Does early response predict subsequent remission in bipolar depression treated with repeated sleep deprivation combined with light therapy and lithium?

2018 ◽  
Vol 229 ◽  
pp. 371-376 ◽  
Author(s):  
Masahiro Suzuki ◽  
Sara Dallaspezia ◽  
Clara Locatelli ◽  
Makoto Uchiyama ◽  
Cristina Colombo ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Bipolar Depression ◽  
Light Therapy ◽  
Early Response

Combined Total Sleep Deprivation and Light Therapy in the Treatment of Drug-Resistant Bipolar Depression

2005 ◽  
Vol 66 (12) ◽  
pp. 1535-1540 ◽  
Author(s):  
Francesco Benedetti ◽  
Barbara Barbini ◽  
Mara Cigala Fulgosi ◽  
Cristina Colombo ◽  
Sara Dallaspezia ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Bipolar Depression ◽  
Light Therapy ◽  
Drug Resistant ◽  
Total Sleep Deprivation

Spectroscopic correlates of antidepressant response to sleep deprivation and light therapy: A 3.0 Tesla study of bipolar depression

2009 ◽  
Vol 173 (3) ◽  
pp. 238-242 ◽  
Author(s):  
Francesco Benedetti ◽  
Giovanna Calabrese ◽  
Alessandro Bernasconi ◽  
Marcello Cadioli ◽  
Cristina Colombo ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Bipolar Depression ◽  
Light Therapy ◽  
Antidepressant Response ◽  
3.0 Tesla

Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction

2000 ◽  
Vol 95 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Cristina Colombo ◽  
Adelio Lucca ◽  
Francesco Benedetti ◽  
Barbara Barbini ◽  
Euridice Campori ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Bipolar Depression ◽  
Light Therapy ◽  
Total Sleep Deprivation ◽  
Main Effects

Rapid Treatment Response of Suicidal Symptoms to Lithium, Sleep Deprivation, and Light Therapy (Chronotherapeutics) in Drug-Resistant Bipolar Depression

2013 ◽  
Vol 75 (02) ◽  
pp. 133-140 ◽  
Author(s):  
Francesco Benedetti ◽  
Roberta Riccaboni ◽  
Clara Locatelli ◽  
Sara Poletti ◽  
Sara Dallaspezia ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Treatment Response ◽  
Bipolar Depression ◽  
Light Therapy ◽  
Drug Resistant ◽  
Rapid Treatment

Phase Advance Is an Actimetric Correlate of Antidepressant Response to Sleep Deprivation and Light Therapy in Bipolar Depression

2007 ◽  
Vol 24 (5) ◽  
pp. 921-937 ◽  
Author(s):  
Francesco Benedetti ◽  
Sara Dallaspezia ◽  
Mara Cigala Fulgosi ◽  
Barbara Barbini ◽  
Cristina Colombo ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Bipolar Depression ◽  
Light Therapy ◽  
Phase Advance ◽  
Antidepressant Response

scholarly journals Effective Antidepressant Chronotherapeutics (Sleep Deprivation and Light Therapy) Normalize the IL-1β:IL-1ra Ratio in Bipolar Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Francesco Benedetti ◽  
Sara Dallaspezia ◽  
Elisa Maria Teresa Melloni ◽  
Cristina Lorenzi ◽  
Raffaella Zanardi ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Bipolar Depression ◽  
Light Therapy ◽  
Low Grade ◽  
Parallel Change ◽  
Lower Baseline ◽  
Before And After ◽  
Severity Of Depression ◽  
Baseline Levels ◽  
Poor Outcomes

BackgroundMood disorders associate with peripheral markers of low-grade inflammation, among which circulating levels of interleukin-1β (IL-1β) consistently predict diagnosis and poor outcomes. Antidepressant chronotherapeutics (total sleep deprivation and light therapy, TSD+LT) prompts response in drug-resistant bipolar depression, but its effect on peripheral inflammation were never assessed. Here we explored the effects of TSD+LT on IL-1β signaling.MethodsWe studied the ratio between IL-1β and its receptor antagonist (IL-1β:IL1ra) in 33 healthy participants, and in 26 inpatients with a major depressive episode in course of Bipolar Disorder, before and after treatment with three cycles of repeated TSD+LT, interspersed with sleep recovery nights, administered during 1 week. Treatment effects of mood and on IL-1β:IL1ra were analyzed in the context of the Generalized Linear Model (GLM).ResultsAt baseline, patients had higher IL-1β, IL1ra, and IL-1β:IL1ra than controls. Treatment significantly decreased IL-1β:IL1ra, by decreasing IL-1β and increasing IL1ra, the effect being proportional to baseline levels and normalizing values. Patients with higher baseline levels showed the highest decrease in IL-1β:IL-1ra, which associated with the immediate antidepressant response at the first cycle; while patients with lower baseline values showed negligible changes in the IL-1β:IL-1ra, unrelated to treatment response.ConclusionWe observed a parallel change of inflammatory biomarkers and severity of depression after chronotherapeutics, suggesting that a reduction in inflammation associated with depression could contribute to the mechanism of action of TSD+LT, and warranting interest for controlled studies addressing the role of inflammation in the recovery from bipolar depression.

Combined sleep deprivation and light therapy: Clinical treatment outcomes in patients with complex unipolar and bipolar depression

2019 ◽  
Vol 246 ◽  
pp. 727-730 ◽  
Author(s):  
D. Sikkens ◽  
R.F. Riemersma - Van der Lek ◽  
Y. Meesters ◽  
R.A. Schoevers ◽  
B.C.M. Haarman
Keyword(s):  
Sleep Deprivation ◽  
Treatment Outcomes ◽  
Bipolar Depression ◽  
Light Therapy ◽  
Clinical Treatment

P.3.12 Recovery from bipolar depression aftertotal sleep deprivation: a 3.0 T BOLD fMRl event-related study of moral thinking

2005 ◽  
Vol 15 ◽  
pp. S61
Author(s):  
A. Bernasconi ◽  
D. Radaelli ◽  
F. Benedetti ◽  
V. Blasi ◽  
M. Cadioli ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Bipolar Depression ◽  
Moral Thinking ◽  
3.0 T
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