Comparative Study on the Protective Effect of Chlorogenic Acid and 3-(3-Hydroxyphenyl) Propionic Acid against Cadmium-Induced Erythrocyte Cytotoxicity: In Vitro and In Vivo Evaluation

2021 ◽  
Vol 69 (13) ◽  
pp. 3859-3870
Author(s):  
Dai Cheng ◽  
Qi Song ◽  
Yixin Ding ◽  
Qianqian Yu ◽  
Yutong Liu ◽  
...  
Keyword(s):  
Comparative Study ◽  
Protective Effect ◽  
Chlorogenic Acid ◽  
Propionic Acid ◽  
In Vivo Evaluation

Comparative study on DOTA-derivatized bombesin analog labeled with 90Y and 177Lu: in vitro and in vivo evaluation

2009 ◽  
Vol 36 (6) ◽  
pp. 591-603 ◽  
Author(s):  
Eftychia Koumarianou ◽  
Renata Mikołajczak ◽  
Dariusz Pawlak ◽  
Xhristos Zikos ◽  
Pinelopi Bouziotis ◽  
...  
Keyword(s):  
Comparative Study ◽  
In Vivo Evaluation

scholarly journals Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
George Briassoulis ◽  
Efrossini Briassouli ◽  
Diana-Michaela Fitrolaki ◽  
Ioanna Plati ◽  
Kleovoulos Apostolou ◽  
...  
Keyword(s):  
Heat Shock ◽  
Animal Models ◽  
Heat Shock Protein ◽  
Comparative Study ◽  
Protective Effect ◽  
Animal Studies ◽  
Human Studies ◽  
Heat Shock Protein 72

Heat shock protein 72 (Hsp72) exhibits a protective role during times of increased risk of pathogenic challenge and/or tissue damage. The aim of the study was to ascertain Hsp72 protective effect differences between animal and human studies in sepsis using a hypothetical “comparative study” model. Forty-one in vivo (56.1%), in vitro (17.1%), or combined (26.8%) animal and 14 in vivo (2) or in vitro (12) human Hsp72 studies (P<0.0001) were enrolled in the analysis. Of the 14 human studies, 50% showed a protective Hsp72 effect compared to 95.8% protection shown in septic animal studies (P<0.0001). Only human studies reported Hsp72-associated mortality (21.4%) or infection (7.1%) or reported results (14.3%) to be nonprotective (P<0.001). In animal models, any Hsp72 induction method tried increased intracellular Hsp72 (100%), compared to 57.1% of human studies (P<0.02), reduced proinflammatory cytokines (28/29), and enhanced survival (18/18). Animal studies show a clear Hsp72 protective effect in sepsis. Human studies are inconclusive, showing either protection or a possible relation to mortality and infections. This might be due to the fact that using evermore purified target cell populations in animal models, a lot of clinical information regarding the net response that occurs in sepsis is missing.

In silico designing, in vitro and in vivo evaluation of potential PPAR-γ agonists derived from aryl propionic acid scaffold

2021 ◽  
Vol 106 ◽  
pp. 104458
Author(s):  
Chetna Kharbanda ◽  
Mohammad Sarwar Alam ◽  
Hinna Hamid ◽  
Yakub Ali ◽  
Syed Nazreen ◽  
...  
Keyword(s):  
Propionic Acid ◽  
In Silico ◽  
In Vivo Evaluation ◽  
Ppar Γ

A comparative study of wound dressings loaded with silver sulfadiazine and silver nanoparticles: In vitro and in vivo evaluation

2019 ◽  
Vol 564 ◽  
pp. 350-358 ◽  
Author(s):  
Mina Mohseni ◽  
Amir Shamloo ◽  
Zahra Aghababaie ◽  
Homa Afjoul ◽  
Shabnam Abdi ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Comparative Study ◽  
Silver Sulfadiazine ◽  
Wound Dressings ◽  
In Vivo Evaluation

Comparative Study of PLGA in-situ Implant and Nanoparticle Formulations of Entecavir; in-vitro and in-vivo evaluation

2020 ◽  
Vol 56 ◽  
pp. 101585
Author(s):  
Margrit M. Ayoub ◽  
Bhaskara Jasti ◽  
Neveen G. Elantouny ◽  
Hanan Elnahas ◽  
Fakhr-eldin Ghazy
Keyword(s):  
Comparative Study ◽  
In Vivo Evaluation ◽  
In Situ Implant
Sign in / Sign up

Export Citation Format

Share Document