7.6% had prolactin levels greater than 150 ng/mL. Two macroadenomas’ cases were detected. The analytical study found 7 factors significantly correlated with hyperprolactinemia, which are: female sex, substance use, the presence of side effects, prescription of atypical anti-psychotics, the anti-psychotic treatment prescribed: haloperidol/amisulpride, doses of anti-psychotic greater than 1000 mg equivalent to chlorpromazine and the combination of psychotropic drugs.ConclusionProlactin blood test should be a systematical analysis for all patients treated with anti-psychotics, to prevent the short and long term side effects.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Prevalence and risk factors of postpartum depression

2017 ◽  
Vol 41 (S1) ◽  
pp. S362-S362 ◽  
Author(s):  
R. F Cherif ◽  
I. Feki ◽  
R. Sellami ◽  
D. Trigui ◽  
I. Baâti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Postpartum Depression ◽  
Depression Scale ◽  
Total Sample ◽  
Cross Sectional Study ◽  
School Level ◽  
Cross Sectional ◽  
Competing Interest ◽  
Associated Risk Factors ◽  
Almost All

IntroductionChildbirth represents for women a time of vulnerability to postpartum mood disorders. These disorders range in severity from the early maternal blues to postpartum psychosis. Along this spectrum is postpartum depression (PPD) that may have many risk factors.ObjectivesThe study aims to examine the prevalence of PPD and associated risk factors among a sample of Tunisian women receiving cares in the hospital of Sfax.MethodsThis is a descriptive cross-sectional study regarding 150 parturients examined during the first and the sixth week post-delivery. The EPDS (Edinburgh postnatal depression scale) was used to assess PPD.ResultsThe total sample had a mean age of 29.61 years. During the sixth week study period, 126 of 150 were examined. Almost all of the women have a low school level (82.7%). Only 9.3% had a personal psychiatric history. Multiparity was found in 43.3% of cases. The current pregnancy was undesired in 15.3% of cases. Sympathetic signs of pregnancy were reported by 64.7% of women. The prevalence of PPD in the first week was 14.7% and 19.8% in the sixth week after delivery. The PPD was associated with the maternal age (> 35 years), the low school level, the existence of mood personal background, the parity, the difficulty to accept the pregnancy and sympathetic signs of pregnancy.ConclusionPostpartum depression is common on our sample. Identifying risk factors of PPD allows clinicians to detect subgroups of women with an increased vulnerability who might receive early psychiatric care.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey

2021 ◽  
Vol 10 (12) ◽  
pp. 2629
Author(s):  
Abanoub Riad ◽  
Derya Sağıroğlu ◽  
Batuhan Üstün ◽  
Andrea Pokorná ◽  
Jitka Klugarová ◽  
...  
Keyword(s):  
Risk Factors ◽  
Side Effects ◽  
Healthcare Workers ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Vaccine Hesitancy ◽  
Public Confidence ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk

Background: COVID-19 vaccine hesitancy is a serious threat to mass vaccination strategies that need to be accelerated currently in order to achieve a substantial level of community immunity. Independent (non-sponsored) studies have a great potential to enhance public confidence in vaccines and accelerate their uptake process. Methods: A nationwide cross-sectional study for the side effects (SE) of CoronaVac was carried out in February 2021 among Turkish healthcare workers who were recently vaccinated. The questionnaire inquired about local and systemic SEs that occurred in the short-term, within four weeks, following vaccination. Results: A total of 780 healthcare workers were included in this study; 62.5% of them experienced at least one SE. Injection site pain (41.5%) was the most common local SE, while fatigue (23.6%), headache (18.7%), muscle pain (11.2%) and joint pain (5.9%) were the common systemic SEs. Female healthcare workers (67.9%) were significantly more affected by local and systemic SEs than male colleagues (51.4%). Younger age, previous infection, and compromised health status (chronic illnesses and regular medicines uptake) can be associated with an increased risk of CoronaVac SEs; Conclusions: The independent research shows a higher prevalence of CoronaVac SEs than what is reported by phase I–III clinical trials. In general, the results of this study confirm the overall safety of CoronaVac and suggest potential risk factors for its SEs. Gender-based differences and SEs distribution among age groups are worth further investigation.

scholarly journals Brucella suis Seroprevalence and Associated Risk Factors in Dogs in Eastern Australia, 2016 to 2019

2021 ◽  
Vol 8 ◽  
Author(s):  
Catherine C. Kneipp ◽  
Kate Sawford ◽  
Kate Wingett ◽  
Richard Malik ◽  
Mark A. Stevenson ◽  
...  
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Clinical Signs ◽  
Cross Sectional Study ◽  
Prevalence Survey ◽  
Cross Sectional ◽  
Feral Pigs ◽  
Hunting Dogs ◽  
Eastern Australia ◽  
Brucella Suis

Brucella suis is a zoonotic disease of feral pigs that also affects pig hunting dogs, pig hunters, veterinarians and veterinary staff. In recent years the incidence of B. suis in the eastern Australian states of New South Wales (NSW) and Queensland (QLD) has increased. A cross-sectional study was conducted to document the seroprevalence, geographical extent and risk factors for B. suis in dogs at-risk of contracting the disease. Eligible dogs were those that were known to hunt or consume feral pig meat. Dogs were enrolled through private veterinary clinics and/or directly by District Veterinarians in six regions of NSW and QLD. Blood was collected by venepuncture and tested for B. suis antibodies using the Rose Bengal Test (RBT) followed by a Complement Fixation Test (CFT) if they returned a positive RBT. Owners were invited to complete a questionnaire on the dogs' signalment, husbandry including hunting practices and locations, and any clinical signs referable to brucellosis. Of the 317 dogs included in the prevalence survey, 21 were seropositive returning a survey-adjusted true seroprevalence of 9.3 (95% CI 0.45 to 18) B. suis positive dogs per 100 dogs at-risk. True seroprevalence ranged from 0 to 24 B. suis positive dogs per 100 across eastern Australia, with the highest prevalence in central west NSW and southern QLD. Adjusted for other factors, dogs that shared a household with other seropositive dogs and those that traveled away from their home regions to hunt were more likely to be seropositive. Clinical signs at presentation were not predictive of serostatus, with seropositive and seronegative dogs equally likely to present with signs consistent with brucellosis. The results obtained from this study show that B. suis exposure is relatively common in dogs that have contact with feral pigs, with one in 10 testing seropositive. Further studies are needed to understand the progression and risk of transmission from seropositive dogs.

A serosurvey of Mycobacterium avium subsp. paratuberculosis infection of goats in the North of Portugal

2021 ◽  
Keyword(s):  
Risk Factors ◽  
Mycobacterium Avium ◽  
Clinical Signs ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
The North ◽  
Potential Risk Factors ◽  
Study Support ◽  
Mycobacterium Avium Subsp Paratuberculosis

Abstract To better understand the epizootiology of caprine paratuberculosis in the North of Portugal, a cross-sectional study was conducted from 2014 to 2015. The seroprevalence and risk factors for Mycobacterium avium subsp. paratuberculosis (Map) seropositivity were evaluated. Antibodies against Map were determined by a commercial ELISA. In 936 sera tested from 56 goat herds, 120 (12.8%, 95% CI: 10.8–15.1%) goats and 34 (60.7%, 95% CI: 47.6–72.4%) herds were positive. Risk factors for seropositivity were investigated by logistic regression models. The odds of Map seropositivity were found to be higher for animals with clinical signs, OR = 5.1 (95% CI: 2.7–9.6%), animals belonging to herds with previous wasting disease, OR = 2.3 (95% CI: 1.1–4.8%), and accumulation of manure in the herd, OR = 3.1 (95% CI: 1.7–5.7%). The potential risk factors identified in this study support the current recommendations for the control of paratuberculosis in these and other animals.

scholarly journals Revisiting the Risk Factors for Multiple Symptoms of Temporomandibular Disorders: A structured Cross-sectional Study

2020 ◽  
Vol 14 (1) ◽  
pp. 503-510
Author(s):  
Kamis Gaballah ◽  
Asma Alkubaisy ◽  
Asmaa Aba Baker ◽  
Alma Bawzeer ◽  
Rawan Awad
Keyword(s):  
Risk Factors ◽  
Temporomandibular Disorders ◽  
Dental Treatment ◽  
Clinical Signs ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Sleeping Problems ◽  
Multiple Symptoms ◽  
Had Scale

Background: The risk factors for Temporomandibular Disorders (TMD) are extensively studied, but the results showed no consistency. Only a small proportion of patients with TMD are likely to seek help and require treatment. Those individuals tend to present with multiple symptoms. This cohort of patients was not well investigated. Objective: The study aimed to examine the association between possible risk factors for presentation with multiple TMD symptoms. Methods: A population-based, cross-sectional study was conducted across 2101 individuals with an age range of 19-60 years. The condition was assessed via a detailed questionnaire comprising symptoms, habits, dental history, general health, sleep patterns, along with the completion of the Hospital Anxiety and Depression (HAD) scale, followed by an examination of the hypothesized clinical signs. The obtained data were tabulated and characterized the study population in a descriptive analysis in forms of percentages and frequencies. The significance level was set at P-value less than or equal to 0.005. The chi-squared test was implemented to assess the relationship between the multiple TMD symptoms reported and the potential risk factors. Results: Most participants reported a variable amount of stress. Moreover, 1528 (72.7 percent) mentioned abnormalities in sleep. About 80 percent had at least one TMD-related symptom. The multiple symptoms of TMD were identified among the 741 individuals. The following risk factors demonstrated association with a robust statistical significance (P=0.00), 1) occupation, 2) sleeping problems, 3) health concerns, 4) traumatic dental treatment, 5) various somatic symptoms, and 6) elevated HAD scale. When the outcomes of the clinical examination were analyzed, the statistical assessment could link soft tissue changes, namely; the cheek ridging and tongue indentations (P 0.00), with multiple symptoms of the condition. Conclusion: Multiple TMD symptoms were prevalent among individuals with elevated stress, abnormal sleep pattern, traumatic dental treatment, elevated HAD scale. The results highlighted the importance of psychological factors in the pathogenesis of TMD.

PRRSV: Risikofaktoren und Herdenprävalenz in Deutschland

2019 ◽  
Vol 47 (02) ◽  
pp. 132-132
Author(s):  
Sebastian Ganz
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Respiratory Syndrome Virus ◽  
Sectional Study ◽  
Cross Sectional ◽  
Klinische Symptome

Nathues C, Janssen E, Duengelhoef A et al. Cross-sectional study on risk factors for Porcine Reproductive and Respiratory Syndrome virus sow herd instability in German breeding herds. Acta Vet Scand 2018; 60 (1): 1–8 In mit PRRSV (Porcine Reproductive and Respiratory Syndrom Virus) infizierten Schweinebeständen zeigen die Tiere oftmals ernsthafte klinische Symptome. Die Schwere der Symptomatik hängt von der Virulenz der jeweiligen Virusstämme ab. Deshalb ist die Impfung gegen diesen Erreger sinnvoll und wird empfohlen, auch wenn sie nicht immer klinische Fälle verhindert bzw. das Virus vollends eliminiert. Aufgrund dessen rückt die Prävention durch Verbesserung der innerbetrieblichen Abläufe zunehmend in den Fokus. Um solche Maßnahmen erfolgreich etablieren zu können, ist es wichtig, den epidemiologischen Status der Herde und mögliche Risikofaktoren zu kennen. Ziel der Studie war deshalb, die Prävalenz der Infektion in Sauenbetrieben in Norddeutschland zu eruieren und verschiedene Arbeitsabläufe hinsichtlich des Risikos der Erregerverbreitung zu untersuchen.

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