Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins

Larval form of Taenia solium causes cysticercosis that commonly involves the central nervous system. Other sites of manifestation are eye, gastrointestinal system, skeletal muscles and subcutaneous tissues. Isolated muscular involvement is rare with only a handful of cases reported in the literature. We present this case of an isolated symtomatic hand swelling due to Myocysticercosis which pose diagnostic dilemma. This should be considered in differential diagnosis in our developing nation and especially in endemic region. High resolution ultrasound of the hand (thenar region) helped in the diagnosis and is often diagnostic like in our case. The treatment of choice of an isolated symptomatic lesion without involvement of central nervous system is surgical excision which we did followed by short course of antiheminthic and anti-inflammatory medication for two weeks.

Cerebellar Neurocysticercosis as Long-Term Complication of Allogeneic Haematopoietic Stem Cell Transplantation from Haploidentical Donor

Case Reports in Infectious Diseases ◽

10.1155/2019/4603130 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4

Author(s):

Federico Meconi ◽

Giulia Ciangola ◽

Benedetta Mariotti ◽

Raffaella Cerretti ◽

Laura Cudillo ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Stem Cell ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Haematopoietic Stem Cell Transplantation ◽

Taenia Solium ◽

Haematopoietic Stem Cell ◽

Neurocysticercosis, an infection of the central nervous system with the larval stage of the cestode Taenia solium, is uncommon in developed countries. We report a case of allogeneic haematopoietic stem cell transplantation from a haploidentical donor complicated, in the long term, by T. solium infection of the central nervous system and successfully treated with empiric antiparasitic therapy with albendazole plus dexamethasone. Revised diagnostic criteria proposed by Del Brutto et al. were used for the definitive diagnosis of cerebellar neurocysticercosis.

Cysticercosis Involving Muscle of Mastication: A Review and Report of Two Cases

Case Reports in Dentistry ◽

10.1155/2013/814126 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Sarbjeet Singh ◽

V. Sreenivasan ◽

Kanika Garg ◽

Nikhel Dev Wazir ◽

Jaspal Singh Rajput ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Taenia Solium ◽

Parasitic Infection ◽

Primary Site ◽

Common Disease ◽

Temporalis Muscle ◽

Mri Findings ◽

Larval Stages ◽

Cysticercosis is a parasitic infection caused by the larval stages of the parasitic cestode,Taenia solium. It is a common disease in developing countries where it is also endemic. The central nervous system (CNS) is the most important primary site of infection and the disease can present with solitary or multiple space occupying lesions. Cases of cysticercosis presenting as isolated muscle mass (pseudotumours) without involvement of the CNS have also been recently described in the literature. We present two cases who presented to us with pain, swelling, and tenderness involving the temporalis muscle along with trismus. Ultrasonography and MRI findings were suggestive of cysticercosis involving the temporalis muscle which resolved after the albendazole therapy.

Bruns' syndrome and racemose neurocysticercosis: a case report

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86822012000200027 ◽

2012 ◽

Vol 45 (2) ◽

pp. 269-271 ◽

Cited By ~ 5

Author(s):

Roberta Diehl Rodriquez ◽

Denise Neme da Silva Crestani ◽

José Otávio Dworzecki Soares ◽

Paulo Roberto Franceshini ◽

Ronnie Petersen Alves ◽

...

Keyword(s):

Central Nervous System ◽

Immune Response ◽

Nervous System ◽

Taenia Solium ◽

Clinical Manifestations ◽

Head Posture ◽

Stage Of Development ◽

Type Size ◽

Basal Cisterns

Cysticercosis is an infection caused by the larval stage of the tapeworm Taenia solium. The parasite may infect the central nervous system, causing neurocysticercosis (NCC). The clinical manifestations depend on load, type, size, location, stage of development of the cysticerci, and the host's immune response against the parasite. The racemose variety occurs in the ventricles or basal cisterns and is a malignant form. Mobile ventricular mass can produce episodic hydrocephalus on changing head posture with attacks of headache, vomiting, and vertigo, triggered by abrupt movement of the head, a phenomenon called Bruns' syndrome (BS). We report a patient with racemose NCC and BS.

Cerebral cysticercosis in Campina Grande, Paraíba - northern Brazil: computerized tomography diagnosis importance

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x1996000100015 ◽

1996 ◽

Vol 54 (1) ◽

pp. 94-97 ◽

Cited By ~ 12

Author(s):

Thiago D. Gonçalves-Coêlho ◽

Matheus Diniz G. Coelho

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Endemic Area ◽

Taenia Solium ◽

Larval Form ◽

Cysticercus Cellulosae ◽

Pedro I ◽

Cerebral Cysticercosis ◽

Northern Brazil

Neurocysticercosis is the infection of the central nervous system by the larval form of Taenia solium , the Cysticercus cellulosae. We studied 4011 computerized tomographies performed in TomoHPI Radioimaging Service, Hospital Pedro I, Campina Grande PB, Northern Brazil, since its installation on August 1993 to July 1995. 41 patients were diagnosed as having Cysticercus cerebral infestation, corresponding to an incidence of 1.02%. No cases were related in Campina Grande PB during 1991 according to hospitalizations under prospective payment rates. After this radioimaging service installation, we observed 1.86 cases per month. We conclude that Campina Grande has to be included as an endemic area of neurocysticercosis, needing health service measures to cease the cycle Taenia-Cysticercus, the only way to get rid of such a serious problem.

A rare case report of solitary intramuscular cysticercosis of right forearm involving the extensor muscle group

International Surgery Journal ◽

10.18203/2349-2902.isj20181157 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1595

Author(s):

Vinod Kumar ◽

Mushir Reyaz ◽

Shankar Kumar Gupta ◽

Pawan Kumar

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Rare Case ◽

Taenia Solium ◽

Muscle Group ◽

Larval Form ◽

Diagnostic Challenge ◽

Extensor Muscles ◽

Rare Case Report ◽

Cysticercosis is an infection with the larval form of the Taenia solium that commonly involves the central nervous system. Isolated muscular involvement is rare with only a handful of cases reported in the literature. We present a case of isolated cysticercosis of the extensor muscles of the forearm that presented a diagnostic challenge. High resolution ultrasound of the forearm helped in the diagnosis and the patient was managed successfully on anti-helminths and anti-inflammatory medications.

The gateway reflex: breaking through the blood barriers

International Immunology ◽

10.1093/intimm/dxab064 ◽

2021 ◽

Author(s):

Kaoru Murakami ◽

Yuki Tanaka ◽

Masaaki Murakami

Keyword(s):

Central Nervous System ◽

T Cells ◽

Endothelial Cells ◽

Nervous System ◽

Neural Circuits ◽

Inflammatory Diseases ◽

Special Focus ◽

Tissue Specific ◽

Pass Through

Abstract We have been studying inflammatory diseases, with a special focus on IL-6, and discovered two concepts related to inflammation development. One is the gateway reflex, which is induced by the activation of specific neural circuits followed by establishing gateways for autoreactive CD4+ T cells to pass through blood barriers toward the central nervous system (CNS) and retina during tissue-specific inflammatory diseases. We found that the formation of these gateways is dependent on the IL-6 amplifier, which is machinery for enhanced NF-κB activation in endothelial cells at specific sites. We have found five gateway reflexes in total. Here, we introduce the gateway reflex and the IL-6 amplifier.

Neurosurgical considerations of cysticercosis of the central nervous system

Journal of Neurosurgery ◽

10.3171/jns.1981.55.3.0382 ◽

1981 ◽

Vol 55 (3) ◽

pp. 382-389 ◽

Cited By ~ 52

Author(s):

W. Eugene Stern

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Surgical Procedures ◽

Operative Mortality ◽

Taenia Solium ◽

Larval Form ◽

Content Type ◽

Fine Print

✓ Infestation of the central nervous system (CNS) by the larval form of Taenia solium can be etiological for one or more of several clinicopathological manifestations. Experience gained from treating 18 patients forms the basis for a classification of this disease and for observations upon therapy. Twenty-three surgical procedures in 15 of the 18 patients provide the foundation for comment on operative treatment in management. Whereas most procedures are palliative, eradication of the CNS disease may be achieved in cases of solitary intraventricular cysts. There has been no operative mortality.

Parasitoses of the human central nervous system

Journal of Helminthology ◽

10.1017/s0022149x12000600 ◽

2012 ◽

Vol 87 (3) ◽

pp. 257-270 ◽

Cited By ~ 49

Author(s):

J. Finsterer ◽

H. Auer

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Trichinella Spiralis ◽

Taenia Solium ◽

Toxocara Canis ◽

Neurological Deficits ◽

Diagnostic Tools ◽

Surgery Outcome ◽

Spirometra Mansoni

AbstractCerebral involvement in parasitoses is an important clinical manifestation of most of the human parasitoses. Parasites that have been described to affect the central nervous system (CNS), either as the dominant or as a collateral feature, include cestodes (Taenia solium (neurocysticerciasis), Echinococcus granulosus (cerebral cystic echinococcosis), E. multilocularis (cerebral alveolar echinococcosis), Spirometra mansoni (neurosparganosis)), nematodes (Toxocara canis and T. cati (neurotoxocariasis), Trichinella spiralis (neurotrichinelliasis), Angiostrongylus cantonensis and A. costaricensis (neuroangiostrongyliasis), Gnathostoma spinigerum (gnathostomiasis)), trematodes (Schistosoma mansoni (cerebral bilharziosis), Paragonimus westermani (neuroparagonimiasis)), or protozoa (Toxoplasma gondii (neurotoxoplasmosis), Acanthamoeba spp. or Balamuthia mandrillaris (granulomatous amoebic encephalitis), Naegleria (primary amoebic meningo-encephalitis), Entamoeba histolytica (brain abscess), Plasmodium falciparum (cerebral malaria), Trypanosoma brucei gambiense/rhodesiense (sleeping sickness) or Trypanosoma cruzi (cerebral Chagas disease)). Adults or larvae of helminths or protozoa enter the CNS and cause meningitis, encephalitis, ventriculitis, myelitis, ischaemic stroke, bleeding, venous thrombosis or cerebral abscess, clinically manifesting as headache, epilepsy, weakness, cognitive decline, impaired consciousness, confusion, coma or focal neurological deficits. Diagnosis of cerebral parasitoses is dependent on the causative agent. Available diagnostic tools include clinical presentation, blood tests (eosinophilia, plasmodia in blood smear, antibodies against the parasite), cerebrospinal fluid (CSF) investigations, imaging findings and occasionally cerebral biopsy. Treatment relies on drugs and sometimes surgery. Outcome of cerebral parasitoses is highly variable, depending on the effect of drugs, whether they are self-limiting (e.g. Angiostrongylus costaricensis) or whether they remain undetected or asymptomatic, like 25% of neurocysticerciasis cases.

EXPERIMENTAL STUDY OF THE VOLATILE PETROLEUM PRODUCTS EFFECT ON THE CENTRAL NERVOUS SYSTEM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i3.21587 ◽

2018 ◽

Vol 11 (3) ◽

pp. 350

Author(s):

Ragim Almamed Orujov ◽

Rana Anver Jafarova

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Skeletal Muscles ◽

Muscle Tone ◽

Motor Reaction ◽

Animal Hypnosis ◽

Static Work ◽

Functional Changes ◽

Electric Pulses ◽

Objective: The goal of the research is studying the functional changes in the central nervous system against the background of intoxication with the minimum dosages of gasoline, benzene and acetone.Methods: The research was performed on 45 white mice divided into 3 groups; each group received corresponding hydrocarbon in the exposure chamber by inhaling. The functional state of the CNS was assessed with a complex of integral tests: By summation of subliminal pulses, the ability of animals to restore rectilinear movement after centrifugation, by the tone of skeletal muscles, and by the activity of muscle static work.Results: The durations of the narcosis phases in case of acute inhalation poisoning are different for all studied substances. The study of the functional changes in the CNS on the background of intoxication with low dosages has revealed that at the first exposure to benzene for activating the motor reaction the required number of electric pulses from the outside increases, the muscle tone increases, the ability to static work reduces, and the time for rectilinear movement and “animal hypnosis” increases. At the same time, on the background of intoxication during the fifth exposure, a decrease is observed in the number of electric pulses from the outside for activating the motor reaction, the muscle tone remains increased, the ability to static work is reduced, and the time of “animal hypnosis” is shorter than that during the first exposure.Conclusion: Against the background of the repeated use of small doses of benzene, the CNS adapts to the action of the toxic factor. With that, the ability of the CNS to sum the subliminal pulses, the cholinergic innervation of the skeletal muscles tone and other integral tests during the fifth exposure change less than during the first exposure.