scholarly journals Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential

2012 ◽  
Vol 132 (1) ◽  
pp. 482-486 ◽  
Author(s):  
Josiana A. Vaz ◽  
Gabriela M. Almeida ◽  
Isabel C.F.R. Ferreira ◽  
Anabela Martins ◽  
M. Helena Vasconcelos
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Line ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Cytotoxic Potential ◽  
Cycle Arrest ◽  
Line Identification ◽  
Cell Line Identification

scholarly journals The effects of Benjakul extract and its isolated compounds on cell cycle arrest and apoptosis in human non-small cell lung cancer cell line NCI-H226

2021 ◽  
Vol 16 (2) ◽  
pp. 129
Author(s):  
Arunporn Itharat ◽  
Ruchilak Rattarom ◽  
Pintusorn Hansakul ◽  
Intouch Sakpakdeejaroen ◽  
Buncha Ooraikul ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Small Cell Lung Cancer ◽  
Cell Line ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Cycle Arrest

Effect of UbcH10 gene silencing on cell proliferation and cell cycle of lung cancer cell line NCI-H226

2013 ◽  
Vol 32 (6) ◽  
pp. 608-612
Author(s):  
Li-ming ZHAO ◽  
Guang-yuan SUN ◽  
Li-rong LOU ◽  
Liang-zhe WANG ◽  
Zheng FANG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Gene Silencing ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell

scholarly journals Melissa officinalis L. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis

2018 ◽  
Vol 9 (6) ◽  
pp. 3134-3142 ◽  
Author(s):  
D. B. Magalhães ◽  
I. Castro ◽  
V. Lopes-Rodrigues ◽  
J. M. Pereira ◽  
L. Barros ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Line ◽  
Mediterranean Region ◽  
Cancer Cell Line ◽  
Ethanolic Extract ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Melissa Officinalis ◽  
The Family

Melissa officinalis is a plant from the family Lamiaceae, native in Europe particularly in the Mediterranean region.

Effect of zoledronic acid combined with cisplatin and paclitaxel on inhibition of non-small cell lung cancer cell lines

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e19095-e19095
Author(s):  
Z. Gao ◽  
B. Han ◽  
J. Teng
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Zoledronic Acid ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Antitumor Effects

e19095 Backgrounds: Recent studies reported that zoledronic acid, a biphosphonate with proposed apoptotic activity, could cause a direct antitumor effect. Our prior study [J Clin Oncol 26: 2008 (May 20 suppl; abstr 19116)] reported that Zoledronic acid combined with Cisplatin shows significantly synergistic antitumor effects on lung cancer cell line A549 and subcutaneous implanted tumor on nude mice. Investigate whether zoledronic acid, augmented the cytotoxicity of cisplatin and/or paclitaxel in A549 lung cancer cell line. Methods: This cell line was subjected to different concentrations of the above chemotherapeutic agents and zoledronic acid. Cytotoxicity was assessed by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide) assay. Flow cytometry was used to examine cell cycle,cell apoptosis rate. Results: Zoledronic acid in in 50 micromolar (mM) concentration augmented the cytotoxicity by cisplatin in 10μmol/L and paclitaxel in 5μmol/L. Zoledronic acid could inhibit the proliferation of lung cancer cells in vitro,which was associated with arresting of G1 phase and inducing apoptosis by a time-dependent and dose-dependentmanner. The apoptosis rate of cell increased after zoledronic acid combined with cisplatin and/or paclitaxel. Conclusions: Zoledronic acid can induce apoptosis and block cell cycle of lung cancer cells. Zoledronic acid has also shown synergistic antitumor effects when combined with cisplatin and/or paclitaxel. The clinical potential of this finding should be further studied. No significant financial relationships to disclose.

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