Multiparametric protocol for the determination of thiol redox state in living matter

2014 ◽  
Vol 74 ◽  
pp. 85-98 ◽  
Author(s):  
Konstantinos Grintzalis ◽  
Ioannis Papapostolou ◽  
Dimitris Zisimopoulos ◽  
Irene Stamatiou ◽  
Christos D. Georgiou
Keyword(s):  
Redox State ◽  
Living Matter ◽  
Thiol Redox State ◽  
Thiol Redox

Fluorometric determination of thiol redox state

2005 ◽  
Vol 383 (6) ◽  
pp. 923-929 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
Christos D. Georgiou
Keyword(s):  
Redox State ◽  
Fluorometric Determination ◽  
Thiol Redox State ◽  
Thiol Redox

scholarly journals The thiol redox state of lymphoid organs is modified by immunization: Role of different immune cell populations

2008 ◽  
Vol 38 (9) ◽  
pp. 2419-2425 ◽  
Author(s):  
Patrizia Castellani ◽  
Giovanna Angelini ◽  
Laura Delfino ◽  
Andrea Matucci ◽  
Anna Rubartelli
Keyword(s):  
Redox State ◽  
Immune Cell ◽  
Lymphoid Organs ◽  
Cell Populations ◽  
Thiol Redox State ◽  
Thiol Redox

scholarly journals The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer

2021 ◽  
Vol 22 (12) ◽  
pp. 6183
Author(s):  
Delia Acevedo-León ◽  
Lidia Monzó-Beltrán ◽  
Segundo Ángel Gómez-Abril ◽  
Nuria Estañ-Capell ◽  
Natalia Camarasa-Lillo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Redox State ◽  
Reduced Glutathione ◽  
Redox Status ◽  
Oxidation Products ◽  
Interventional Study ◽  
Thiol Redox State ◽  
Thiol Redox ◽  
Glutathione Redox

The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to identify the mechanisms of ROS-induced carcinogenesis; however, the validation of OS byproducts as potential tumor markers (TMs) remains to be established. This interventional study included a total of 80 colorectal cancer (CRC) patients and 60 controls. By measuring reduced glutathione (GSH), its oxidized form (GSSG), and the glutathione redox state in terms of the GSSG/GSH ratio in the serum of CRC patients, we identified significant changes as compared to healthy subjects. These findings are compatible with the effectiveness of glutathione as a TM. The thiol redox state showed a significant increase towards oxidation in the CRC group and correlated significantly with both the tumor state and the clinical evolution. The sensitivity and specificity of serum glutathione levels are far above those of the classical TMs CEA and CA19.9. We conclude that the GSSG/GSH ratio is a simple assay which could be validated as a novel clinical TM for the diagnosis and monitoring of CRC.

scholarly journals Detecting intracellular thiol redox state in leukaemia and heterogeneous immune cell populations: An optimised protocol for digital flow cytometers

MethodsX ◽  
2018 ◽  
Vol 5 ◽  
pp. 1473-1483 ◽  
Author(s):  
Alex J. Wadley ◽  
Rhys G. Morgan ◽  
Kate J. Heesom ◽  
Paul S. Hole ◽  
Steven J. Coles
Keyword(s):  
Redox State ◽  
Immune Cell ◽  
Cell Populations ◽  
Thiol Redox State ◽  
Thiol Redox

scholarly journals Increased hepatic telomerase activity in a rat model of iron overload: A role for altered thiol redox state?

2007 ◽  
Vol 42 (2) ◽  
pp. 228-235 ◽  
Author(s):  
Kyle E. Brown ◽  
M. Meleah Mathahs ◽  
Kimberly A. Broadhurst ◽  
Mitchell C. Coleman ◽  
Lisa A. Ridnour ◽  
...  
Keyword(s):  
Iron Overload ◽  
Rat Model ◽  
Redox State ◽  
Telomerase Activity ◽  
Thiol Redox State ◽  
Thiol Redox

The modulation of thiol redox state affects the production and metabolism of hydrogen peroxide by heart mitochondria

2005 ◽  
Vol 441 (2) ◽  
pp. 112-122 ◽  
Author(s):  
Maria Pia Rigobello ◽  
Alessandra Folda ◽  
Guido Scutari ◽  
Alberto Bindoli
Keyword(s):  
Hydrogen Peroxide ◽  
Redox State ◽  
Heart Mitochondria ◽  
Thiol Redox State ◽  
Thiol Redox
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