A comparative study of wound dressings loaded with silver sulfadiazine and silver nanoparticles: In vitro and in vivo evaluation

2019 ◽  
Vol 564 ◽  
pp. 350-358 ◽  
Author(s):  
Mina Mohseni ◽  
Amir Shamloo ◽  
Zahra Aghababaie ◽  
Homa Afjoul ◽  
Shabnam Abdi ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Comparative Study ◽  
Silver Sulfadiazine ◽  
Wound Dressings ◽  
In Vivo Evaluation

scholarly journals Species-Specific in vitro and in vivo Evaluation of Toxicity of Silver Nanoparticles Stabilized with Gum Arabic Protein

2020 ◽  
Vol Volume 15 ◽  
pp. 7359-7376
Author(s):  
Joana S Maziero ◽  
Velaphi C Thipe ◽  
Sizue O Rogero ◽  
Adriana K Cavalcante ◽  
Kelme C Damasceno ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Gum Arabic ◽  
In Vivo Evaluation ◽  
Species Specific

scholarly journals Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

2020 ◽  
Vol 21 (7) ◽  
pp. 2375 ◽  
Author(s):  
Zannatul Ferdous ◽  
Abderrahim Nemmar
Keyword(s):  
Silver Nanoparticles ◽  
Biomedical Application ◽  
Health Impact ◽  
Surgical Instruments ◽  
Wound Dressings ◽  
Mechanisms Of Toxicity ◽  
Biodistribution Studies ◽  
Exposure In Vivo

Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among the various ENMs, silver nanoparticles (AgNPs) have become one of the most explored nanotechnology-derived nanostructures and have been intensively investigated for their unique physicochemical properties. The widespread commercial and biomedical application of nanosilver include its use as a catalyst and an optical receptor in cosmetics, electronics and textile engineering, as a bactericidal agent, and in wound dressings, surgical instruments, and disinfectants. This, in turn, has increased the potential for interactions of AgNPs with terrestrial and aquatic environments, as well as potential exposure and toxicity to human health. In the present review, after giving an overview of ENMs, we discuss the current advances on the physiochemical properties of AgNPs with specific emphasis on biodistribution and both in vitro and in vivo toxicity following various routes of exposure. Most in vitro studies have demonstrated the size-, dose- and coating-dependent cellular uptake of AgNPs. Following NPs exposure, in vivo biodistribution studies have reported Ag accumulation and toxicity to local as well as distant organs. Though there has been an increase in the number of studies in this area, more investigations are required to understand the mechanisms of toxicity following various modes of exposure to AgNPs.

Comparative study on DOTA-derivatized bombesin analog labeled with 90Y and 177Lu: in vitro and in vivo evaluation

2009 ◽  
Vol 36 (6) ◽  
pp. 591-603 ◽  
Author(s):  
Eftychia Koumarianou ◽  
Renata Mikołajczak ◽  
Dariusz Pawlak ◽  
Xhristos Zikos ◽  
Pinelopi Bouziotis ◽  
...  
Keyword(s):  
Comparative Study ◽  
In Vivo Evaluation

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

2021 ◽  
pp. 088532822199592
Author(s):  
Graziele Louize Policarpio da Silva ◽  
Laís Caroline de Assunção Morais ◽  
Juliana Bonametti Olivato ◽  
Juliano Marini ◽  
Priscileila Colerato Ferrari
Keyword(s):  
Zeta Potential ◽  
Mechanical Stability ◽  
Thermoplastic Starch ◽  
Halloysite Nanotubes ◽  
Cassava Starch ◽  
Silver Sulfadiazine ◽  
Wound Dressings ◽  
Vapor Permeability

(Bio)nanocomposites have been studied for biomedical applications, including the treatment of wounds. However, wound infection is one of the main problems of wound care management, and the use of wound dressings with antibacterial agents is essential. This work focused on developing and characterizing silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites potentially suitable as antimicrobial dressing. Silver sulfadiazine was complexed inside the halloysite nanotubes lumen, and the drug-loaded nanotubes were incorporated in thermoplastic starch dispersion, forming the (bio)nanocomposites. The silver sulfadiazine-loaded halloysite and the (bio)nanocomposite were characterized by zeta potential, scanning electron microscopy, X-ray diffraction, and infrared spectroscopy. The dressing properties of (bio)nanocomposites (water vapor permeability and mechanical stability) and their antimicrobial efficacy by Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were also evaluated. Physicochemical studies suggested the silver sulfadiazine-loaded halloysite complexation (zeta potential of −38.9 mV) and its interactions with the starch forming the nanocomposites. The silver sulfadiazine-loaded halloysite/starch-based (bio)nanocomposites possessed a homogeneous and organized structure. Also, they had mechanical properties to be used as a dressing (13.73 ± 3.09 MPa and 3.17 ± 1.28% of elongation at break), and its permeability (6.18 ± 0.43 (10−13) g.Pa−1.s−1.m−1) could be able to maintain the environmental moisture at the wound surface. Besides that, the (bio)nanocomposites acted against the studied bacteria, being a potential contact antimicrobial and biodegradable wound dressing. Finally, the developed (bio)nanocomposites are semi-occlusive and good candidates for dry wounds to be widely in vitro and in vivo tested as controlled silver sulfadiazine delivery dressing.

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