Metabolic Syndrome: Major Risk Factor for Morbidity and Mortality in Severely Injured Trauma Patients

2020 ◽  
Vol 230 (1) ◽  
pp. 145-150
Author(s):  
Brett M. Tracy ◽  
Jacob M. Wilson ◽  
Christopher Staley ◽  
Bernadette Frias ◽  
Mara L. Schenker ◽  
...  
2019 ◽  
Vol 229 (4) ◽  
pp. S303
Author(s):  
Brett Tracy ◽  
David Swift ◽  
Bernadette Frias ◽  
Christopher Staley ◽  
Jacob Wilson ◽  
...  

2005 ◽  
Vol 29 (11) ◽  
pp. 1476-1482 ◽  
Author(s):  
Christian A. Kuhne ◽  
Steffen Ruchholtz ◽  
Gernot M. Kaiser ◽  
Dieter Nast-Kolb

2020 ◽  
pp. 000313482095145
Author(s):  
Ram V. Anantha ◽  
Matthew D. Painter ◽  
Franck Diaz-Garelli ◽  
Andrew M. Nunn ◽  
Preston R. Miller ◽  
...  

Background Elderly trauma patients are at risk for undertriage, resulting in substantial morbidity and mortality. The objective of this study was to determine whether implementation of geriatric-specific trauma team activation (TTA) protocols appropriately identified severely-injured elderly patients. Methods This single-center retrospective study evaluated all severely injured (injury severity score [ISS] >15), geriatric (≥65 years) patients admitted to our Level 1 tertiary-care hospital between January 2014 and September 2017. Undertriage was defined as the lack of TTA despite presence of severe injuries. The primary outcome was all-cause in-hospital mortality; secondary outcomes were mortality within 48 hours of admission and urgent hemorrhage control. A multivariable logistic regression analysis was performed to identify predictors of appropriate triage in this study. Results Out of 1039 severely injured geriatric patients, 628 (61%) did not undergo TTA. Undertriaged patients were significantly older and had more comorbidities. In-hospital mortality was 5% and 31% in the undertriaged and appropriately triaged groups, respectively ( P < .0001). One percent of undertriaged patients needed urgent hemorrhage control, compared to 6% of the appropriately triaged group ( P < .0001). One percent of undertriaged patients died within 48 hours compared to 19% in the appropriately triaged group ( P < .0001). Predictors of appropriate triage include GCS, heart rate, systolic blood pressure, lactic acid, ISS, shock, and absence of dementia, stroke, or alcoholism. Discussion Geriatric-specific TTA guidelines continue to undertriage elderly trauma patients when using ISS as a metric to measure undertriage. However, undertriaged patients have much lower morbidity and mortality, suggesting the geriatric-specific TTA guidelines identify those patients at highest risk for poor outcomes.


2008 ◽  
Vol 37 (4) ◽  
pp. 579-584 ◽  
Author(s):  
Luc de Saint Martin ◽  
Elisabeth Pasquier ◽  
Nathalie Roudaut ◽  
Olivier Vandhuick ◽  
Sophie Vallet ◽  
...  

2021 ◽  
Vol 9 (11) ◽  
pp. 2351
Author(s):  
Jannis Kountouras ◽  
Apostolis Papaefthymiou ◽  
Stergios A. Polyzos ◽  
Georgia Deretzi ◽  
Elisabeth Vardaka ◽  
...  

Arterial hypertension is a risk factor for several pathologies, mainly including cardio-cerebrovascular diseases, which rank as leading causes of morbidity and mortality worldwide. Arterial hypertension also constitutes a fundamental component of the metabolic syndrome. Helicobacter pylori infection is one of the most common types of chronic infection globally and displays a plethora of both gastric and extragastric effects. Among other entities, Helicobacter pylori has been implicated in the pathogenesis of the metabolic syndrome. Within this review, we illustrate the current state-of-the-art evidence, which may link several components of the Helicobacter pylori-related metabolic syndrome, including non-alcoholic fatty liver disease and arterial hypertension. In particular, current knowledge of how Helicobacter pylori exerts its virulence through dietary, inflammatory and metabolic pathways will be discussed. Although there is still no causative link between these entities, the emerging evidence from both basic and clinical research supports the proposal that several components of the Helicobacter pylori infection-related metabolic syndrome present an important risk factor in the development of arterial hypertension. The triad of Helicobacter pylori infection, the metabolic syndrome, and hypertension represents a crucial worldwide health problem on a pandemic scale with high morbidity and mortality, like COVID-19, thereby requiring awareness and appropriate management on a global scale.


2017 ◽  
Vol 38 (10) ◽  
pp. 1254-1257 ◽  
Author(s):  
James T. Bernatz ◽  
Nasia Safdar ◽  
Scott Hetzel ◽  
Paul A. Anderson

Clostridium difficile infection (CDI) is associated with increased cost, morbidity, and mortality in postoperative patients. Variable rates of postoperative CDI are reported among 4 surgical specialties during the 30-month study period. Risk factors for CDI include antibiotic use, increased ASA score, and increased admissions in the past year.Infect Control Hosp Epidemiol 2017;38:1254–1257


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