scholarly journals Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study

2016 ◽  
Vol 75 (4) ◽  
pp. 698-705 ◽  
Author(s):  
Erin X. Wei ◽  
Abrar A. Qureshi ◽  
Jiali Han ◽  
Tricia Y. Li ◽  
Eunyoung Cho ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Features ◽  
Prospective Observational Study ◽  
Men And Women ◽  
Melanoma In Situ

Hump-nosed pit viper (Hypnale hypnale and Hypnale zara) envenoming in Deniyaya, Sri Lanka: Epidemiological and clinical features from a prospective observational study

Toxicon ◽  
2021 ◽  
Vol 189 ◽  
pp. 19-23
Author(s):  
E.W.R.A. Witharana ◽  
A. Gnanathasan ◽  
A.S. Dissanayake ◽  
S.K.J. Wijesinghe ◽  
S.C.L. Kadahetti ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Observational Study ◽  
Clinical Features ◽  
Prospective Observational Study

scholarly journals Multifocal BRAFV600E-Mutated Melanoma in situ on the Foot

2015 ◽  
Vol 7 (3) ◽  
pp. 322-327
Author(s):  
Eimei Iwama ◽  
Taku Fujimura ◽  
Yoshiyuki Kusakari ◽  
Takahiro Haga ◽  
Setsuya Aiba
Keyword(s):  
Skin Cancer ◽  
Clinical Features ◽  
Braf Mutation ◽  
Spontaneous Regression ◽  
Normal Skin ◽  
Brafv600e Mutation ◽  
Braf Gene ◽  
Melanoma In Situ ◽  
Pigmented Lesions

Melanoma is an aggressive skin cancer that originates from melanocytes, and about one half of melanoma cases possess a BRAF mutation. Together with PD-L1 expression, the BRAFV600E mutation is one of the optimal therapeutic targets for the treatment of melanoma. In this report, we describe a case of multifocal melanoma in situ on the foot, which carried the p.V600E mutation in the BRAF gene. Interestingly, the spotted melanoma lesion is demarcated by normal skin, and in all spotted pigmented lesions, there were no signs of dermal invasion of melanoma cells or spontaneous regression. Our case presented atypical clinical features, which might correlate with the local mutations of BRAF gene and the immunological expression of PD-L1.

scholarly journals Refining the clinical features of serotonin syndrome: A prospective observational study of 45 patients

2019 ◽  
Vol 22 (1) ◽  
pp. 52 ◽  
Author(s):  
Sanjay Prakash ◽  
Chaturbhuj Rathore ◽  
KaushikKumar Rana ◽  
Ankit Dave ◽  
Hemant Joshi ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Features ◽  
Prospective Observational Study ◽  
Serotonin Syndrome
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